Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China

Pharmaceuticals and personal care products (PPCPs) have been regarded as an emerging problem in the surface water environment in the past few decades. In China, although related studies were initiated several years ago, an increasing number of studies on this topic have been conducted in recent years. These studies have expanded knowledge of their occurrence, behavior and associated risk in the surface water environment in China. This review compiles the most recent literature related to the studies of PPCPs in the surface water environment in China. It includes PPCP occurrence in surface water and sediments, their geographical distribution, and outcomes of the associated risk assessment. It shows that antibiotics have received much more attention in both surface water and sediments than other PPCPs. Compared to other countries; most antibiotics in the collected sediments in China showed higher contamination levels. Many more study areas have been covered in recent years; however, attention has been given to only specific areas. Environmental risk assessment based on risk quotients indicated that sulfamethoxazole presents the most significant environmental risk to relevant aquatic organisms; followed by ofloxacin, ciprofloxacin, enrofloxacin, 17α-ethynylestradiol, ibuprofen and diclofenac. Despite limited research on the environmental risk assessment of PPCPs in sediments, higher risks posed by PPCPs in the sediments rather than surface water were identified highlighting the need for further risk assessment of PPCPs in sediment samples.

[1]  Ran Tao,et al.  Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC-MS/MS. , 2010, The Science of the total environment.

[2]  Gan Zhang,et al.  Occurrence and risks of antibiotics in the Laizhou Bay, China: impacts of river discharge. , 2012, Ecotoxicology and environmental safety.

[3]  Gan Zhang,et al.  Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities. , 2012, Marine environmental research.

[4]  Adrián M.T. Silva,et al.  Occurrence and removal of organic micropollutants: An overview of the watch list of EU Decision 2015/495. , 2016, Water research.

[5]  Gang Yu,et al.  Addressing the environmental risk of persistent organic pollutants in China , 2012, Frontiers of Environmental Science & Engineering.

[6]  Haiqun Cao,et al.  The occurrence and distribution of antibiotics in Lake Chaohu, China: seasonal variation, potential source and risk assessment. , 2015, Chemosphere.

[7]  K. Carlson,et al.  Quantification of human and veterinary antibiotics in water and sediment using SPE/LC/MS/MS , 2007, Analytical and bioanalytical chemistry.

[8]  Z. Qiu,et al.  Pharmaceutical and personal care products in the surface water of China: A review , 2014 .

[9]  C. Feng,et al.  Prevalence of Veterinary Antibiotics and Antibiotic-Resistant Escherichia coli in the Surface Water of a Livestock Production Region in Northern China , 2014, PloS one.

[10]  D. Barceló,et al.  Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. , 2006, Talanta.

[11]  Klaus Kümmerer,et al.  Antibiotics in the aquatic environment--a review--part I. , 2009, Chemosphere.

[12]  G. Lu,et al.  Occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants. , 2015, The Science of the total environment.

[13]  Wei Wu,et al.  Occurrence, seasonal variation and risk assessment of antibiotics in the reservoirs in North China. , 2014, Chemosphere.

[14]  Yaqi Cai,et al.  Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China. , 2012, Chemosphere.

[15]  Qian-Qian Zhang,et al.  Evaluation of triclosan and triclocarban at river basin scale using monitoring and modeling tools: implications for controlling of urban domestic sewage discharge. , 2013, Water research.

[16]  Jun Huang,et al.  Removal of pharmaceutical and personal care products by sequential ultraviolet and ozonation process in a full-scale wastewater treatment plant , 2014, Frontiers of Environmental Science & Engineering.

[17]  Daqiang Yin,et al.  Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China. , 2011, Chemosphere.

[18]  Liang Wang,et al.  Seasonal variation and sediment-water exchange of antibiotics in a shallower large lake in North China. , 2014, The Science of the total environment.

[19]  J. Wong,et al.  Preliminary occurrence studies of antibiotic residues in Hong Kong and Pearl River Delta , 2012, Environmental Monitoring and Assessment.

[20]  Gang Yu,et al.  Pharmaceuticals and consumer products in four wastewater treatment plants in urban and suburb areas of Shanghai , 2015, Environmental Science and Pollution Research.

[21]  Min Liu,et al.  Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment. , 2013, Environmental pollution.

[22]  Zongshan Zhao,et al.  Occurrences and distribution of sulfonamide and tetracycline resistance genes in the Yangtze River Estuary and nearby coastal area. , 2015, Marine pollution bulletin.

[23]  Qiuxin Huang,et al.  Chiral profiling of azole antifungals in municipal wastewater and recipient rivers of the Pearl River Delta, China , 2013, Environmental Science and Pollution Research.

[24]  Jian Xu,et al.  Distribution and ecological risk of antibiotics in a typical effluent-receiving river (Wangyang River) in north China. , 2014, Chemosphere.

[25]  Changzhou Yan,et al.  Occurrence, distribution, and seasonal variation of estrogenic compounds and antibiotic residues in Jiulongjiang River, South China , 2012, Environmental Science and Pollution Research.

