Thermoforming of Film‐Based Biomedical Microdevices

For roughly ten years now, a new class of polymer micromoulding processes comes more and more into the focus both of the microtechnology and the biomedical engineering community. These processes can be subsumed under the term "microthermoforming". In microthermoforming, thin polymer films are heated to a softened, but still solid state and formed to thin-walled microdevices by three-dimensional stretching. The high material coherence during forming is in contrast to common polymer microreplication processes where the material is processed in a liquid or flowing state. It enables the preservation of premodifications of the film material. In this progress report, we review the still young state of the art of microthermoforming technology as well as its first applications. So far, the applications are mainly in the biomedical field. They benefit from the fact that thermoformed microdevices have unique properties resulting from their special, unusual morphology. The focus of this paper is on the impact of the new class of micromoulding processes and the processed film materials on the characteristics of the moulded microdevices and on their applications.

[1]  George M. Whitesides,et al.  Solvent‐assisted microcontact molding: A convenient method for fabricating three‐dimensional structures on surfaces of polymers , 1997 .

[2]  Wilhelm Pfleging,et al.  A chip-based platform for the in vitro generation of tissues in three-dimensional organization. , 2007, Lab on a chip.

[3]  Roland Zengerle,et al.  Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA). , 2010, Lab on a chip.

[4]  C. Effenhauser,et al.  Integrated capillary electrophoresis on flexible silicone microdevices:  analysis of DNA restriction fragments and detection of single DNA molecules on microchips. , 1997, Analytical chemistry.

[5]  Josep Samitier,et al.  Complex microstructured 3D surfaces using chitosan biopolymer. , 2009, Small.

[6]  Matthias Worgull,et al.  Hot Embossing: Theory and Technology of Microreplication , 2009 .

[7]  S. Chou,et al.  Imprint Lithography with 25-Nanometer Resolution , 1996, Science.

[8]  J. Giboz,et al.  Microinjection molding of thermoplastic polymers: a review , 2007 .

[9]  Sumona Sarkar,et al.  Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications. , 2006, Biomaterials.

[10]  H. Dreuth,et al.  Thermoplastic structuring of thin polymer films , 1999 .

[11]  M. Heckele,et al.  Review on micro molding of thermoplastic polymers , 2004 .

[12]  Pramod V. Mahajan,et al.  Applications of Plastic Films for Modified Atmosphere Packaging of Fruits and Vegetables: A Review , 2009 .

[13]  Th. Schaller,et al.  Low-cost thermoforming of micro fluidic analysis chips , 2002 .

[14]  K. Ikuta,et al.  Artificial Capillary Network Chip for in Vitro 3D Tissue Culture , 2007, TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference.

[15]  D. Yao,et al.  Cold forging method for polymer microfabrication , 2004 .

[16]  K. Ikuta,et al.  “Membrane micro emboss following excimer laser ablation (MeME-X) process” for pressure-driven micro active catheter , 2008, 2008 IEEE 21st International Conference on Micro Electro Mechanical Systems.

[17]  K. Ikuta,et al.  Real three dimensional micro fabrication using stereo lithography and metal molding , 1993, [1993] Proceedings IEEE Micro Electro Mechanical Systems.

[18]  E Gottwald,et al.  Flexible fluidic microchips based on thermoformed and locally modified thin polymer films. , 2008, Lab on a chip.

[19]  E Gottwald,et al.  Microthermoforming as a novel technique for manufacturing scaffolds in tissue engineering (CellChips). , 2004, IEE proceedings. Nanobiotechnology.

[20]  G. Whitesides,et al.  Fabrication of three‐dimensional micro‐structures: Microtransfer molding , 1996 .

[21]  F Schneider,et al.  A tissue-like culture system using microstructures: influence of extracellular matrix material on cell adhesion and aggregation. , 1999, Journal of biomechanical engineering.

[22]  Andreas Schober,et al.  Microfluidics and biosensors as tools for NanoBioSystems research with applications in the “Life Science” , 2010 .

[23]  Matthias Worgull,et al.  Microthermoforming of nanostructured polymer films: a new bonding method for the integration of nanostructures in 3-dimensional cavities , 2009, 2009 Symposium on Design, Test, Integration & Packaging of MEMS/MOEMS.

[24]  V. Piotter,et al.  Performance and simulation of thermoplastic micro injection molding , 2002 .

[25]  Eric Gottwald,et al.  Microstructured scaffolds for liver tissue cultures of high cell density: Morphological and biochemical characterization of tissue aggregates , 2005, Journal of cellular biochemistry.

[26]  Jan Haisma,et al.  Mold‐assisted nanolithography: A process for reliable pattern replication , 1996 .

[27]  Xu,et al.  Room-temperature imprinting method for plastic microchannel fabrication , 2000, Analytical chemistry.

[28]  G. Whitesides,et al.  Complex Optical Surfaces Formed by Replica Molding Against Elastomeric Masters , 1996, Science.

[29]  J B Findlay,et al.  Automated closed-vessel system for in vitro diagnostics based on polymerase chain reaction. , 1993, Clinical chemistry.

[30]  Anthony L. Parsons,et al.  Modified atmosphere packaging technology: A review , 1995 .

[31]  Claas Müller,et al.  Replication technologies for HARM devices: status and perspectives , 2008 .

[32]  G. Whitesides,et al.  Polymer microstructures formed by moulding in capillaries , 1995, Nature.

[33]  Roland Zengerle,et al.  Lab-on-a-Foil: microfluidics on thin and flexible films. , 2010, Lab on a chip.

[34]  A Ruzzu,et al.  Positioning system for catheter tips based on an active microvalve system , 1998 .

[35]  R. Truckenmüller,et al.  Microthermoforming of flexible, not-buried hollow microstructures for chip-based life sciences applications. , 2004, IEE proceedings. Nanobiotechnology.

[36]  Matthias Wessling,et al.  Phase Separation Micromolding—PSμM , 2003 .

[37]  Bernke J Papenburg,et al.  One-step fabrication of porous micropatterned scaffolds to control cell behavior. , 2007, Biomaterials.

[38]  Walter Bacher,et al.  Hot embossing - The molding technique for plastic microstructures , 1998 .

[39]  V. Piotter,et al.  Injection molding and related techniques for fabrication of microstructures , 1997 .

[40]  Axel Blau,et al.  Spatially controlled cell adhesion on three-dimensional substrates , 2010, Biomedical microdevices.

[41]  S. Giselbrecht,et al.  3D tissue culture substrates produced by microthermoforming of pre-processed polymer films , 2006, Biomedical microdevices.

[42]  Donggang Yao,et al.  Rubber-assisted micro forming of polymer thin films , 2008 .

[43]  H. Reinecke,et al.  Low Cost Production of Disposable Microfluidics by Blister Packaging Technology , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.