Metabolically healthy obesity increased diabetes incidence in a middle‐aged and elderly Chinese population

We examined the association between metabolically healthy obese (MHO) and diabetes incidence in a middle‐aged and elderly population and whether the association differed by the presence of nonalcoholic fatty liver disease (NAFLD).

[1]  C. Ortega-Loubon,et al.  Obesity and its cardiovascular effects , 2019, Diabetes/metabolism research and reviews.

[2]  E. R. van den Heuvel,et al.  Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk , 2019, Journal of the American Heart Association.

[3]  J. Batsis,et al.  Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies , 2018, Nature Reviews Endocrinology.

[4]  Miao Liu,et al.  Distribution of metabolic/obese phenotypes and association with diabetes: 5 years’ cohort based on 22,276 elderly , 2018, Endocrine.

[5]  E. Bonora,et al.  Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis , 2018, Diabetes Care.

[6]  K. Toulis,et al.  Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women. , 2017, Journal of the American College of Cardiology.

[7]  Tangchun Wu,et al.  Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men , 2017, PloS one.

[8]  Joshua A. Salomon,et al.  Health Effects of Overweight and Obesity in 195 Countries over 25 Years. , 2017, The New England journal of medicine.

[9]  F. Hu,et al.  Bidirectional association between nonalcoholic fatty liver disease and type 2 diabetes in Chinese population: Evidence from the Dongfeng-Tongji cohort study , 2017, PloS one.

[10]  Yoosoo Chang,et al.  Metabolically healthy obesity is associated with an increased risk of diabetes independently of nonalcoholic fatty liver disease , 2016, Obesity.

[11]  Fritz Schick,et al.  Phenotypes of prediabetes and stratification of cardiometabolic risk. , 2016, The lancet. Diabetes & endocrinology.

[12]  Hong-Kyu Kim,et al.  Fatty liver index is a risk determinant of incident type 2 diabetes in a metabolically healthy population with obesity , 2016, Obesity.

[13]  Tran Quoc Bao,et al.  Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants , 2016, The Lancet.

[14]  S. Sharp,et al.  Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis , 2015, Diabetes Care.

[15]  W. Jia,et al.  Comparison of the effect of ‘metabolically healthy but obese’ and ‘metabolically abnormal but not obese’ phenotypes on development of diabetes and cardiovascular disease in Chinese , 2015, Endocrine.

[16]  H. Yki-Järvinen Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. , 2014, The lancet. Diabetes & endocrinology.

[17]  Tangchun Wu,et al.  The effects of midday nap duration on the risk of hypertension in a middle-aged and older Chinese population: a preliminary evidence from the Tongji-Dongfeng Cohort Study, China , 2014, Journal of hypertension.

[18]  H. Gerstein,et al.  Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults , 2014, Diabetes Care.

[19]  K. Fujihara,et al.  Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20). , 2014, The Journal of clinical endocrinology and metabolism.

[20]  Eric J. Brunner,et al.  Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study , 2014, European heart journal.

[21]  M. Kivimaki,et al.  Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies , 2014, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[22]  E. Rimm,et al.  Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants , 2014, The Lancet.

[23]  M. Carnethon,et al.  The Obesity Paradox in Diabetes , 2014, Current Cardiology Reports.

[24]  B. Zinman,et al.  Are Metabolically Healthy Overweight and Obesity Benign Conditions? , 2013, Annals of Internal Medicine.

[25]  T. Gill,et al.  Diabetes and Cardiovascular Disease Outcomes in the Metabolically Healthy Obese Phenotype , 2013, Diabetes Care.

[26]  F. Hu,et al.  Cohort Profile: the Dongfeng-Tongji cohort study of retired workers. , 2013, International journal of epidemiology.

[27]  S. Czernichow,et al.  Metabolically Healthy Obesity and Risk of Mortality , 2013, Diabetes Care.

[28]  C. Gutiérrez‐Repiso,et al.  Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study. , 2013, The Journal of clinical endocrinology and metabolism.

[29]  Eliseo Guallar,et al.  Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta‐analysis , 2011, Hepatology.

[30]  J. Stevens,et al.  Associations between gender, age and waist circumference , 2011, European Journal of Clinical Nutrition.

[31]  Lungen Lu,et al.  Guidelines for the diagnosis and management of nonalcoholic fatty liver disease: Update 2010 , 2011, Journal of digestive diseases.

[32]  A. Gasbarrini,et al.  Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease. A decalogue from the Italian Association for the Study of the Liver (AISF) Expert Committee. , 2010, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[33]  P. O S I T I O N S T A T E M E N T,et al.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[34]  G. Musso,et al.  Should Nonalcoholic Fatty Liver Disease Be Included in the Definition of Metabolic Syndrome? , 2008, Diabetes Care.

[35]  Ralph B D'Agostino,et al.  Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. , 2006, The Journal of clinical endocrinology and metabolism.

[36]  Paul Zimmet,et al.  The metabolic syndrome—a new worldwide definition , 2005, The Lancet.

[37]  조남욱 전자/제조업의 Collaboration 전략 , 2003 .

[38]  P. Angulo,et al.  Nonalcoholic fatty liver disease. , 2002, Revista de gastroenterologia de Mexico.

[39]  Bei-fan Zhou Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. , 2002, Biomedical and environmental sciences : BES.

[40]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[41]  M. Fukui,et al.  Metabolically healthy obesity without fatty liver and risk of incident type 2 diabetes: A meta-analysis of prospective cohort studies. , 2018, Obesity research & clinical practice.

[42]  W. Doehner Metabolically Healthy Obesity and Risk of Mortality:DoestheDefinitionofMetabolic Health Matter? Diabetes Care , 2014 .

[43]  Youming Li,et al.  Guidelines for the diagnosis and management of nonalcoholic fatty liver disease : Update 2010 ( Published in Chinese on Chinese , 2011 .

[44]  J. Ekoé,et al.  Diagnosis and Classification of Diabetes Mellitus , 2019, Encyclopedia of Endocrine Diseases.

[45]  J. Mckenney,et al.  Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). , 2001, JAMA.