[26]  Jiajun Hong,et al.  Simultaneous determination of 32 antibiotics and 12 pesticides in sediment using ultrasonic-assisted extraction and high performance liquid chromatography-tandem mass spectrometry , 2015 .

[27]  Yanbin Tong,et al.  Concentration and distribution of antibiotics in water–sediment system of Bosten Lake, Xinjiang , 2015, Environmental Science and Pollution Research.

[28]  Hanchang Shi,et al.  Occurrence and fate of antibiotics in advanced wastewater treatment facilities and receiving rivers in Beijing, China , 2014, Frontiers of Environmental Science & Engineering.

[29]  K. Chen,et al.  Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China. , 2014, Chemosphere.

[30]  Li Wang,et al.  Occurrence and risks of triclosan and triclocarban in the Pearl River system, South China: from source to the receiving environment. , 2010, Journal of hazardous materials.

[31]  C. Rice,et al.  Occurrence of antibiotics and hormones in a major agricultural watershed , 2008 .

[32]  Xin Yang,et al.  Occurrence and fate of PPCPs and correlations with water quality parameters in urban riverine waters of the Pearl River Delta, South China , 2013, Environmental Science and Pollution Research.

[33]  Jiamo Fu,et al.  Enantiomeric composition of polycyclic musks in sediments from the Pearl River and Suzhou Creek , 2015, Environmental Science and Pollution Research.

[34]  Yalei Zhang,et al.  Selective trace enrichment of acidic pharmaceuticals in real water and sediment samples based on solid-phase extraction using multi-templates molecularly imprinted polymers. , 2013, Analytica chimica acta.

[35]  Yaqi Cai,et al.  Occurrence, distribution, and bioaccumulation of antibiotics in coastal environment of Dalian, China. , 2013, Marine pollution bulletin.

[36]  R. Surampalli,et al.  A preliminary study on the occurrence and behavior of carbamazepine (CBZ) in aquatic environment of Yangtze River Delta, China , 2011, Environmental monitoring and assessment.

[37]  Gangfeng Ouyang,et al.  Determination of eight pharmaceuticals in an aqueous sample using automated derivatization solid-phase microextraction combined with gas chromatography-mass spectrometry. , 2015, Talanta.

[38]  Qixing Zhou,et al.  Occurrence, accumulation, attenuation and priority of typical antibiotics in sediments based on long-term field and modeling studies. , 2012, Journal of hazardous materials.

[39]  Jun Huang,et al.  Characterization of pharmaceutically active compounds in Beijing, China: Occurrence pattern, spatiotemporal distribution and its environmental implication. , 2017, Journal of hazardous materials.

[40]  G. Lu,et al.  Contamination by metals and pharmaceuticals in northern Taihu Lake (China) and its relation to integrated biomarker response in fish , 2012, Ecotoxicology.

[41]  Qixing Zhou,et al.  Trends in antibiotic resistance genes occurrence in the Haihe River, China. , 2010, Environmental science & technology.

[42]  Ding Wang,et al.  Occurrence of pharmaceuticals and personal care products and associated environmental risks in the central and lower Yangtze river, China. , 2014, Ecotoxicology and environmental safety.

[43]  Yan-xin Wang,et al.  Occurrence of antibiotics in the aquatic environment of Jianghan Plain, central China. , 2014, The Science of the total environment.

[44]  Jun Huang,et al.  Estimating the use of antibiotics for humans across China. , 2016, Chemosphere.

[45]  Gan Zhang,et al.  Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: occurrence, distribution and ecological risks. , 2013, Environmental pollution.

[46]  Fenglin Yang,et al.  Fate of antibiotics during wastewater treatment and antibiotic distribution in the effluent-receiving waters of the Yellow Sea, northern China. , 2013, Marine pollution bulletin.

[47]  Jun Yu Li,et al.  Antibiotic contamination in a typical developing city in south China: occurrence and ecological risks in the Yongjiang River impacted by tributary discharge and anthropogenic activities. , 2013, Ecotoxicology and environmental safety.

[48]  W. Meng,et al.  Occurrence, distribution and bioaccumulation of antibiotics in the Liao River Basin in China. , 2014, Environmental science. Processes & impacts.

[49]  O. Thomas,et al.  Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. , 2009, Environment international.

[50]  P. Anderson,et al.  Human pharmaceuticals in US surface waters: a human health risk assessment. , 2005, Regulatory toxicology and pharmacology : RTP.

[51]  Erik Kristiansson,et al.  Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. , 2008, Environmental science & technology.

[52]  G. Ying,et al.  Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography–tandem mass spectrometry , 2012, Analytical and Bioanalytical Chemistry.

[53]  J. Zhou,et al.  Application of passive sampling in assessing the occurrence and risk of antibiotics and endocrine disrupting chemicals in the Yangtze Estuary, China. , 2014, Chemosphere.

[54]  W. Meng,et al.  Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China. , 2014, The Science of the total environment.

