Test‐retest reproducibility of neurochemical profiles with short‐echo, single‐voxel MR spectroscopy at 3T and 7T

To determine the test‐retest reproducibility of neurochemical concentrations obtained with a highly optimized, short‐echo, single‐voxel proton MR spectroscopy (MRS) pulse sequence at 3T and 7T using state‐of‐the‐art hardware.

[1]  Peter B Barker,et al.  Reproducibility of brain spectroscopy at 7T using conventional localization and spectral editing techniques , 2013, Journal of magnetic resonance imaging : JMRI.

[2]  Melissa Terpstra,et al.  Noninvasive quantification of T2 and concentrations of ascorbate and glutathione in the human brain from the same double‐edited spectra , 2011, NMR in biomedicine.

[3]  D. Sharp,et al.  The role of the posterior cingulate cortex in cognition and disease. , 2014, Brain : a journal of neurology.

[4]  R. Menon,et al.  Comparison of the quantification precision of human short echo time 1H spectroscopy at 1.5 and 4.0 Tesla , 2000, Magnetic resonance in medicine.

[5]  R Gruetter,et al.  Field mapping without reference scan using asymmetric echo‐planar techniques , 2000, Magnetic resonance in medicine.

[6]  Gülin Öz,et al.  Short‐echo, single‐shot, full‐intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 T: Validation in the cerebellum and brainstem , 2011, Magnetic resonance in medicine.

[7]  G. Öz.  MR Spectroscopy in Health and Disease , 2021, Handbook of the Cerebellum and Cerebellar Disorders.

[8]  P. Hrdina.  Basic Neurochemistry: Molecular, Cellular and Medical Aspects. , 1996 .

[9]  Peter B Barker,et al.  Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils. , 2015, Magnetic resonance imaging.

[10]  S. Provencher.  Estimation of metabolite concentrations from localized in vivo proton NMR spectra , 1993, Magnetic resonance in medicine.

[11]  D I Hoult.  Rotating frame zeugmatography. , 1980, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[12]  Gülin Öz,et al.  Regional neurochemical profiles in the human brain measured by 1H MRS at 7 T using local B1 shimming , 2012, NMR in biomedicine.

[13]  O Ganslandt,et al.  Short TE single‐voxel 1H‐MR spectroscopy of hippocampal structures in healthy adults at 1.5 Tesla—how reproducible are the results? , 2005, NMR in biomedicine.

[14]  D P Auer,et al.  On the reliability of quantitative clinical magnetic resonance spectroscopy of the human brain , 1995, NMR in biomedicine.

[15]  Oded Gonen,et al.  Human brain‐structure resolved T2 relaxation times of proton metabolites at 3 tesla , 2007, Magnetic resonance in medicine.

[16]  Anthony J. Spychalla,et al.  Early Alzheimer's Disease Neuropathology Detected by Proton MR Spectroscopy , 2014, The Journal of Neuroscience.

[17]  Rolf Gruetter,et al.  Unedited in vivo detection and quantification of γ‐aminobutyric acid in the occipital cortex using short‐TE MRS at 3 T , 2013, NMR in biomedicine.

[18]  Rolf Gruetter,et al.  MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T , 2009, Magnetic resonance in medicine.

[19]  Harald Hampel,et al.  A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe , 2006, European Radiology.

[20]  Steen Moeller,et al.  A geometrically adjustable 16‐channel transmit/receive transmission line array for improved RF efficiency and parallel imaging performance at 7 Tesla , 2008, Magnetic resonance in medicine.

[21]  Frederik Barkhof,et al.  Quantitative 1H‐MRS of healthy human cortex, hippocampus, and thalamus: Metabolite concentrations, quantification precision, and reproducibility , 2004, Journal of magnetic resonance imaging : JMRI.

[22]  Michael Garwood,et al.  Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7 T: T2 relaxation times and concentrations of cerebral metabolites , 2012, NMR in biomedicine.

[23]  Pierre-Gilles Henry,et al.  Improved quantification precision of human brain short echo‐time 1H magnetic resonance spectroscopy at high magnetic field: A simulation study , 2014, Magnetic resonance in medicine.

[24]  Romain Valabregue,et al.  Two‐site reproducibility of cerebellar and brainstem neurochemical profiles with short‐echo, single‐voxel MRS at 3T , 2015, Magnetic resonance in medicine.

[25]  K. Uğurbil,et al.  In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T , 2009, Magnetic resonance in medicine.

[26]  W M Brooks,et al.  Reproducibility of 1H‐MRS in vivo , 1999, Magnetic resonance in medicine.

[27]  S. Debener,et al.  Default-mode brain dysfunction in mental disorders: A systematic review , 2009, Neuroscience & Biobehavioral Reviews.

[28]  Roland Kreis,et al.  The trouble with quality filtering based on relative Cramér‐Rao lower bounds , 2016, Magnetic resonance in medicine.

[29]  Dennis W J Klomp,et al.  Short echo time 1H‐MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses , 2008, Magnetic resonance in medicine.

[30]  P. Renshaw,et al.  T2 relaxation time abnormalities in bipolar disorder and schizophrenia , 2010, Magnetic resonance in medicine.

[31]  Hans Hoogduin,et al.  High‐field MRS of the human brain at short TE and TR , 2011, NMR in biomedicine.

[32]  S. Francis,et al.  Applications of multi-nuclear magnetic resonance spectroscopy at 7T. , 2011, World journal of radiology.

[33]  Peter Kochunov,et al.  Reproducibility of phase rotation STEAM at 3T: Focus on glutathione , 2014, Magnetic resonance in medicine.

[34]  Lynn E Eberly,et al.  Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3 T , 2015, NMR in biomedicine.

[35]  Oded Gonen,et al.  Longitudinal inter‐ and intra‐individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T , 2012, Magnetic resonance in medicine.

[36]  K. Uğurbil,et al.  Measurement of transverse relaxation times of J‐coupled metabolites in the human visual cortex at 4 T , 2012, Magnetic resonance in medicine.

[37]  Peter B Barker,et al.  Comparison of brain gray and white matter macromolecule resonances at 3 and 7 Tesla , 2015, Magnetic resonance in medicine.

[38]  T. Scheenen,et al.  Multi‐center reproducibility of neurochemical profiles in the human brain at 7 T , 2015, NMR in biomedicine.

[39]  V. Govindaraju,et al.  Proton NMR chemical shifts and coupling constants for brain metabolites , 2000, NMR in biomedicine.

[40]  Jens Frahm,et al.  Clinical proton MR spectroscopy in central nervous system disorders. , 2013, Radiology.

[41]  Mauro DiNuzzo,et al.  Neurochemical and BOLD Responses during Neuronal Activation Measured in the Human Visual Cortex at 7 Tesla , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[42]  Rolf Gruetter,et al.  Is the macromolecule signal tissue‐specific in healthy human brain? A 1H MRS study at 7 tesla in the occipital lobe , 2014, Magnetic resonance in medicine.

[43]  Mark G. Vangel,et al.  Confidence Intervals for a Normal Coefficient of Variation , 1996 .

[44]  Uzay E. Emir,et al.  Faster Metabolite 1H Transverse Relaxation in the Elder Human Brain , 2013, PloS one.

[45]  B D Ross,et al.  Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water , 1993 .