OBJECTIVES
The objective of this study was to assess how often St. John's wort (SJW) is prescribed with medications that may interact dangerously with it.
DESIGN
The study design was a retrospective analysis of nationally representative data from the National Ambulatory Medical Care Survey.
SETTINGS
The study setting was U.S. nonfederal outpatient physician offices.
SUBJECTS
Those prescribed SJW between 1993 and 2010 were the subjects.
OUTCOME MEASURES
The outcome measures were medications co-prescribed with SJW.
RESULTS
Twenty-eight percent (28%) of SJW visits involved a drug that has potentially dangerous interaction with SJW. These included selective serotonin reuptake inhibitors, benzodiazepines, warfarin, statins, verapamil, digoxin, and oral contraceptives.
CONCLUSIONS
SJW is frequently used in potentially dangerous combinations. Physicians should be aware of these common interactions and warn patients appropriately.
[1]
S. Shi,et al.
Drug Interactions with Herbal Medicines
,
2012,
Clinical Pharmacokinetics.
[2]
F. Borrelli,et al.
Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations
,
2009,
The AAPS Journal.
[3]
K. Clauson,et al.
Bmc Complementary and Alternative Medicine Clinically Relevant Safety Issues Associated with St. John's Wort Product Labels
,
2008
.
[4]
H. Derendorf,et al.
Hyperforin in St. John’s wort drug interactions
,
2006,
European Journal of Clinical Pharmacology.
[5]
J. Davidson,et al.
Psychiatric disorders in primary care patients receiving complementary medical treatments.
,
1998,
Comprehensive psychiatry.