Pediatric Vascular Anomalies: A Clinical and Radiological Perspective

Abstract According to the International Society for the Study of Vascular Anomalies (ISSVA) classification, vascular anomalies include a diverse range of pathologies, classified as either vascular tumors or vascular malformations. This classification, last revised in 2018, aims to explain the biological basis of vascular lesions and help clinicians to manage the anomalies. In vascular tumors, there are proliferative changes of endothelial cells, while vascular malformations primarily consist of structural vascular abnormalities. Infantile hemangioma is the most common soft-tissue vascular tumor. Vascular malformations are an extensive group of malformations of the arterial, venous, and lymphatic systems, either in isolation or in combination. Radiological evaluation plays a key part in the management of pediatric patients with these entities. The understanding of sonography and magnetic resonance imaging findings entails its correlation with clinical findings at the time of scanning.

[1]  M. Jinnin,et al.  ISSVA Classification of Vascular Anomalies and Molecular Biology , 2022, International journal of molecular sciences.

[2]  M. Carcao,et al.  Sirolimus Leads to Rapid Improvement in Fibroadipose Vascular Anomalies , 2021, Journal of Vascular Anomalies.

[3]  D. Song,et al.  Refractory Head and Neck Lymphatic Malformation in Infants Treated With Sirolimus: A Case Series , 2021, Frontiers in Oncology.

[4]  P. Garg,et al.  Fibro Adipose Vascular Anomaly: A Rare and Often Misdiagnosed Entity , 2021, Indian Journal of Radiology and Imaging.

[5]  M. Wassef,et al.  [Classification of vascular tumours and vascular malformations. Contribution of the ISSVA 2014/2018 classification]. , 2020, Annales de pathologie.

[6]  A. Barnacle,et al.  Vascular anomalies: special considerations in children , 2020, CVIR Endovascular.

[7]  H. Guimarães,et al.  Arteriovenous malformations in the neonatal period: case report and literature review , 2020 .

[8]  P. John Klippel-Trenaunay Syndrome. , 2019, Techniques in vascular and interventional radiology.

[9]  C. Hawkins,et al.  Diagnosis and Management of Extracranial Vascular Malformations in Children: Arteriovenous Malformations, Venous Malformations, and Lymphatic Malformations. , 2019, Seminars in roentgenology.

[10]  Jia-wei Zheng,et al.  Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas , 2018, Front. Oncol..

[11]  D. Shatzkes Vascular anomalies: Description, classification and nomenclature , 2018, Applied Radiology.

[12]  Trusha P Gajjar,et al.  Efficacy and safety of propranolol on the proliferative phase of infantile hemangioma: A hospital-based prospective study , 2018 .

[13]  M. Wildgruber,et al.  Vascular Anomalies (Part I): Classification and Diagnostics of Vascular Anomalies , 2018, RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.

[14]  B. Gontijo,et al.  PHACE syndrome: clinical manifestations, diagnostic criteria, and management* , 2018, Anais brasileiros de dermatologia.

[15]  Yi Ji,et al.  Intolerable side effects during propranolol therapy for infantile hemangioma: frequency, risk factors and management , 2018, Scientific Reports.

[16]  O. Navarro,et al.  Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations , 2017, Pediatric Radiology.

[17]  O. Navarro,et al.  Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 1: classification, sonographic approach and vascular tumors , 2017, Pediatric Radiology.

[18]  Christine Léauté-Labrèze,et al.  Infantile haemangioma , 2017, The Lancet.

[19]  C. Chambers,et al.  Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment , 2017, Birth defects research.

[20]  M. Reddick,et al.  Peripheral arteriovenous malformations: Classification and endovascular treatment , 2017, Applied Radiology.

[21]  A. Martínez-López,et al.  CLOVES syndrome: review of a PIK3CA‐related overgrowth spectrum (PROS) , 2017, Clinical genetics.

[22]  Anita Gupta,et al.  2014 Revised Classification of Vascular Lesions from the International Society for the Study of Vascular Anomalies: Radiologic-Pathologic Update. , 2016, Radiographics : a review publication of the Radiological Society of North America, Inc.

