Dynamic and equilibrium swelling behaviour of pH-sensitive hydrogels containing 2-hydroxyethyl methacrylate.

The equilibrium and dynamic swelling behaviour of hydrogels containing methacrylic acid or various acrylamides was studied as a function of copolymer composition. In all cases, the comonomer was 2-hydroxyethyl methacrylate, methyl methacrylate or N-vinyl-2-pyrrolidone. It is shown that pH-sensitive behaviour with a wide range of swelling ratios could be obtained using a range of compositional changes. The dynamic swelling behaviour was a function of the acidity of the buffered solution.

[1]  Michal Ilavsky,et al.  Phase transition in swollen gels. 2. Effect of charge concentration on the collapse and mechanical behavior of polyacrylamide networks , 1982 .

[2]  J. Stejskal,et al.  Phase transition in swollen gels , 1987 .

[3]  N. Bikales.  Present and Future Directions of Basic Research on Polymeric Materials , 1987 .

[4]  Nicholas A. Peppas,et al.  A simple equation for description of solute release II. Fickian and anomalous release from swellable devices , 1987 .

[5]  T. Tanaka,et al.  Phase transition in ionic gels induced by copper complexation , 1985 .

[6]  N. Gaylord.  Poly(maleic Anhydride) , 1975 .

[7]  K. Ulbrich,et al.  Solution properties of drug carriers based on poly[N‐(2‐hydroxypropyl)methacrylamide] containing biodegradable bonds , 1987 .

[8]  J. Šulc,et al.  Intraocular biocompatibility of hydroxyethyl methacrylate and methacrylic acid copolymer/partially hydrolyzed poly(2-hydroxyethyl methacrylate). , 1987, Journal of biomedical materials research.

[9]  J. Kopeček,et al.  Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers. 3. Targeting by incorporation of galactosamine residues. Effect of route of administration , 1987 .

[10]  B D Ratner,et al.  Transport through crosslinked poly(2-hydroxyethyl methacrylate) hydrogel membranes. , 1973, Journal of biomedical materials research.

[11]  S. W. Kim,et al.  Permeation of water-soluble solutes through poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate) crosslinked with ethylene glycol dimethacrylate , 1980 .

[12]  H. Tanzawa,et al.  Mechanical properties of the soft contact lens of poly(methyl methacrylate-N-vinylpyrrolidone). , 1980, Journal of biomedical materials research.

[13]  N. Peppas,et al.  Effect of degree of crosslinking on water transport in polymer microparticles , 1985 .

[14]  Nicholas A. Peppas,et al.  Solute and penetrant diffusion in swellable polymers. IV. Semicrystalline, swelling-controlled release systems of poly(ethylene-co-vinyl alcohol) , 1986 .

[15]  P. Russo.  A perspective on reversible gels and related systems , 1987 .

[16]  N. Peppas,et al.  Bioadhesive analysis of controlled-release systems. III. Bioadhesive and release behavior of metronidazole-containing poly(acrylic acid)-hydroxypropyl methylcellulose systems , 1987 .

[17]  D. Eustace,et al.  Polymer compatibility and interpolymer association in the poly(acrylic acid)–polyacrylamide–water ternary system , 1988 .

[18]  D. T. Turner.  Water sorption of poly(methyl methacrylate): 1. Effects of molecular weight , 1987 .

[19]  A. L. Smolyanskii,et al.  Effect of complex formation on reactivity of acrylic and methacrylic acids in radical polymerization , 1985 .

[20]  R. A. M. Thomson.  Preparation of Ionic Polymers , 1986 .

[21]  M. Ilavský,et al.  Phase transition in swollen gels , 1982 .

[22]  S. K. Chatterjee,et al.  Influence of preferential solvation on the interpolymer complex formation between methacrylic acid-methacrylamide copolymer and poly(vinyl pyrrolidone) , 1986 .

[23]  S. Morgan,et al.  Water-soluble copolymers, 16. Studies of the behavior of acrylamide/N-(1,1-dimethyl-3-oxobutyl)acrylamide copolymers in aqueous salt solutions† , 1987 .

[24]  K. Dušek,et al.  Structure and elasticity of non-crystalline polymer networks , 1969 .

[25]  N. Peppas,et al.  Influence of copolymer composition on non‐fickian water transport through glassy copolymers , 1983 .

[26]  M. Jhon,et al.  Temperature effect on the permeation through poly(2‐hydroxyethyl methacrylate) membrane , 1982 .

[27]  E. Eckstein,et al.  Effects of low levels of methacrylic acid on the swelling behavior of poly(2-hydroxyethyl methacrylate) , 1984 .

[28]  N. Peppas.  Hydrogels in Medicine and Pharmacy , 1987 .

[29]  K. Ishihara,et al.  Insulin Permeation through Amphiphilic Polymer Membranes Having 2-Hydroxyethyl Methacrylate Moiety , 1984 .

[30]  J. Kopeček,et al.  Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers: Pinocytosis by rat visceral yolk sacs and rat intestine cultured in vitro. Effect of molecular weight on uptake and intracellular degradation , 1987 .

[31]  J. Andrade,et al.  Note to the editorEffect of water and tacticity on the glass transition temperature of poly(2-hydroxyethyl methacrylate) , 1978 .

[32]  K. Dušek,et al.  Hydrophilic gels based on copolymers of 2‐hydroxyethyl methacrylate with methacrylamide and acrylamide , 1975 .

[33]  N. Peppas,et al.  Solute and penetrant diffusion in swellable polymers: VI. The Deborah and swelling interface numbers as indicators of the order of biomolecular release , 1986 .