Telomere length assessment: biomarker of chronic oxidative stress?

[1]  F. Demetz,et al.  Highly characteristic and individual specific telomere length patterns in cattle. , 2007, Veterinary journal.

[2]  T. Kirkwood,et al.  Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence , 2007, PLoS biology.

[3]  G. Nelson,et al.  TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts , 2007, Mechanisms of Ageing and Development.

[4]  N. Samani,et al.  Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study , 2007, The Lancet.

[5]  Jordan W. Smoller,et al.  Telomere Shortening and Mood Disorders: Preliminary Support for a Chronic Stress Model of Accelerated Aging , 2006, Biological Psychiatry.

[6]  Dan Liu,et al.  A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly , 2006, Proceedings of the National Academy of Sciences.

[7]  Yi-Song Wang,et al.  PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. , 2006, Molecular biology of the cell.

[8]  Yie Liu,et al.  Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and Capping , 2006, Molecular and Cellular Biology.

[9]  J. Campisi,et al.  Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice , 2006, Molecular and Cellular Biology.

[10]  A. Agustí,et al.  Telomere shortening in smokers with and without COPD , 2006, European Respiratory Journal.

[11]  S. Ozanne,et al.  Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity. , 2006, American journal of physiology. Renal physiology.

[12]  T. Zglinicki.  Role of oxidative stress in telomere length regulation and replicative senescence , 2006 .

[13]  S. Rosenberg,et al.  Telomere Length of Transferred Lymphocytes Correlates with In Vivo Persistence and Tumor Regression in Melanoma Patients Receiving Cell Transfer Therapy1 , 2005, The Journal of Immunology.

[14]  G. Roos,et al.  Telomere length and heredity: Indications of paternal inheritance. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[15]  G. Laurent,et al.  Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells. , 2005, Blood.

[16]  Susan Smith,et al.  NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. , 2005, The Biochemical journal.

[17]  Ju Yan,et al.  The telomere length dynamic and methods of its assessment , 2005, Journal of cellular and molecular medicine.

[18]  S. Marcand,et al.  Rap1 prevents telomere fusions by nonhomologous end joining , 2005, The EMBO journal.

[19]  V. Mohan,et al.  Telomere shortening occurs in Asian Indian Type 2 diabetic patients , 2005, Diabetic Medicine.

[20]  A. Aviv,et al.  Obesity, cigarette smoking, and telomere length in women , 2005, The Lancet.

[21]  T. Zglinicki,et al.  Telomeres, cell senescence and human ageing , 2005 .

[22]  J. Shay,et al.  POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end , 2005, The EMBO journal.

[23]  M. Höglund,et al.  Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. , 2005, Carcinogenesis.

[24]  T. Tong,et al.  Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. , 2005, The international journal of biochemistry & cell biology.

[25]  A. Bürkle,et al.  The emerging role of poly(ADP-ribose) polymerase-1 in longevity. , 2005, The international journal of biochemistry & cell biology.

[26]  V. Andrés,et al.  Aging, telomeres, and atherosclerosis. , 2005, Cardiovascular research.

[27]  M. Blasco.  Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging , 2005, The EMBO journal.

[28]  T. von Zglinicki,et al.  Telomeres as biomarkers for ageing and age-related diseases. , 2005, Current molecular medicine.

[29]  K. Yudoh,et al.  Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function , 2005, Arthritis research & therapy.

[30]  R. Holder,et al.  Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: effect of drugs and smoking , 2005, Alimentary pharmacology & therapeutics.

[31]  E. Epel,et al.  Accelerated telomere shortening in response to life stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  S. Baatout,et al.  Telomere biology in mammalian germ cells and during development. , 2004, Developmental biology.

[33]  L. Sabatier,et al.  Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells , 2004, Oncogene.

[34]  N. Gemmell,et al.  Measuring vertebrate telomeres: applications and limitations , 2004, Molecular ecology.

[35]  J. Sastre,et al.  Glutathione Regulates Telomerase Activity in 3T3 Fibroblasts* , 2004, Journal of Biological Chemistry.

[36]  J. Campisi,et al.  Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway , 2004, Molecular and Cellular Biology.

[37]  M. Kastan,et al.  The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response , 2004, PLoS biology.

[38]  D. Broccoli,et al.  Manipulating mouse telomeres: models of tumorigenesis and aging , 2004, Cytogenetic and Genome Research.

