The weight of scientific evidence in policy and law.

The term "weight of evidence" (WOE) appears in regulatory rules and decisions. However, there has been little discussion about the meaning, variations of use, and epistemic significance of WOE for setting health and safety standards. This article gives an overview of the role of WOE in regulatory science, discusses alternative views about the methodology underlying the concept, and places WOE in the context of the Supreme Court's decision in Daubert v Merrell Dow Pharmaceuticals, Inc (1993). I argue that whereas the WOE approach to evaluating scientific evidence is gaining favor among regulators, its applications in judicial processes may be in conflict with some interpretations of how the Daubert criteria for judging reliable evidence should be applied.

[1]  Michael E Ginevan,et al.  Updated weight of evidence for an association between adverse reproductive and developmental effects and exposure to disinfection by-products. , 2006, Regulatory toxicology and pharmacology : RTP.

[2]  S. Greenland,et al.  Causation and causal inference in epidemiology. , 2005, American journal of public health.

[3]  D. Michaels.  Scientific evidence and public policy. , 2005, American journal of public health.

[4]  R. Melnick.  A Daubert motion: a legal strategy to exclude essential scientific evidence in toxic tort litigation. , 2005, American journal of public health.

[5]  R. Clapp,et al.  Science and regulation: current impasse and future solutions. , 2005, American journal of public health.

[6]  G. Matanoski,et al.  Weight of evidence for an association between adverse reproductive and developmental effects and exposure to disinfection by-products: a critical review. , 2001, Regulatory toxicology and pharmacology : RTP.

[7]  M. DeBaun,et al.  Environmental exposure and cancer in children. A conceptual framework for the pediatrician. , 2001, Pediatric clinics of North America.

[8]  Susan Haack,et al.  An Epistemologist in the Bramble-Bush: At the Supreme Court with Mr. Joiner , 2001, Journal of health politics, policy and law.

[9]  C C Willhite,et al.  Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP). , 2001, Toxicology.

[10]  J. Giddings,et al.  The Need for Multiple Lines of Evidence for Predicting Site-Specific Ecological Effects , 2000 .

[11]  G. Elwyn,et al.  Judging the 'weight of evidence' in systematic reviews: introducing rigour into the qualitative overview stage by assessing Signal and Noise. , 2000, Journal of evaluation in clinical practice.

[12]  Joseph M. Culp,et al.  Integrating mesocosm experiments with field and laboratory studies to generate weight‐of‐evidence risk assessments for large rivers , 2000 .

[13]  M E Meek,et al.  Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[14]  D J Balding,et al.  When can a DNA profile be regarded as unique? , 1999, Science & justice : journal of the Forensic Science Society.

[15]  N. Roney,et al.  Site-specific consultation for a chemical mixture , 1999, Toxicology and industrial health.

[16]  E J Calabrese,et al.  A toxicologically based weight-of-evidence methodology for the relative ranking of chemicals of endocrine disruption potential. , 1997, Regulatory toxicology and pharmacology : RTP.

[17]  R J Kavlock,et al.  Endocrine disruptors and reproductive development: a weight-of-evidence overview. , 1997, The Journal of endocrinology.

[18]  Vern R. Walker.  RISK CHARACTERIZATION AND THE WEIGHT OF EVIDENCE : ADAPTING GATEKEEPING CONCEPTS FROM THE COURTS , 1996 .

[19]  D. Mitchell,et al.  Special report of the Massachusetts weight‐of‐evidence workgroup A weight‐of‐evidence approach for evaluating ecological risks , 1996 .

[20]  G. G. Bond,et al.  Weight of the evidence on the human carcinogenicity of 2,4-D* , 1991, Environmental health perspectives.

[21]  Gary James Jason,et al.  The Logic of Scientific Discovery , 1988 .

[22]  A. B. Hill.  The Environment and Disease: Association or Causation? , 1965, Proceedings of the Royal Society of Medicine.

[23]  T. Kuhn,et al.  The Structure of Scientific Revolutions. , 1964 .

[24]  M. Kendall,et al.  The Logic of Scientific Discovery. , 1959 .

[25]  J. Shearmur.  Karl Popper: The Logic of Scientific Discovery , 2005 .

[26]  Wellesley Site,et al.  What is an Ecological Risk Assessment ? , 2004 .

[27]  Eric P. Smith,et al.  Weight of Evidence ( WOE ) : Quantitative Estimation of Probability of Impact , 2002 .

[28]  T. McGarity.  Proposal for Linking Culpability and Causation to Ensure Corporate Accountability for Toxic Risks , 2001 .

[29]  Richard A. Chechile,et al.  Environmental decision making: a multidisciplinary perspective. , 1991 .