The Effect of O-(β-Hydroxyethyl)-Rutosides on Central Haemodynamics During and After Aortocoronary Bypass Surgery

Clinical use of O-(β-hydroxyethyl)-rutosides (HR) has been mainly in chronic venous insufficiency, but to some extent also in arterial insufficiency. We investigated the effect of HR on the central circulation in a group of patients undergoing aortocoronary bypass surgery. Measurements were made during operation and on the first postoperative day, both before and after intravenous injection of 15 ml 10% HR (1.5 g). None of the obtained or calculated values for cardiac output, central blood pressures, coronary blood flow, heart rate, stroke volume and systemic, pulmonary and regional myocardial vascular resistance showed significant change following HR injection intraoperatively or postoperatively. We conclude that this intravenous dosage of HR has no adverse effect on central haemodynamics in patients with advanced coronary disease. This suggests that the drug can also be safely used in patients with peripheral arterial disease, as its beneficial effect cn nutritional skin blood flow in these patients see...

[1]  S. Ekeström,et al.  The Effect of Etilefrine (Effortil®) on Central Hemodynamics and Aorto- Coronary Bypass Blood Flow , 1979, The thoracic and cardiovascular surgeon.

[2]  Erik Svensjö,et al.  Inhibitory effect of the flavonoid O-(beta-hydroxyethyl)-rutoside on increased microvascular permeability induced by various agents in rat skin. , 1983, International journal of microcirculation, clinical and experimental.

[3]  F. Lund.  Fluoreszeinangiographische Studien über die Einwirkung intravenöser Venoruton ® -Behandlung auf die mikrovaskulöre Blutperfusion der Haut bei schweren Fällen von arteriellen Gliedmaßenverschlüssen , 1983 .

[4]  S. Ekeström,et al.  Central haemodynamics and coronary artery blood flow after administration of pentoxifylline to patients with coronary artery disease. A preoperative study , 1982 .

[5]  B. Lindblad,et al.  A double-blind trial of O-(beta-hydroxyethyl)-rutoside in patients with chronic venous insufficiency. , 1981, VASA. Zeitschrift fur Gefasskrankheiten.

[6]  C. Limoni,et al.  [Clinical, placebo-controlled double-blind study of venoruton in the treatment of chronic venous insufficiency. Importance of the selection of patients]. , 1980, VASA. Zeitschrift fur Gefasskrankheiten.

[7]  J. Hladovec,et al.  Suppression of the desquamating effect of smoking on the human endothelium by hydroxyethylrutosides. , 1979, Blood vessels.

[8]  F. Lund.  Fluorescein angiography especially of the upper extremities. , 1976, Acta chirurgica Scandinavica. Supplementum.

[9]  H. Schmid-schönbein,et al.  Effect of o-(beta-hydroxyethyl)-rutosides on the microrheology of human blood under defined flow conditions. , 1975, VASA. Zeitschrift fur Gefasskrankheiten.

[10]  Milliken Jc.  Preliminary observations on the clinical effect of continuous intravenous infusion of HR (O-(beta-hydroxyethyl)-rutosides) in patients with end-point lower limb ischaemia as an adjunct to oral therapy. , 1974 .

[11]  J. T. ten Cate,et al.  Biological activity of a semisynthetic flavonoid, O-( -hydroxyethyl)rutoside: light-scattering and metabolic studies of human red cells and platelets. , 1973, Clinical chemistry.

[12]  G. Arturson.  Effects of O-( -hydroxyethyl)-rutosides (HR) on the increased microvascular permeability in experimental skin burns. Preliminary report. , 1972, Acta chirurgica Scandinavica.

[13]  S. Ekeström,et al.  Blood flow after peripheral arterial reconstruction. I. Measurements after iliac-femoro-popliteal arterial reconstructions with the electromagnetic flowmeter and implanted flow probes during operation and in the early postoperative periods. , 1970, Scandinavian journal of thoracic and cardiovascular surgery.

[14]  S. Ekeström,et al.  Blood flow after peripheral arterial reconstruction. , 1970, Scandinavian journal of thoracic and cardiovascular surgery.