DNA repair in humans.

DNA repair is an important molecular defense system against agents that cause cancer, degenerative diseases, and aging. Several repair systems in humans protect the genome by repairing modified bases, DNA adducts, crosslinks, and double strand breaks. These repair systems, base excision, nucleotide excision, and recombination, are intimately connected to transcription and to cell cycle checkpoints. In addition, genotoxic stress induces a set of cellular reactions mediated by the p53 tumor suppressor and the Ras oncogene. These genotoxic response reactions may help the cell survive or enter apoptosis. Damage-response reactions may be utilized as targets of anticancer chemotherapy.

[1]  L. Pearl,et al.  The structural basis of specific base-excision repair by uracil–DNA glycosylase , 1996, Nature.

[2]  D. Reinberg,et al.  Cdk-activating kinase complex is a component of human transcription factor TFIIH , 1995, Nature.

[3]  K. Schulze-Osthoff,et al.  HIV‐1 Tat potentiates TNF‐induced NF‐kappa B activation and cytotoxicity by altering the cellular redox state. , 1995, The EMBO journal.

[4]  M. Dizdaroglu,et al.  Monomeric base damage products from adenine, guanine, and thymine induced by exposure of DNA to ultraviolet radiation. , 1995, Biochemistry.

[5]  Samuel H. Wilson,et al.  DNA Polymerase Conducts the Gap-filling Step in Uracil-initiated Base Excision Repair in a Bovine Testis Nuclear Extract (*) , 1995, The Journal of Biological Chemistry.

[6]  R. Wood,et al.  An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells , 1995, Molecular and cellular biology.

[7]  P. Cerutti,et al.  The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. , 1995, Chemistry & biology.

[8]  D. Mitchell,et al.  Enhanced photoproduct repair: its role in the DNA damage-resistance phenotype of human malignant melanoma cells. , 1995, Cancer research.

[9]  R. Lloyd,et al.  Unified catalytic mechanism for DNA glycosylases. , 1994, The Journal of biological chemistry.

[10]  A. Sancar.  Mechanisms of DNA excision repair. , 1994, Science.

[11]  C. Anderson,et al.  The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[12]  D. S. Hsu,et al.  Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[13]  S. Lippard,et al.  HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[14]  T. Todo,et al.  Cloning of a marsupial DNA photolyase gene and the lack of related nucleotide sequences in placental mammals. , 1994, Nucleic acids research.

[15]  S. West,et al.  XPG endonuclease makes the 3′ incision in human DNA nucleotide excision repair , 1994, Nature.

[16]  F. Alt,et al.  Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. , 1994, Science.

[17]  K. Ishizaki,et al.  Increased UV‐induced SCEs but normal repair of DNA damage in p53‐deficient mouse cells , 1994, International journal of cancer.

[18]  T. Ohmoto,et al.  Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. , 1994, Mutation research.

[19]  M. Saparbaev,et al.  Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[20]  R. Getts,et al.  Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. , 1994, The Journal of biological chemistry.

[21]  M. Lieber,et al.  Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. , 1994, Genes & development.

[22]  D. Averbeck,et al.  Activated ras oncogene and specifically acquired resistance to cisplatin in human mammary epithelial cells: induction of DNA cross-links and their repair. , 1994, Carcinogenesis.

[23]  K. Tanaka,et al.  Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. , 1994, The EMBO journal.

[24]  C. Harris,et al.  Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[25]  A. Fornace,et al.  Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[26]  H. Fraenkel-conrat,et al.  All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A. Sancar.  Structure and function of DNA photolyase. , 1994, Biochemistry.

[28]  B Demple,et al.  Repair of oxidative damage to DNA: enzymology and biology. , 1994, Annual review of biochemistry.

[29]  L. Mullenders,et al.  Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. , 1993, Nucleic acids research.

[30]  A. Grollman,et al.  Function of the zinc finger in Escherichia coli Fpg protein. , 1993, The Journal of biological chemistry.

[31]  C. Anderson,et al.  DNA damage and the DNA-activated protein kinase. , 1993, Trends in biochemical sciences.

[32]  S. Ledoux,et al.  Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. , 1993, The Journal of biological chemistry.

[33]  B. Ames,et al.  Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T. Kunkel,et al.  Replication of UV-irradiated DNA in human cell extracts: evidence for mutagenic bypass of pyrimidine dimers. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[35]  T. Yagi,et al.  Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients. , 1993, Cancer research.

[36]  G. de Murcia,et al.  Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role. , 1993, The Journal of biological chemistry.

[37]  F. Alt,et al.  Impairment of V(D)J recombination in double-strand break repair mutants. , 1993, Science.

[38]  P. Chambon,et al.  DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. , 1993, Science.

[39]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[40]  J. Hearst,et al.  DNA repair by eukaryotic nucleotide excision nuclease. Removal of thymine dimer and psoralen monoadduct by HeLa cell-free extract and of thymine dimer by Xenopus laevis oocytes. , 1993, The Journal of biological chemistry.

[41]  S. Caradonna,et al.  Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. , 1993, The Journal of biological chemistry.

[42]  M. Dizdaroglu.  Measurement of radiation-induced damage to DNA at the molecular level. , 1992, International journal of radiation biology.

[43]  M. Nance,et al.  Cockayne syndrome: review of 140 cases. , 1992, American journal of medical genetics.

[44]  J. Simon,et al.  A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[45]  P. Burgers,et al.  The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair , 1991, Journal of bacteriology.

[46]  J. Hearst,et al.  Removal of psoralen monoadducts and crosslinks by human cell free extracts. , 1991, Nucleic acids research.

[47]  B. Demple,et al.  Regulation of bacterial oxidative stress genes. , 1991, Annual review of genetics.

[48]  J. Jiricny,et al.  Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[49]  L. Mullenders,et al.  The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[50]  G. Chu,et al.  Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[51]  S. Hirschfeld,et al.  A constitutive damage-specific DNA-binding protein is synthesized at higher levels in UV-irradiated primate cells , 1990, Molecular and cellular biology.

[52]  S. Linn,et al.  Purification and characterization of UV endonucleases I and II from murine plasmacytoma cells. , 1989, Journal of Biological Chemistry.

[53]  S. Linn,et al.  DNA-repair reactions by purified HeLa DNA polymerases and exonucleases. , 1988, The Journal of biological chemistry.

[54]  P. Hanawalt,et al.  Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene , 1987, Cell.

[55]  K. Brookman,et al.  Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[56]  R. Setlow,et al.  Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens. , 1974, Cancer research.