Ral activation promotes melanomagenesis

[1]  C. Der,et al.  Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA , 2009, Molecular and Cellular Biology.

[2]  J. Garlick,et al.  RalA Suppresses Early Stages of Ras-Induced Squamous Cell Carcinoma Progression , 2009, Oncogene.

[3]  A. Kurtz,et al.  Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors , 2009, Molecular and Cellular Biology.

[4]  M. Kersten,et al.  Annemieke multiple myeloma cells induced migration of B cells and − The small GTPase Ral mediates , 2008 .

[5]  M. White,et al.  Ral GTPases and cancer: linchpin support of the tumorigenic platform , 2008, Nature Reviews Cancer.

[6]  C. Der,et al.  Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth , 2007, Molecular and Cellular Biology.

[7]  K. Kelly,et al.  Activation of the RalGEF/Ral Pathway Promotes Prostate Cancer Metastasis to Bone , 2007, Molecular and Cellular Biology.

[8]  D. Theodorescu,et al.  Expression of Ral GTPases, Their Effectors, and Activators in Human Bladder Cancer , 2007, Clinical Cancer Research.

[9]  W. Hahn,et al.  The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase , 2007, Cell.

[10]  R. Marais,et al.  Melanoma biology and new targeted therapy , 2007, Nature.

[11]  S. Adam,et al.  Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells , 2006, Current Biology.

[12]  M. White,et al.  RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival , 2006, Cell.

[13]  M. White,et al.  RalB Mobilizes the Exocyst To Drive Cell Migration , 2006, Molecular and Cellular Biology.

[14]  D. Theodorescu,et al.  RalA and RalB: antagonistic relatives in cancer cell migration. , 2005, Cancer research.

[15]  M. Shipitsin,et al.  Activation of RalA is critical for Ras-induced tumorigenesis of human cells. , 2005, Cancer cell.

[16]  Chi-Ying F. Huang,et al.  Identification of V23RalA-Ser194 as a Critical Mediator for Aurora-A-induced Cellular Motility and Transformation by Small Pool Expression Screening* , 2005, Journal of Biological Chemistry.

[17]  G. Stamp,et al.  RalGDS is required for tumor formation in a model of skin carcinogenesis. , 2005, Cancer cell.

[18]  M. White,et al.  RAL GTPases are linchpin modulators of human tumour‐cell proliferation and survival , 2003, EMBO reports.

[19]  L. Feig.  Ral-GTPases: approaching their 15 minutes of fame. , 2003, Trends in cell biology.

[20]  C. Der,et al.  Distinct requirements for Ras oncogenesis in human versus mouse cells. , 2002, Genes & development.

[21]  M. White,et al.  Differential Effects of Protein Kinase A on Ras Effector Pathways , 1998, Molecular and Cellular Biology.

[22]  R. Wolthuis,et al.  Activation of the Small GTPase Ral in Platelets , 1998, Molecular and Cellular Biology.

[23]  A. Pellicer,et al.  rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral , 1997, Oncogene.

[24]  M. Wigler,et al.  A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation* , 1996, The Journal of Biological Chemistry.

[25]  M. Wigler,et al.  Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation , 1996, Molecular and cellular biology.

[26]  T. Urano,et al.  Ral‐GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. , 1996, The EMBO journal.

[27]  G. Merlino,et al.  Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation , 2011, Oncogene.

[28]  W. Hahn,et al.  The tumor suppressor PP2A Abeta regulates the RalA GTPase. , 2007, Cell.

[29]  J. Downward.  Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.