A Histologically Visible Representation of the Fingers and Palm in Primate Area 3 b and its Immutability Following Long-term

sensory cortex (area 3b) of owl monkeys in brain sections cut parallel to the surface and stained for myelin. A mediolateral row of five ovals, separated by myelin-light septa, represents digits and corresponds precisely with cortical sites activated by light touch on individual digits in microelectrode recordings. A number of caudal ovals relate to pads of the palm. A more distinct septum separates the hand from the more lateral face representation. Within the face representation, two large myelin-dense ovals can be identified that are activated by the upper or lower face in a caudo-rostral sequence. Accidental finger loss or dorsal column section, deafferentations that result in reorganization of the physiological map in area 3b, do not alter the morphological map. The proportions for each digit and palm in the morphological map do not vary across normal and deafferented animals. Similar isomorphs were also seen in area 3b of squirrel and macaque monkeys. We conclude that the anatomical isomorph for the body surface representation in area 3b is a reliable reflection of normal cortical organization and may be a common feature of the primate area 3b. The isomorph can provide a reference in studies of somatotopic reorganization.

[1]  J. Kaas,et al.  Reorganization of Somatosensory Cortex After Nerve and Spinal Cord Injury. , 1998, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[2]  Jon H. Kaas,et al.  Deactivation and reactivation of somatosensory cortex after dorsal spinal cord injury , 1997, Nature.

[3]  J. Kaas,et al.  Organization of somatosensory cortex and distribution of corticospinal neurons in the eastern mole (Scalopus aquaticus) , 1997, The Journal of comparative neurology.

[4]  P. Manger,et al.  Representation of face and intra‐oral structures in area 3b of macaque monkey somatosensory cortex , 1996, The Journal of comparative neurology.

[5]  J. Kaas,et al.  Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[6]  E G Jones,et al.  Representation of the face and intraoral structures in area 3b of the squirrel monkey (Saimiri sciureus) somatosensory cortex, with special reference to the ipsilateral representation , 1995, The Journal of comparative neurology.

[7]  Xiaoqin Wang,et al.  Remodelling of hand representation in adult cortex determined by timing of tactile stimulation , 1995, Nature.

[8]  L. Krubitzer.  The organization of neocortex in mammals: are species differences really so different? , 1995, Trends in Neurosciences.

[9]  J. Kaas,et al.  Limits on plasticity in somatosensory cortex of adult rats: hindlimb cortex is not reactivated after dorsal column section. , 1995, Journal of neurophysiology.

[10]  J. Kaas,et al.  Organization of the somatosensory cortex of the star‐nosed mole , 1995, The Journal of comparative neurology.

[11]  J. Pettigrew,et al.  Organization of somatosensory cortex in monotremes: In search of the prototypical plan , 1995, The Journal of comparative neurology.

[12]  F. Ebner,et al.  An innocuous bias in whisker use in adult rats modifies receptive fields of barrel cortex neurons , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[13]  B. Schlaggar,et al.  Early development of the somatotopic map and barrel patterning in rat somatosensory cortex , 1994, The Journal of comparative neurology.

[14]  C. Gilbert,et al.  Axonal sprouting accompanies functional reorganization in adult cat striate cortex , 1994, Nature.

[15]  R. Rhoades,et al.  Serotonin 1B receptors form a transient vibrissa-related pattern in the primary somatosensory cortex of the developing rat. , 1992, Brain research. Developmental brain research.

[16]  G. Recanzone,et al.  Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. , 1992, Journal of neurophysiology.

[17]  J. Kaas,et al.  Ocular dominance columns in area 17 of Old World macaque and talapoin monkeys: Complete reconstructions and quantitative analyses , 1992, Visual Neuroscience.

[18]  D. Baylor,et al.  Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina. , 1991, Science.

[19]  L A Krubitzer,et al.  The organization and connections of somatosensory cortex in marmosets , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  H. Killackey,et al.  Expansion of the Central Hindpaw Representation Following Fetal Forelimb Removal in the Rat , 1989, The European journal of neuroscience.

[21]  Karl F. Jensen,et al.  Evidence for two complementary patterns of thalamic input to the rat somatosensory cortex , 1988, Brain Research.

[22]  M. N. Wallace.  Histochemical demonstration of sensory maps in the rat and mouse cerebral cortex , 1987, Brain Research.

[23]  J. Kaas,et al.  Variability in hand surface representations in areas 3b and 1 in adult owl and squirrel monkeys , 1987, The Journal of comparative neurology.

[24]  H. Killackey,et al.  The organization and mutability of the forepaw and hindpaw representations in the somatosensory cortex of the neonatal rat , 1987, The Journal of comparative neurology.