[39]  J. Sweasy,et al.  DNA Polymerase β Interacts with TRF2 and Induces Telomere Dysfunction in a Murine Mammary Cell Line , 2004, Cancer Research.

[40]  S. Oikawa,et al.  Mechanism of Telomere Shortening by Oxidative Stress , 2004, Annals of the New York Academy of Sciences.

[41]  K. Myung,et al.  Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86 , 2004, Molecular and Cellular Biology.

[42]  T. Sueda,et al.  Telomere attrition in white blood cell correlating with cardiovascular damage. , 2004, Hypertension research : official journal of the Japanese Society of Hypertension.

[43]  B. Williams,et al.  Rapid telomere attrition in cardiac tissue of the ageing Wistar rat , 2004, Experimental Gerontology.

[44]  A. Akhmedov,et al.  Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells , 2004, Journal of Cell Science.

[45]  F. Ishikawa,et al.  Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. , 2004, Nucleic acids research.

[46]  L. Harrington.  Those dam-aged telomeres! , 2004, Current opinion in genetics & development.

[47]  L. Bégin,et al.  The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1-Related Breast Cancer , 2004, Cancer Research.

[48]  M. Lazar,et al.  Inflamed about obesity , 2004, Nature Medicine.

[49]  M. Blasco,et al.  Short telomeres protect from diet‐induced atherosclerosis in apolipoprotein E‐null mice , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  A. Aviv,et al.  Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects , 2004, Hypertension.

[51]  A. Aljada,et al.  Inflammation: the link between insulin resistance, obesity and diabetes. , 2004, Trends in immunology.

[52]  T. Lange,et al.  DNA Damage Foci at Dysfunctional Telomeres , 2003, Current Biology.

[53]  M. Blasco.  Mammalian telomeres and telomerase: why they matter for cancer and aging. , 2003, European journal of cell biology.

[54]  T. Noakes,et al.  Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeres. , 2003, Medicine and science in sports and exercise.

[55]  Keiji Suzuki,et al.  Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells. , 2003, Free radical biology & medicine.

[56]  G. Nickenig,et al.  Modulation of Antioxidant Enzyme Expression and Function by Estrogen , 2003, Circulation research.

[57]  D. Winkler,et al.  Telomeres shorten more slowly in long-lived birds and mammals than in short–lived ones , 2003, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[58]  G. FitzGerald,et al.  Oxidative stress and smoking-induced vascular injury. , 2003, Progress in cardiovascular diseases.

[59]  N. Samani,et al.  White Cell Telomere Length and Risk of Premature Myocardial Infarction , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[60]  A. Jardine,et al.  Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. , 2003, The American journal of pathology.

[61]  M. Atmaca,et al.  Free radicals in patients with post-traumatic stress disorder , 2003, European Archives of Psychiatry and Clinical Neuroscience.

[62]  S. Ozanne,et al.  Ageing and telomeres: a study into organ- and gender-specific telomere shortening. , 2003, Nucleic acids research.

[63]  R. Cawthon,et al.  Association between telomere length in blood and mortality in people aged 60 years or older , 2003, The Lancet.

[64]  P. Lansdorp,et al.  Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. , 2003, Human molecular genetics.

[65]  C. Szabó,et al.  The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors , 2002, Pharmacological Reviews.

[66]  T. Zglinicki.  Oxidative stress shortens telomeres , 2002 .

[67]  H. Canatan,et al.  Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder , 2002, Cell biochemistry and function.

[68]  R. Cawthon.  Telomere measurement by quantitative PCR. , 2002, Nucleic acids research.

[69]  W. MacNee,et al.  Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. , 2002, Molecular and cellular biochemistry.

[70]  I. Komuro,et al.  Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction , 2002, Circulation.

[71]  A. Aljada,et al.  Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. , 2002, The Journal of clinical endocrinology and metabolism.

[72]  J. Shay,et al.  Telomerase regulation: not just flipping the switch. , 2002, Current opinion in genetics & development.

[73]  K. Collins,et al.  Telomerase in the human organism , 2002, Oncogene.

[74]  Brandoch D. Cook,et al.  Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres , 2002, Molecular and Cellular Biology.

[75]  Xiao Zhen Zhou,et al.  Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA Breaks* , 2001, The Journal of Biological Chemistry.

[76]  T. Zglinicki.  Telomeres and replicative senescence: Is it only length that counts? , 2001 .

