The proposed terminology ‘A1c-derived average glucose’ is inherently imprecise and should not be adopted

The proposed use of a more precise standard for glycated (A1c) and non-glycated haemoglobin would lead to an A1c value, when expressed as a percentage, that is lower than that currently in use. One approach advocated to address the potential confusion that would ensue is to replace ‘HbA1c’ with a new term, ‘A1c-derived average glucose.’ We review evidence from several sources suggesting that A1c is, in fact, inherently imprecise as a measure of average glucose, so that the proposed terminology should not be adopted.

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