[25]  R B Tootell,et al.  Topography of cytochrome oxidase activity in owl monkey cortex , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[26]  D. Simons,et al.  Metabolic activity in SmI cortical barrels of adult rats is dependent on patterned sensory stimulation of the mystacial vibrissae , 1985, Brain Research.

[27]  R W Guillery,et al.  Abnormal central visual pathways in the brain of an albino green monkey (Cercopithecus aethiops) , 1984, The Journal of comparative neurology.

[28]  M. Cynader,et al.  Somatosensory cortical map changes following digit amputation in adult monkeys , 1984, The Journal of comparative neurology.

[29]  H. Killackey,et al.  Evidence for the complementary organization of callosal and thalamic connections within rat somatosensory cortex , 1984, Brain Research.

[30]  J. Kaas,et al.  The relation of corpus callosum connections to architectonic fields and body surface maps in sensorimotor cortex of new and old world monkeys , 1983, The Journal of comparative neurology.

[31]  D J Felleman,et al.  Recovery of normal topography in the somatosensory cortex of monkeys after nerve crush and regeneration. , 1983, Science.

[32]  D. J. Felleman,et al.  Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation , 1983, Neuroscience.

[33]  H. Killackey,et al.  The sensitive period in the development of the trigeminal system of the neonatal rat , 1980, The Journal of comparative neurology.

[34]  M. Sur,et al.  Representations of the body surface in postcentral parietal cortex of Macaca fascicularis , 1980, The Journal of comparative neurology.

[35]  H. Killackey,et al.  The development of vibrissae representation in subcortical trigeminal centers of the neonatal rat , 1979, The Journal of comparative neurology.

[36]  M. Wong-Riley.  Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry , 1979, Brain Research.

[37]  H. Killackey,et al.  Anatomical correlates of the forelimb in the ventrobasal complex and the cuneate nucleus of the neonatal rat , 1978, Brain Research.

[38]  C. Welker.  Receptive fields of barrels in the somatosensory neocortex of the rat , 1976, The Journal of comparative neurology.

[39]  T. Woolsey,et al.  Comparative anatomical studies of the Sml face cortex with special reference to the occurrence of “barrels” in layer IV , 1975, The Journal of comparative neurology.

[40]  J. Allman,et al.  Discontinuities in the dorsal lateral geniculate nucleus corresponding to the optic disc: A comparative study , 1973, The Journal of comparative neurology.

[41]  W. L. Weller.  Barrels in somatic sensory neocortex of the marsupial Trichosurus vulpecula (brush-tailed possum). , 1972, Brain research.

[42]  W. Welker,et al.  Somatic sensory representation in the cerebral cortex of the racoon (Procyon lotor) , 1959, The Journal of comparative neurology.

[43]  E. D. Adrian,et al.  Afferent discharges to the cerebral cortex from peripheral sense organs , 1941, The Journal of physiology.

[44]  W. Penfield,et al.  SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION , 1937 .

[45]  P Bard,et al.  CORTICAL REPRESENTATION OF TACTILE SENSIBILITY AS INDICATED BY CORTICAL POTENTIALS. , 1937, Science.

[46]  G Mann,et al.  ON THE THALAMUS * , 1905, British medical journal.

[47]  J. Kaas.  The reorganization of sensory and motor maps after injury in adult mammals , 2000 .

[48]  J. Kaas,et al.  Plasticity of Somatosensory Cortex in Primates , 1997 .

[49]  Kenneth C. Catania.  Magnified cortex in star-nosed moles , 1995 .

[50]  Vivien A. Casagrande,et al.  The Afferent, Intrinsic, and Efferent Connections of Primary Visual Cortex in Primates , 1994 .

[51]  J. Kaas,et al.  Areal distributions of cortical neurons projecting to different levels of the caudal brain stem and spinal cord in rats. , 1990, Somatosensory & motor research.

[52]  J. Johnson.  Comparative Development of Somatic Sensory Cortex , 1990 .

[53]  Alan Peters,et al.  Comparative structure and evolution of cerebral cortex , 1990 .

[54]  M Sur,et al.  The arbors of axons terminating in middle cortical layers of somatosensory area 3b in owl monkeys. , 1989, Somatosensory & motor research.

[55]  J. Kaas,et al.  Consistent features of the representation of the hand in area 3b of macaque monkeys. , 1987, Somatosensory research.

[56]  F. Gallyas.  Silver staining of myelin by means of physical development. , 1979, Neurological research.

[57]  T. Woolsey,et al.  The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units. , 1970, Brain research.