In vivo fluorescence spectroscopy of the human skin: experiments and models.

The results of the experimental investigation of autofluorescence spectra of human skin in vivo caused by the UV radiation of the skin and by the external mechanical pressure applied to the skin are presented. These results are compared with results of Monte Carlo modeling of the autofluorescence of the skin with variable blood content. The proposed simple model of the skin gives the possibility of evaluation of changes of the blood and melanin content within the skin. © 1998 Society of Photo-Optical Instrumentation Engineers.

[1]  Michael H. Gschwend,et al.  Time-gated spectroscopy of intrinsic fluorophores in cells and tissues , 1995, Other Conferences.

[2]  Pascal O. Rol,et al.  Optics for transscleral laser applications , 1991 .

[3]  Steven L. Jacques,et al.  In vivo fluorescence spectroscopy for the diagnosis of skin diseases , 1995, Other Conferences.

[4]  Michael W. Berns,et al.  Influence of tissue parameters on visual reflectance spectra of port wine stains and normal skin , 1996, European Conference on Biomedical Optics.

[5]  Yurii P. Sinichkin,et al.  Investigation of formation and dynamics of human skin erythema and pigmentation by in vivo fluorescence spectroscopy , 1995, Other Conferences.

[6]  Laura Vitellaro‐Zuccarello,et al.  Stereological analysis of collagen and elastic fibers in the normal human dermis: Variability with age, sex, and body region , 1994, The Anatomical record.

[7]  Igor Victorovich Meglinski,et al.  Fluorescence spectroscopy in combination with reflectance measurements in human skin examination: what for and how , 1995, Other Conferences.

[8]  Valery V. Tuchin,et al.  Tissue optics, light distribution, and spectroscopy , 1994 .

[9]  S L Jacques,et al.  In vivo autofluorescence of an unpigmented melanoma in mice. Correlation of spectroscopic properties to microscopic structure , 1995, Melanoma research.

[10]  S. L. Jacques.  The Role of Skin Optics in Diagnostic and Therapeutic Uses of Lasers , 1991 .

[11]  Harri K. Kopola,et al.  Two-channel fiber optic skin erythema meter , 1993 .

[12]  B Chance,et al.  Pyridine Nucleotide as an Indicator of the Oxygen Requirements for Energy‐Linked Functions of Mitochondria , 1976, Circulation research.

[13]  R. Anderson,et al.  In vivo fluorescence of human skin. , 1989, Archives of dermatology.

[14]  S L Jacques,et al.  Fluorescence spectroscopy of turbid media: Autofluorescence of the human aorta. , 1989, Applied optics.

[15]  J. Parrish,et al.  Acute Effects of Ultraviolet Radiation upon the Skin , 1983 .

[16]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[17]  D. J. Ellis,et al.  A theoretical and experimental study of light absorption and scattering by in vivo skin. , 1980, Physics in medicine and biology.

[18]  W Lohmann,et al.  Native fluorescence of the cervix uteri as a marker for dysplasia and invasive carcinoma. , 1989, European journal of obstetrics, gynecology, and reproductive biology.

[19]  J. Fuchs.  Oxidative Injury in Dermatopathology , 1992 .

[20]  Gerhard J. Mueller,et al.  Fiber optical sampling of NADH concentration in guinea pig hearts during ischemia , 1995, Other Conferences.

[21]  Jun Wu,et al.  Fluorescence spectroscopy for colon cancer diagnosis , 1995, Other Conferences.

[22]  Bruce J. Tromberg,et al.  AUTOFLUORESCENCE SPECTROSCOPY OF OPTICALLY TRAPPED CELLS , 1995 .

[23]  J. Parrish,et al.  Topical and Systemic Approaches to Protection of Human Skin against Harmful Effects of Solar Radiation , 1982 .

[24]  Haishan Zeng,et al.  Monte Carlo modeling of tissue autofluorescence measurement and imaging , 1994, Photonics West - Lasers and Applications in Science and Engineering.

[25]  Haishan Zeng,et al.  Spectroscopy and microscopy studies of skin tissue autofluorescence emission , 1995, Other Conferences.

[26]  Haishan Zeng,et al.  Novel microspectrophotometer and its biomedical applications , 1993 .

[27]  Gerhard Sauermann,et al.  Fluorescence-free UV/VIS reflection spectra of human skin , 1993 .