The adrenal and polycystic ovary syndrome

[1]  M. Goodarzi,et al.  Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. , 2007, The Journal of clinical endocrinology and metabolism.

[2]  M. Goodarzi,et al.  Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters. , 2007, American journal of obstetrics and gynecology.

[3]  J. Rotter,et al.  Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters. , 2006, Fertility and sterility.

[4]  R. Norman,et al.  Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. , 2006, The Journal of clinical endocrinology and metabolism.

[5]  I. Lavi,et al.  Hyperandrogenism in carriers of CYP21 mutations: the role of genotype , 2006, Clinical endocrinology.

[6]  V. Castracane,et al.  Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome. , 2006, Fertility and sterility.

[7]  R. Azziz,et al.  Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. , 2005, The Journal of clinical endocrinology and metabolism.

[8]  R. Azziz,et al.  Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS) , 2005, Clinical endocrinology.

[9]  R. Azziz,et al.  Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess. , 2005, Fertility and sterility.

[10]  R. Azziz,et al.  Stability of adrenocortical steroidogenesis over time in healthy women and women with polycystic ovary syndrome. , 2004, The Journal of clinical endocrinology and metabolism.

[11]  R. Azziz,et al.  Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. , 2004, Fertility and sterility.

[12]  Ricardo Azziz,et al.  0021-972X/04/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 89(6):2745–2749 Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/jc.2003-032046 The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected , 2022 .

[13]  A. Lanzone,et al.  Effect of pioglitazone treatment on the adrenal androgen response to corticotrophin in obese patients with polycystic ovary syndrome. , 2004, Human reproduction.

[14]  P. Claman Men at risk: occupation and male infertility. , 2004, Fertility and sterility.

[15]  B. Scoccia,et al.  The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency. , 2004, The Journal of clinical endocrinology and metabolism.

[16]  T. Tsilchorozidou,et al.  Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates. , 2003, The Journal of clinical endocrinology and metabolism.

[17]  R. Azziz,et al.  Prevalence of insulin resistance in Polycystic Ovary Syndrome (PCOS) patients using the Homeostatic Measurement Assessment (HOMA-IR) , 2003 .

[18]  R. Azziz,et al.  Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS) using age-specific DHEAS levels adjusted for body mass and ethnicity , 2003 .

[19]  M. Fassnacht,et al.  Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome. , 2003, The Journal of clinical endocrinology and metabolism.

[20]  D. Ehrmann,et al.  Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome. , 2003, Fertility and sterility.

[21]  P. Czernichow,et al.  Endocrine consequences of premature pubarche in post‐pubertal Caucasian girls , 2002, Clinical endocrinology.

[22]  B. Rich,et al.  Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency. , 2002, The Journal of clinical endocrinology and metabolism.

[23]  A. Kunselman,et al.  Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome. , 2002, The Journal of clinical endocrinology and metabolism.

[24]  R. Saad,et al.  Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. , 2002, The Journal of clinical endocrinology and metabolism.

[25]  R. Azziz,et al.  Influence of insulin and testosterone on adrenocortical steroidogenesis in vitro: preliminary studies. , 2001, Fertility and sterility.

[26]  R. Azziz,et al.  Adrenocortical secretion of dehydroepiandrosterone in healthy women: highly variable response to adrenocorticotropin. , 2001, The Journal of clinical endocrinology and metabolism.

[27]  W. Miller,et al.  Thiazolidinediones but Not Metformin Directly Inhibit the Steroidogenic Enzymes P450c17 and 3β-Hydroxysteroid Dehydrogenase* , 2001, The Journal of Biological Chemistry.

[28]  V. Rohmer,et al.  21-Hydroxylase-deficient nonclassic adrenal hyperplasia is a progressive disorder: a multicenter study. , 2000, American journal of obstetrics and gynecology.

[29]  E. Feingold,et al.  A variant of the glucocorticoid receptor gene is not associated with adrenal androgen excess in women with polycystic ovary syndrome. , 2000, Fertility and sterility.

[30]  R. Pasquali,et al.  Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. , 2000, The Journal of clinical endocrinology and metabolism.

