Review of fracture experience during treatment of Paget's disease of bone with etidronate disodium (EHDP).

For approximately 50 years after Sir James Paget first described the disease that now carries his name, the incidence of fracture as a complication of the disease was considered rare and received little attention. Since 1925, that view has changed, and it is believed that fractures in patients with Paget’s disease are common. Dickson et a1.I’ reported that pathologic fracture was the most frequent complication associated with Paget’s disease, an observation strongly supported by Lake” and Barry’ in subsequent reviews. In the last decade, promising therapy for Paget’s disease has become available in the