Modelos experimentais para o estudo do vasoespasmo cerebral: Revisão da literatura

Resumo O vasoespasmo cerebral é a principal complicação da hemorragia subaracnóidea, não existindo, até o momento, um trat amento específico para ele, provavelmente em razão do desconhecimento de todos os seus mecanismos fisiopatológicos. Diante da necessidade de se conhecer melhor o vasoespasmo cerebral, vários modelos experimentais foram desenvolvidos, em diversas espécies de animais. No presente artigo é apresentada revisão sobre os modelos experimentais de vasoespasmo cerebral, com base na pequisa no Medline Medical Database, abrangendo o período de 1960 a 2002, utilizando-se as palavras-chave “animal”, “model”, “experimental”, “vasospasm” e “hemorrhage”. Os modelos foram classificados em três categorias, de acordo com a técnica utilizada para promover a hemorragia subaracnóidea, sendo analisadas as vantagens e desvantagens de cada categoria.

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