Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.

[1]  G. Kristiansen,et al.  Systematic Expression Analysis of Mitochondrial Complex I Identifies NDUFS1 as a Biomarker in Clear‐Cell Renal‐Cell Carcinoma , 2017, Clinical genitourinary cancer.

[2]  C. Burant,et al.  Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis. , 2017, Cancer research.

[3]  Siwen Hu,et al.  Caudatin targets TNFAIP1/NF-κB and cytochrome c/caspase signaling to suppress tumor progression in human uterine cancer. , 2016, International journal of oncology.

[4]  M. Hsiao,et al.  The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I , 2016, Scientific Reports.

[5]  Christian M. Metallo,et al.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth , 2016, Nature.

[6]  K. Somasundaram,et al.  Epigenetically silenced GNG4 inhibits SDF1α/CXCR4 signaling in mesenchymal glioblastoma , 2016, Genes & cancer.

[7]  J. Kelleher,et al.  Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake , 2015, Science Signaling.

[8]  Nicholas D. Adams,et al.  New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. , 2015, Nature chemical biology.

[9]  Yun Yu,et al.  Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. , 2015, Biochemical and biophysical research communications.

[10]  C. Croce,et al.  MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer , 2015, Proceedings of the National Academy of Sciences.

[11]  Zhiyong Guo,et al.  Interaction between microRNA-181a and TNFAIP1 regulates pancreatic cancer proliferation and migration , 2015, Tumor Biology.

[12]  Steven J. M. Jones,et al.  Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. , 2015, The New England journal of medicine.

[13]  S. Inoue,et al.  Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio , 2015, Cell Death and Differentiation.

[14]  T. Cloughesy,et al.  Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma , 2015, Nature Reviews Cancer.

[15]  L. Chin,et al.  miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma , 2015, Genes & development.

[16]  F. Holstege,et al.  FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression , 2015, EMBO reports.

[17]  Yide Mei,et al.  MiR-181a regulates lipid metabolism via IDH1 , 2015, Scientific Reports.

[18]  S. Galavotti,et al.  Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells , 2015, Proceedings of the National Academy of Sciences.

[19]  R. Deberardinis,et al.  Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases , 2014, Cell.

[20]  M. Hedehus,et al.  Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma , 2014, Proceedings of the National Academy of Sciences.

[21]  S. Zupo,et al.  NAC, Tiron and Trolox Impair Survival of Cell Cultures Containing Glioblastoma Tumorigenic Initiating Cells by Inhibition of Cell Cycle Progression , 2014, PloS one.

[22]  T. Cloughesy,et al.  Glioblastoma: from molecular pathology to targeted treatment. , 2014, Annual review of pathology.

[23]  K. Vousden,et al.  Metabolic Regulation by p53 Family Members , 2013, Cell metabolism.

[24]  D. Haussler,et al.  The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.

[25]  Jan J. Brosens,et al.  Forkhead box proteins: tuning forks for transcriptional harmony. , 2013, Nature reviews. Cancer.

[26]  J. Hirst.  Mitochondrial complex I. , 2013, Annual review of biochemistry.

[27]  W. Kaelin,et al.  What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. , 2013, Genes & development.

[28]  C. Horbinski.  What do we know about IDH1/2 mutations so far, and how do we use it? , 2013, Acta Neuropathologica.

[29]  Xiaofeng Li,et al.  microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells. , 2013, International journal of oncology.

[30]  Jinfeng Liu,et al.  FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. , 2012, Cancer research.

[31]  Jeen-Woo Park,et al.  RNA interference targeting cytosolic NADP(+)-dependent isocitrate dehydrogenase exerts anti-obesity effect in vitro and in vivo. , 2012, Biochimica et biophysica acta.

[32]  R. Deberardinis,et al.  Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. , 2012, Cell metabolism.

[33]  Gerald C. Chu,et al.  Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.

[34]  Zhaoshi Jiang,et al.  Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[35]  Jesse M. Platt,et al.  Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability , 2011, Proceedings of the National Academy of Sciences.

[36]  Christian M. Metallo,et al.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.

[37]  M. V. Vander Heiden,et al.  Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.

[38]  M. Prados,et al.  An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. , 2011, Cancer discovery.

[39]  C. Hoogenraad,et al.  IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo , 2011, Annals of neurology.

[40]  Hai Yan,et al.  Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. , 2010, Journal of the National Cancer Institute.

[41]  R. Rodenburg,et al.  Novel mutations in the NDUFS1 gene cause low residual activities in human complex I deficiencies. , 2010, Molecular genetics and metabolism.

[42]  W. Vandertop,et al.  The prognostic IDH1R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma , 2010, Acta Neuropathologica.

[43]  S. Horvath,et al.  EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy , 2009, Science Signaling.

[44]  G. Smyth,et al.  ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. , 2009, Journal of immunological methods.

[45]  Paul S Mischel,et al.  The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis , 2009, Proceedings of the National Academy of Sciences.

[46]  Gerald C. Chu,et al.  P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation , 2008, Nature.

[47]  Ralph J Deberardinis,et al.  Brick by brick: metabolism and tumor cell growth. , 2008, Current opinion in genetics & development.

[48]  R. Deberardinis,et al.  Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.

[49]  J. Menéndez,et al.  Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis , 2007, Nature Reviews Cancer.

[50]  V. Appanna,et al.  The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist , 2007, PloS one.

[51]  Jeen-Woo Park,et al.  Regulation of singlet oxygen-induced apoptosis by cytosolic NADP+-dependent isocitrate dehydrogenase , 2007, Molecular and Cellular Biochemistry.

[52]  R. Raval,et al.  Identification of novel VHL target genes and relationship to hypoxic response pathways , 2005, Oncogene.

[53]  P. Kleihues,et al.  Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. , 2005, Journal of neuropathology and experimental neurology.

[54]  T. Huh,et al.  Cytosolic NADP+-dependent Isocitrate Dehydrogenase Plays a Key Role in Lipid Metabolism* , 2004, Journal of Biological Chemistry.

[55]  Robert P. Hausinger,et al.  Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes , 2004 .

[56]  I. Shechter,et al.  IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells. , 2003, Journal of lipid research.

[57]  L. Boros,et al.  Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts. , 2002, Molecular genetics and metabolism.

[58]  T. Huh,et al.  Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. , 2002, Free radical biology & medicine.

[59]  T. Huh,et al.  Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase. , 2002, Biochemical and biophysical research communications.

[60]  N. Copeland,et al.  Structure and Chromosomal Localization of Mouse G Protein Subunit γ4 Gene , 1998 .

[61]  T. Shows,et al.  Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. , 1992, The Journal of biological chemistry.

[62]  K. Dalziel,et al.  Isocitrate dehydrogenase and related oxidative decarboxylases , 1980, FEBS letters.

[63]  Christian M. Metallo,et al.  Metabolic pathway alterations that support cell proliferation. , 2011, Cold Spring Harbor symposia on quantitative biology.

[64]  Amy E. Hawkins,et al.  Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2009 .

[65]  J. Uhm.  An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2009 .

[66]  R. Hausinger.  FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. , 2004, Critical reviews in biochemistry and molecular biology.

[67]  N. Copeland,et al.  Structure and chromosomal localization of mouse G protein subunit gamma 4 gene. , 1998, Genomics.

[68]  M. Cascante,et al.  Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism? , 1998, Medical hypotheses.