Resorption rates of 2 commercially available bioresorbable membranes. A histomorphometric study in a rabbit model.

The respective resorption rates of recently commercialized collagen versus polylactic acid-citric acid ester membranes were compared. 16 rabbits were implanted with 2 mm x 4 mm pieces of membrane of both types in the alveolar mucosa just apically to the incisors on either side of the mouth. 1 animal was sacrificed on day 0, just after the operation. The others were sacrificed at 1, 2, 3, 5, 7, 9 and 12 weeks. The specimens were prepared for histologic examination. Observations showed that the cross-linked collagen membranes induced severe inflammation and were resorbed within 2 weeks. The polylactic acid-citric acid ester polymer barriers produced a much more moderate infiltrate and were still not totally resorbed at 12 weeks. Although resorption rates in the rabbit may not be similar to those observed in humans, it seems that the durability of the polymer barrier is more adequate for guided tissue regeneration than the cross-linked collagen.

[1]  T. Takata,et al.  Periodontal tissue regeneration on the surface of synthetic hydroxyapatite implanted into root surface. , 1995, Journal of periodontology.

[2]  H. Falk,et al.  Clinical use of a bioresorbable matrix barrier in guided tissue regeneration therapy. Case series. , 1994, Journal of periodontology.

[3]  H. Chen,et al.  Response of regenerative tissues to plaque: a histological study in monkeys. , 1994, Journal of periodontology.

[4]  R. H. Johnson,et al.  Effects of antibiotic treatment on clinical conditions with guided tissue regeneration: one-year results. , 1994, Journal of periodontology.

[5]  R. Frank,et al.  Periodontal guided tissue regeneration with a new resorbable polylactic acid membrane. , 1994, Journal of periodontology.

[6]  U. Wikesjö,et al.  Periodontal repair in dogs: space provision by reinforced ePTFE membranes enhances bone and cementum regeneration in large supraalveolar defects. , 1994, Journal of periodontology.

[7]  L. Flores-de-Jacoby,et al.  Experiences with guided tissue regeneration in the treatment of advanced periodontal disease. A clinical re-entry study. Part I. Vertical, horizontal and horizontal periodontal defects. , 1994, Journal of clinical periodontology.

[8]  G. Pini-Prato,et al.  Periodontal regeneration of human intrabony defects. IV. Determinants of healing response. , 1993, Journal of periodontology.

[9]  Nancy E. Barton,et al.  Collagen membrane barrier therapy to guide regeneration in Class II furcations in humans. , 1993, Journal of periodontology.

[10]  K. Leknes,et al.  Ultrastructure of plaque associated with polytetrafluoroethylene (PTFE) membranes used for guided tissue regeneration. , 1993, Journal of clinical periodontology.

[11]  N. Lang,et al.  Remodelling of periodontal tissues adjacent to sites treated according to the principles of guided tissue regeneration (GTR). , 1992, Journal of clinical periodontology.

[12]  P. Dowell,et al.  Freeze-dried, cross-linked bovine type I collagen: analysis of properties. , 1992, Journal of periodontology.

[13]  C. Ropert,et al.  Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats. , 1992, Biomaterials.

[14]  M. Minabe,et al.  A critical review of the biologic rationale for guided tissue regeneration. , 1991, Journal of periodontology.

[15]  K. Warrer,et al.  Formation of a periodontal ligament around titanium implants. , 1990, Journal of periodontology.

[16]  K. Selvig,et al.  Scanning electron microscopic observations of cell populations and bacterial contamination of membranes used for guided periodontal tissue regeneration in humans. , 1990, Journal of periodontology.

[17]  P. Menasché,et al.  Use of the acyl azide method for cross-linking collagen-rich tissues such as pericardium. , 1990, Journal of biomedical materials research.

[18]  H. Tal,et al.  Collagen membranes prevent apical migration of epithelium and support new connective tissue attachment during periodontal wound healing in dogs. , 1989, Journal of periodontal research.

[19]  M. Minabe,et al.  The effect of various concentrations of collagen barrier on periodontal wound healing. , 1989, Journal of periodontology.

[20]  I. Aukhil,et al.  Periodontal ligament cell kinetics following experimental regenerative procedures. , 1988, Journal of clinical periodontology.

[21]  J. Egelberg,et al.  Treatment of intraosseous periodontal defects with a combined adjunctive therapy of citric acid conditioning, bone grafting, and placement of collagenous membranes. , 1988, Journal of clinical periodontology.

[22]  G. Koch,et al.  Progenitor cell kinetics during guided tissue regeneration in experimental periodontal wounds. , 1988, Journal of periodontal research.

[23]  C. Batich,et al.  New attachment formation following controlled tissue regeneration using biodegradable membranes. , 1988, Journal of periodontology.

[24]  E. Rosenberg,et al.  Root isolation for new attachment procedures. A surgical and suturing method: three case reports. , 1987, Journal of periodontology.

[25]  J. Lindhe,et al.  Guided tissue regeneration in the treatment of furcation defects in man. , 1987, Journal of clinical periodontology.

[26]  T. Karring,et al.  New attachment formation by guided tissue regeneration. , 1987, Journal of periodontal research.

[27]  C. Suggs,et al.  Guided tissue regeneration. An experimental procedure in beagle dogs. , 1986, Journal of periodontology.

[28]  J. Wennström,et al.  New attachment formation in the human periodontium by guided tissue regeneration. Case reports. , 1986, Journal of clinical periodontology.

[29]  G. E. Visscher,et al.  Biodegradation of and tissue reaction to poly(DL-lactide) microcapsules. , 1986, Journal of biomedical materials research.

[30]  T. Karring,et al.  New attachment formation as the result of controlled tissue regeneration. , 1984, Journal of clinical periodontology.

[31]  I. Aukhil,et al.  An experimental study of new attachment procedure in beagle dogs. , 1983, Journal of periodontal research.

[32]  T. Karring,et al.  New attachment following surgical treatment of human periodontal disease. , 1982, Journal of clinical periodontology.

[33]  T. Karring,et al.  The regenerative potential of the periodontal ligament. An experimental study in the monkey. , 1982, Journal of clinical periodontology.

[34]  A H Melcher,et al.  On the repair potential of periodontal tissues. , 1976, Journal of periodontology.