To produce nonionic nanoparticles suited for the encapsulation of hydrophobic drugs, miniemulsion polymerization of vinyl acetate has been carried out with nonionic surfactants and AIBN or hydrogen peroxide−ascorbic acid system as initiator. In addition, oligocaprolactone macromonomers, benzyl benzoate, or triglycerides from fatty acids (Miglyol) have been used as the hydrophobe in order to get biocompatible systems. These oligocaprolactones have been obtained by anionic coordinated ring-opening polymerization in the presence of a transfer agent. Molecular weights have been controlled by using transfer agents. Finally, encapsulation of indomethacin has been performed by adding the drug in the miniemulsion recipe.