[31]  M. Vogeser,et al.  Corticosteroid-binding globulin and unbound serum cortisol in women with polycystic ovary syndrome. , 2000, Clinical biochemistry.

[32]  R. Azziz,et al.  11beta-hydroxyandrostenedione and delta5-androstenediol as markers of adrenal androgen production in patients with 21-hydroxylase-deficient nonclassic adrenal hyperplasia. , 1999, Fertility and sterility.

[33]  G. Morgante,et al.  Effects of metformin on adrenal steroidogenesis in women with polycystic ovary syndrome. , 1999, Fertility and sterility.

[34]  J. Preželj,et al.  Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status. , 1999, European journal of endocrinology.

[35]  R. Azziz,et al.  Adrenal androgen excess in hyperandrogenism: relation to age and body mass. , 1999, Fertility and sterility.

[36]  A. Boulton,et al.  Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity. , 1999, The Journal of clinical endocrinology and metabolism.

[37]  R. Azziz,et al.  Impact of architectural disruption on adrenocortical steroidogenesis in vitro. , 1999, The Journal of clinical endocrinology and metabolism.

[38]  R. Azziz,et al.  Adrenal androgen excess in the polycystic ovary syndrome: sensitivity and responsivity of the hypothalamic-pituitary-adrenal axis. , 1998, The Journal of clinical endocrinology and metabolism.

[39]  R. Azziz,et al.  Role of the ovary in the adrenal androgen excess of hyperandrogenic women. , 1998, Fertility and Sterility.

[40]  W. Scherbaum,et al.  Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. , 1998, Endocrine reviews.

[41]  S. Bowlin,et al.  Longitudinal changes in dehydroepiandrosterone concentrations in men and women. , 1998, The Journal of laboratory and clinical medicine.

[42]  R. Pasquali,et al.  Secretion of Major Adrenal Androgens Following ACTH Administration in Obese Women with Different Body Fat Distribution , 1998, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[43]  J. Honour,et al.  Carrier status for steroid 21‐hydroxylase deficiency is only one factor in the variable phenotype of acne , 1998, Clinical endocrinology.

[44]  R. Azziz,et al.  The Effect of 17β-Estradiol on Adrenocortical Sensitivity, Responsiveness, and Steroidogenesis in Postmenopausal Women1 , 1998 .

[45]  P. A. Lee,et al.  Hyperandrogenism and manifesting heterozygotes for 21-hydroxylase deficiency. , 1997, Biochemical and molecular medicine.

[46]  A. Dunaif,et al.  Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. , 1997, Endocrine reviews.

[47]  R. Kofler,et al.  CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency. , 1997, Human molecular genetics.

[48]  L. Ibáñez,et al.  Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: evidence from gonadotropin-releasing hormone agonist testing. , 1997, Fertility and sterility.

[49]  R. Azziz,et al.  Molecular abnormalities of the 21-hydroxylase gene in hyperandrogenic women with an exaggerated 17-hydroxyprogesterone response to short-term adrenal stimulation. , 1995, American journal of obstetrics and gynecology.

[50]  E. Baulieu,et al.  Serum dehydroepiandrosterone sulfate levels as an individual marker. , 1994, The Journal of clinical endocrinology and metabolism.

[51]  C. V. D. van de Velde,et al.  Identification of virilizing adrenal tumors in hirsute women. , 1994, The New England journal of medicine.

[52]  R. Lobo,et al.  Ovarian suppression reduces clinical and endocrine expression of late-onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency. , 1994, Fertility and sterility.

[53]  Stewart Pm,et al.  Hyperandrogenism in polycystic ovary syndrome. , 1994, The New England journal of medicine.

[54]  R. Azziz,et al.  Clinical review 56: Nonclassic adrenal hyperplasia: current concepts. , 1994, The Journal of clinical endocrinology and metabolism.

[55]  R. Clayton,et al.  Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase. , 1994, The New England journal of medicine.

[56]  S. Bulun,et al.  Competitive reverse transcription-polymerase chain reaction analysis indicates that levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. , 1994, The Journal of clinical endocrinology and metabolism.

