The ancestral selection graph under strong directional selection.

The ancestral selection graph (ASG) was introduced by  Neuhauser and Krone (1997) in order to study populations of constant size which evolve under selection. Coalescence events, which occur at rate 1 for every pair of lines, lead to joint ancestry. In addition, splitting events in the ASG at rate α, the scaled selection coefficient, produce possible ancestors, such that the real ancestor depends on the ancestral alleles. Here, we use the ASG in the case without mutation in order to study fixation of a beneficial mutant. Using our main tool, a reversibility property of the ASG, we provide a new proof of the fact that a beneficial allele fixes roughly in time (2logα)/α if α is large.

[1]  A. Wakolbinger,et al.  An approximate sampling formula under genetic hitchhiking , 2005, math/0503485.

[2]  J. Hermisson,et al.  Soft Sweeps , 2005, Genetics.

[3]  D. Aldous Deterministic and stochastic models for coalescence (aggregation and coagulation): a review of the mean-field theory for probabilists , 1999 .

[4]  S. Mano Duality, ancestral and diffusion processes in models with selection. , 2008, Theoretical population biology.

[5]  T. Lindvall Lectures on the Coupling Method , 1992 .

[6]  J. Wakeley,et al.  The conditional ancestral selection graph with strong balancing selection. , 2009, Theoretical population biology.

[7]  N L Kaplan,et al.  The "hitchhiking effect" revisited. , 1989, Genetics.

[8]  Stephen M. Krone,et al.  Ancestral Processes with Selection , 1997, Theoretical population biology.

[9]  T. Kurtz Approximation of Population Processes , 1987 .

[10]  T. Shiga Diffusion processes in population genetics , 1981 .

[11]  Stephen M. Krone,et al.  The genealogy of samples in models with selection. , 1997, Genetics.

[12]  P. Fearnhead The common ancestor at a nonneutral locus , 2002, Journal of Applied Probability.

[13]  P. Pfaffelhuber,et al.  Tree-valued Fleming–Viot dynamics with mutation and selection , 2011, 1101.0759.

[14]  W Stephan,et al.  A population genomic approach to map recent positive selection in model species , 2008, Molecular ecology.

[15]  Frank Kelly,et al.  Reversibility and Stochastic Networks , 1979 .

[16]  T. Kurtz Limit theorems for sequences of jump Markov processes approximating ordinary differential processes , 1971, Journal of Applied Probability.

[17]  J. Pritchard Are rare variants responsible for susceptibility to complex diseases? , 2001, American journal of human genetics.

[18]  T. E. Harris,et al.  The Theory of Branching Processes. , 1963 .

[19]  R. Durrett,et al.  Random partitions approximating the coalescence of lineages during a selective sweep , 2004, math/0411069.

[20]  T. Shiga,et al.  Stationary states and their stability of the stepping stone model involving mutation and selection , 1986 .

[21]  Peter Donnelly,et al.  Genealogical processes for Fleming-Viot models with selection and recombination , 1999 .

[22]  R. Hudson Properties of a neutral allele model with intragenic recombination. , 1983, Theoretical population biology.

[23]  Motoo Kimura,et al.  Some Problems of Stochastic Processes in Genetics , 1957 .

[24]  Neil O'Connell Yule process approximation for the skeleton of a branching process , 1993 .