Applications of synchrotron microtomography in osteoporosis research

Synchrotron microtomography enables us to visualize trabecular bone microarchitecture in 3D with a spatial resolution of a few microns. With recent developments in finite element modeling, it is possible to incorporate these images voxel by voxel into a finite-element model of the elastic properties of the bone. The ability to calculate mechanical behavior from 3D images will help us to understand the relationships between bone structure and properties.

[1]  John H. Kinney,et al.  DEFORMATION AND FAILURE IN CELLULAR MATERIALS , 1997 .

[2]  M. C. Nichols,et al.  X-Ray Tomographic Microscopy (XTM) Using Synchrotron Radiation , 1992 .

[3]  D. Burr,et al.  Bone Microdamage and Skeletal Fragility in Osteoporotic and Stress Fractures , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  J. Kinney,et al.  In vivo, three‐dimensional microscopy of trabecular bone , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  R. Recker.  Low Bone Mass May Not Be the Only Cause of Skeletal Fragility in Osteoporosis , 1989, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[6]  J. Kinney,et al.  Intermittent treatment with human parathyroid hormone (hPTH[1‐34]) increased trabecular bone volume but not connectivity in osteopenic rats , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  John H. Kinney,et al.  Elastic constants of cellular structures , 1997 .

[8]  C. Slemenda,et al.  Age and bone mass as predictors of fracture in a prospective study. , 1988, The Journal of clinical investigation.