[55]  C. Schüth,et al.  Occurrence and distribution of organic trace substances in waters from the Three Gorges Reservoir, China , 2013, Environmental Science and Pollution Research.

[56]  Chenguang Bao,et al.  Fate of sulfonamide resistance genes in estuary environment and effect of anthropogenic activities. , 2015, The Science of the total environment.

[57]  Jun Huang,et al.  Linking the environmental loads to the fate of PPCPs in Beijing: Considering both the treated and untreated wastewater sources. , 2015, Environmental pollution.

[58]  V. Andreu,et al.  Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain). , 2012, The Science of the total environment.

[59]  Xiang-dong Li,et al.  The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China. , 2013, Chemosphere.

[60]  Jun Huang,et al.  Pharmaceuticals and personal care products (PPCPs) in urban and suburban rivers of Beijing, China: occurrence, source apportionment and potential ecological risk. , 2016, Environmental science. Processes & impacts.

[61]  Saichang Zhu,et al.  Sources, distribution and potential risks of pharmaceuticals and personal care products in Qingshan Lake basin, Eastern China. , 2013, Ecotoxicology and environmental safety.

[62]  Jun Yu Li,et al.  Occurrence and risks of antibiotics in the coastal aquatic environment of the Yellow Sea, North China. , 2013, The Science of the total environment.

[63]  Min Lv,et al.  Pharmaceuticals and personal care products in a mesoscale subtropical watershed and their application as sewage markers. , 2014, Journal of hazardous materials.

[64]  P. Alvarez,et al.  Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China. , 2011, Environmental science & technology.

[65]  Y. Zhang,et al.  Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by liquid chromatography-tandem mass spectrometry , 2014, Frontiers of Environmental Science & Engineering.

[66]  G. Ying,et al.  Triclosan as a surrogate for household biocides: an investigation into biocides in aquatic environments of a highly urbanized region. , 2014, Water research.

[67]  John L. Zhou,et al.  Sediment-water interactions of pharmaceutical residues in the river environment. , 2014, Water research.

[68]  Xin Qian,et al.  Occurrence and behavior of pharmaceuticals in sewage treatment plants in eastern China , 2015, Frontiers of Environmental Science & Engineering.

[70]  Min Liu,et al.  Occurrence and distribution of antibiotics in the surface sediments of the Yangtze Estuary and nearby coastal areas. , 2014, Marine pollution bulletin.

[71]  Gang Yu,et al.  Characterization of pharmaceutically active compounds in Dongting Lake, China: Occurrence, chiral profiling and environmental risk. , 2016, The Science of the total environment.

[72]  E. Zeng,et al.  Occurrence and human health risk of wastewater-derived pharmaceuticals in a drinking water source for Shanghai, East China. , 2014, The Science of the total environment.

[73]  J. Zhou,et al.  Occurrence and phase distribution of selected pharmaceuticals in the Yangtze Estuary and its coastal zone. , 2011, Journal of hazardous materials.

[74]  B. Moodley,et al.  Pharmaceutical residues in water and sediment of Msunduzi River, KwaZulu-Natal, South Africa. , 2015, Chemosphere.

[75]  M. Wong,et al.  Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. , 2013, Environment international.

[76]  You-Peng Chen,et al.  Occurrence, fate and ecotoxicological assessment of pharmaceutically active compounds in wastewater and sludge from wastewater treatment plants in Chongqing, the Three Gorges Reservoir Area. , 2014, The Science of the total environment.

[77]  Gan Zhang,et al.  Antibiotics in riverine runoff of the Pearl River Delta and Pearl River Estuary, China: concentrations, mass loading and ecological risks. , 2013, Environmental pollution.

[78]  T. Ternes,et al.  Pharmaceuticals and personal care products in the environment: agents of subtle change? , 1999, Environmental health perspectives.

[79]  Gang Yu,et al.  Pharmaceuticals and personal care products in the aquatic environment in China: a review. , 2013, Journal of hazardous materials.

[80]  Jun Huang,et al.  Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in different biological wastewater treatment processes. , 2011, Environmental science & technology.

[81]  Other Directive 2000/60/EC of the European Parliament and of The Council of 23 October 2000 establishing a Framework for Community Action in the Field of Water Policy (Water Framework Directive) , 2000 .

[82]  Guangming Zhang,et al.  Emerging contaminants in surface waters in China—a short review , 2014 .

[83]  Bin Wang,et al.  Occurrence and source apportionment of pharmaceuticals and personal care products in the Beiyun River of Beijing, China. , 2015, Chemosphere.

[84]  T. Yuan,et al.  Determination of cephalosporin antibiotics in water samples by optimised solid phase extraction and high performance liquid chromatography with ultraviolet detector , 2011 .

[85]  Damià Barceló,et al.  Triclosan persistence through wastewater treatment plants and its potential toxic effects on river biofilms. , 2010, Aquatic toxicology.

[86]  Thomas Backhaus,et al.  Predictive environmental risk assessment of chemical mixtures: a conceptual framework. , 2012, Environmental science & technology.