[57]  I. Borecki,et al.  The Cincinnati Myocardial Infarction and Hormone Family Study: family resemblance for dehydroepiandrosterone sulfate in control and myocardial infarction families. , 1993, Metabolism: clinical and experimental.

[58]  L. Balint-perić,et al.  24-hour serum cortisol profiles in women with polycystic ovary syndrome. , 1993, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[59]  L. Ibáñez,et al.  Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. , 1993, The Journal of clinical endocrinology and metabolism.

[60]  R. Rittmaster,et al.  The role of adrenal hyperandrogenism, insulin resistance, and obesity in the pathogenesis of polycystic ovarian syndrome. , 1993, The Journal of clinical endocrinology and metabolism.

[61]  D. London,et al.  The hypothalamo‐pituitary‐adrenal axis across the normal menstrual cycle and in polycystic ovary syndrome , 1993, Clinical endocrinology.

[62]  R. Lobo,et al.  Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? , 1992, American journal of obstetrics and gynecology.

[63]  R. Legro,et al.  Chediak‐Higashi syndrome in pregnancy , 1992, Obstetrics and gynecology.

[64]  D. de Ziegler,et al.  Long-term administration of gonadotropin-releasing hormone agonist and dexamethasone: assessment of the adrenal role in ovarian dysfunction. , 1992, Fertility and sterility.

[65]  R. Azziz,et al.  Abnormalities of 21-hydroxylase gene ratio and adrenal steroidogenesis in hyperandrogenic women with an exaggerated 17-hydroxyprogesterone response to acute adrenal stimulation. , 1991, The Journal of clinical endocrinology and metabolism.

[66]  R. Lobo,et al.  Is the inappropriate gonadotropin secretion of patients with polycystic ovary syndrome similar to that of patients with adult-onset congenital adrenal hyperplasia? , 1991, Fertility and sterility.

[67]  L. Speroff,et al.  Adrenal and ovarian steroid hormone responses to gonadotropin-releasing hormone agonist treatment in polycystic ovary syndrome. , 1991, American journal of obstetrics and gynecology.

[68]  R. Azziz,et al.  Effect of obesity on the response to acute adrenocorticotropin stimulation in eumenorrheic women. , 1991, Fertility and sterility.

[69]  R. Azziz,et al.  Adrenal Androgens and Reproductive Aging in Females , 1991 .

[70]  C. Invitti,et al.  Increased urinary free cortisol and decreased serum corticosteroid-binding globulin in polycystic ovary syndrome. , 1991, Acta endocrinologica.

[71]  R. Azziz,et al.  The effects of prolonged hypertestosteronemia on adrenocortical biosynthesis in oophorectomized women. , 1991, The Journal of clinical endocrinology and metabolism.

[72]  I. G. Fantus,et al.  Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women. , 1990, The Journal of clinical endocrinology and metabolism.

[73]  R. Lobo,et al.  Pituitary-adrenal responses to ovine corticotropin-releasing factor in polycystic ovary syndrome and in other hyperandrogenic patients. , 1990, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[74]  R. Lobo,et al.  Ovine corticotropin-releasing factor and dexamethasone responses in hyperandrogenic women. , 1990, Fertility and sterility.

[75]  D. Thompson,et al.  Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. , 1990, The Journal of clinical endocrinology and metabolism.

[76]  C. Edwards,et al.  5 α-reductase activity in polycystic ovary syndrome , 1990, The Lancet.

[77]  D. Bishop,et al.  Heritability of variation of plasma cortisol levels. , 1988, Metabolism: clinical and experimental.

[78]  K. Carlström,et al.  Adrenal steroids in post-menopausal women: relation to obesity and to bone mineral content. , 1987, Maturitas.

[79]  S. Komindr,et al.  Relative sensitivity and responsivity of serum cortisol and two adrenal androgens to alpha-adrenocorticotropin-(1-24) in normal and obese, nonhirsute, eumenorrheic women. , 1986, The Journal of clinical endocrinology and metabolism.

[80]  P. Fossati,et al.  Clinical and biological phenotypes in late-onset 21-hydroxylase deficiency. , 1986, The Journal of clinical endocrinology and metabolism.

