Optical detection of single molecules in nanofluidic chips

We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.