[77]  A. Aljada,et al.  Insulin Inhibits Intranuclear Nuclear Factor κB and Stimulates IκB in Mononuclear Cells in Obese Subjects: Evidence for an Anti-inflammatory Effect? , 2001 .

[78]  Thomas B. L. Kirkwood,et al.  Stress, DNA damage and ageing — an integrative approach , 2001, Experimental Gerontology.

[79]  S. Oikawa,et al.  Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening. , 2001, Biochemistry.

[80]  A. Barzilai,et al.  Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. , 2001, Cancer research.

[81]  S. Smith,et al.  The world according to PARP. , 2001, Trends in biochemical sciences.

[82]  P. Hamet,et al.  Is Hypertension a Case of Accelerated Aging of Cardiovascular Cells? , 2001, Hypertension.

[83]  J. Skurnick,et al.  Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity , 2001, Hypertension.

[84]  D. Argyle,et al.  Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology. , 2001, Neoplasia.

[85]  U. Klotz,et al.  Telomere length in different tissues of elderly patients , 2000, Mechanisms of Ageing and Development.

[86]  B. J. Jennings,et al.  Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging? , 2000, Molecular genetics and metabolism.

[87]  J. Skurnick,et al.  Telomere length inversely correlates with pulse pressure and is highly familial. , 2000, Hypertension.

[88]  G. Saretzki,et al.  Telomere Length As a Marker of Oxidative Stress in Primary Human Fibroblast Cultures , 2000, Annals of the New York Academy of Sciences.

[89]  T. Finkel,et al.  Homocysteine accelerates endothelial cell senescence , 2000, FEBS letters.

[90]  T. Zglinicki,et al.  Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. , 2000, Free radical biology & medicine.

[91]  Carl Foster,et al.  Overload, Performance Incompetence, and Regeneration in Sport , 1999, Springer US.

[92]  K. Hensley,et al.  Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps. , 1999, Life sciences.

[93]  M. Prakash Hande,et al.  Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability , 1999, Nature Genetics.

[94]  S. Oikawa,et al.  Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening , 1999, FEBS letters.

[95]  J. Ménissier-de murcia,et al.  Poly(ADP-ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease. , 1999, American journal of human genetics.

[96]  B. J. Jennings,et al.  Early growth determines longevity in male rats and may be related to telomere shortening in the kidney , 1999, FEBS letters.

[97]  D. Broccoli,et al.  p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. , 1999, Science.

[98]  T. Noakes,et al.  Regeneration After Ultra-Endurance Exercise , 1999 .

[99]  R. Venkatesan,et al.  Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[100]  T. Lange,et al.  Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. , 1998, Science.

[101]  E. Hiyama,et al.  Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. , 1998, Life sciences.

[102]  T. Toyota,et al.  Telomere shortening in the colonic mucosa of patients with ulcerative colitis , 1998, Journal of Gastroenterology.

[103]  M. Masson,et al.  XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage , 1998, Molecular and Cellular Biology.

[104]  G. Saretzki,et al.  Accelerated telomere shortening in fibroblasts after extended periods of confluency. , 1998, Free radical biology & medicine.

[105]  J. Skurnick,et al.  Shortened telomere length in white blood cells of patients with IDDM. , 1998, Diabetes.

[106]  S. Petersen,et al.  Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. , 1998, Experimental cell research.

[107]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[108]  J. Langmore,et al.  Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening , 1997, Cell.

[109]  S. Ozanne,et al.  Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. , 1996, Biochemical Society transactions.

[110]  E. Blackburn,et al.  Telomeres, telomerase and cancer. , 1996, Scientific American.

[111]  C. Harley,et al.  Telomere length and replicative aging in human vascular tissues. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[112]  G. Saretzki,et al.  Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? , 1995, Experimental cell research.

[113]  D I Boomsma,et al.  Genetic determination of telomere size in humans: a twin study of three age groups. , 1994, American journal of human genetics.

[114]  C B Harley,et al.  Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[115]  E. Blackburn,et al.  Structure and function of telomeres , 1991, Nature.

[116]  D. Kipling,et al.  Hypervariable ultra-long telomeres in mice , 1990, Nature.

[117]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[118]  R. Moyzis,et al.  Conservation of the human telomere sequence (TTAGGG)n among vertebrates. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[119]  L. S. Cram,et al.  A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[120]  L. Hayflick.  THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. , 1965, Experimental cell research.