[81]  R. Barbieri,et al.  Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. , 1986, The Journal of clinical endocrinology and metabolism.

[82]  E. Carmina,et al.  Increased DHEAs levels in PCO syndrome: evidence for the existence of two subgroups of patients , 1986, Journal of endocrinological investigation.

[83]  J. Rotter,et al.  A genetic component to the variation of dehydroepiandrosterone sulfate. , 1985, Metabolism: clinical and experimental.

[84]  K. D. Smith,et al.  Testosterone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate in hyperandrogenic women. , 1984, The Journal of clinical endocrinology and metabolism.

[85]  R. Lobo,et al.  The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. , 1984, Fertility and sterility.

[86]  D. London,et al.  ACTH FUNCTION IN WOMEN WITH THE POLYCYSTIC OVARIAN SYNDROME , 1983, Clinical endocrinology.

[87]  R. Horton,et al.  Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome. , 1983, The Journal of clinical endocrinology and metabolism.

[88]  R. Wild,et al.  Androgen parameters and their correlation with body weight in one hundred thirty-eight women thought to have hyperandrogenism. , 1983, American journal of obstetrics and gynecology.

[89]  C. Mendelson,et al.  Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. , 1981, The Journal of clinical endocrinology and metabolism.

[90]  B. Schwarz,et al.  Aromatization of androstenedione to estrone by human adipose tissue in vitro. Correlation with adipose tissue mass, age, and endometrial neoplasia. , 1981, The Journal of clinical endocrinology and metabolism.

[91]  R. Lobo,et al.  Dehydroepiandrosterone Sulfate as an Indicator of Adrenal Androgen Function , 1981, Obstetrics and gynecology.

[92]  K. Kato,et al.  Studies on changes in the concentration of serum adrenal androgens in pubertal twins. , 1980, Acta endocrinologica.

[93]  M. New,et al.  Dehydroepiandrosterone sulfate (DS) levels, a rapid test for abnormal adrenal androgen secretion. , 1976, The Journal of clinical endocrinology and metabolism.

[94]  A. Kappas,et al.  Adrenocortical hyperfunction in idiopathic hirsutism and the Stein-Leventhal syndrome. , 1958, The Journal of clinical investigation.

[95]  M. Goodarzi,et al.  Genes for Enzymes Regulating DHEA Sulfonation are Associated with Levels of DHEA-Sulfate in Polycystic Ovary Syndrome 1 , 2007 .

[96]  R. Azziz,et al.  Hypothalamic-Pituitary-Adrenal Dysfunction in the Polycystic Ovary Syndrome , 2006 .

[97]  R. Azziz,et al.  Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome. , 2004, Fertility and sterility.

[98]  Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. , 2004, Fertility and sterility.

[99]  R. Azziz,et al.  Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess. , 2004, Fertility and sterility.

[100]  B. Fauser,et al.  Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). , 2004, Human reproduction.

[101]  C. Aston,et al.  The role of heterozygosity for CYP21 in the polycystic ovary syndrome. , 2000, Journal of pediatric endocrinology & metabolism : JPEM.

[102]  B. Walker,et al.  Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome. , 2000, Clinical Endocrinology.

[103]  W. Dodson,et al.  Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. , 1999, The Journal of clinical endocrinology and metabolism.

[104]  M. Matzuk,et al.  Overexpression of mouse follistatin causes reproductive defects in transgenic mice. , 1998, Molecular endocrinology.

[105]  R. Azziz,et al.  The effect of 17 beta-estradiol on adrenocortical sensitivity, responsiveness, and steroidogenesis in postmenopausal women. , 1998, The Journal of clinical endocrinology and metabolism.

[106]  I. Kohane,et al.  Follow-up study of adolescent girls with a history of premature pubarche. , 1996, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[107]  C. Edwards,et al.  5 alpha-reductase activity in polycystic ovary syndrome. , 1990, Lancet.

[108]  G. Okoev,et al.  [Diagnostic criteria for polycystic ovary syndrome]. , 1989, Akusherstvo i ginekologiia.

[109]  J. Clore,et al.  The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. , 1987, The Journal of clinical endocrinology and metabolism.