Optimal control of the moment of spontaneous tumor regression
暂无分享,去创建一个
This paper is concerned with the description of the spontaneous regression of a cancer tumor in mice. A model is suggested in which it is assumed that the strategy of resolution of a tumor is chosen by an organism in an optimal way. A goal function is introduced that has the sense of the work to be done by an organism so as to annihilate the cancer tumor. In the course of the solution of the originated minimization problem, it becomes possible to define the class of systems that involves the object under consideration with the preliminary accumulation of injuries in cancer cells. It is assumed that without such a preliminary accumulation of injuries, the immune action does not lead to the extinction of cancer cells.
[1] A. M. Hicks,et al. Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[2] H. Stam,et al. The spontaneous regression of cancer. A review of cases from 1900 to 1987. , 1990, Acta oncologica.
[3] M.-T. Chao,et al. DEGRADATION ANALYSIS AND RELATED TOPICS : SOME THOUGHTS AND A REVIEW , 1999 .