论文信息 - Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse

Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse

Rats allowed concurrent access to intravenous heroin and intracranial self-stimulation (ICSS) showed facilitation of ICSS while maintaining stable self-administration of heroin. The facilitatory action of heroin on ICSS was indexed by an increase in response rates and a lowering of intensity thresholds. Both measures showed dose-dependent changes, but only threshold tracking allowed a reliable determination of the time-dependent effect of self-administered heroin on ICSS.

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