[23]  Hoon-Chul Kang,et al.  Clinical and Genetic Aspects of the Segmental Overgrowth Spectrum Due to Somatic Mutations in PIK3CA. , 2015, The Journal of pediatrics.

[24]  M. Vikkula,et al.  Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies , 2015, Pediatrics.

[25]  R. Azizkhan,et al.  Hepatic vascular tumors. , 2014, Seminars in pediatric surgery.

[26]  S. Fishman,et al.  Management of visceral vascular anomalies. , 2014, Seminars in pediatric surgery.

[27]  M. Vikkula,et al.  Genetics of vascular malformations. , 2014, Seminars in pediatric surgery.

[28]  I. Frieden,et al.  Infantile and congenital hemangiomas. , 2014, Seminars in pediatric surgery.

[29]  R. Elluru,et al.  Lymphatic malformations: diagnosis and management. , 2014, Seminars in pediatric surgery.

[30]  S. Fishman,et al.  Overgrowth syndromes with complex vascular anomalies. , 2014, Seminars in pediatric surgery.

[31]  J. Mulliken,et al.  Safety and Efficacy of Bleomycin Sclerotherapy for Microcystic Lymphatic Malformation , 2014, CardioVascular and Interventional Radiology.

[32]  W. Chung,et al.  RASA1 Mutations and Associated Phenotypes in 68 Families with Capillary Malformation–Arteriovenous Malformation , 2013, Human mutation.

[33]  P. Meyers,et al.  Congenital Cutaneous Hemangioma Causing Cardiac Failure: A Case Report and Review of the Literature , 2013, Pediatric dermatology.

[34]  M. Vikkula,et al.  Variable Somatic TIE2 Mutations in Half of Sporadic Venous Malformations , 2013, Molecular Syndromology.

[35]  Yi Ji,et al.  Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells. , 2012, Journal of pediatric surgery.

[36]  J. Mulliken,et al.  PTEN Hamartoma of Soft Tissue: A Distinctive Lesion in PTEN Syndromes , 2012, The American journal of surgical pathology.

[37]  D. Rivard,et al.  Vascular malformations: classification and terminology the radiologist needs to know. , 2012, Seminars in roentgenology.

[38]  J. Beaumont,et al.  Measuring the severity of infantile hemangiomas: instrument development and reliability. , 2012, Archives of dermatology.

[39]  S. Janmohamed,et al.  Treatment of Small Superficial Haemangioma with Timolol 0.5% Ophthalmic Solution: A Series of 20 Cases , 2011, Dermatology.

[40]  W. Hop,et al.  Scoring the proliferative activity of haemangioma of infancy: the Haemangioma Activity Score (HAS) , 2011, Clinical and experimental dermatology.

[41]  G. Chaudry,et al.  Sclerotherapy of abdominal lymphatic malformations with doxycycline. , 2011, Journal of vascular and interventional radiology : JVIR.

[42]  R. Silverman,et al.  LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. , 2010, The Journal of pediatrics.

[43]  K. Holland,et al.  Risk for PHACE Syndrome in Infants With Large Facial Hemangiomas , 2010, Pediatrics.

[44]  Hidenori Sugano,et al.  [Sturge-Weber syndrome]. , 2010, No shinkei geka. Neurological surgery.

[45]  Iris Gutmark-Little,et al.  Pediatric , 2010, Bone Marrow Transplantation.

[46]  Gerald Legiehn1,et al.  A Step-by-Step Practical Approach to Imaging Diagnosis and Interventional Radiologic Therapy in Vascular Malformations , 2010 .

[47]  G. Legiehn,et al.  A Step-by-Step Practical Approach to Imaging Diagnosis and Interventional Radiologic Therapy in Vascular Malformations , 2010, Seminars in interventional radiology.

[48]  C. Hess,et al.  Consensus Statement on Diagnostic Criteria for PHACE Syndrome , 2009, Pediatrics.

[49]  F. Martines,et al.  Arteriovenous malformation of the base of tongue in pregnancy: case report. , 2009, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.

[50]  D. Adams,et al.  Infantile hemangiomas with unusually prolonged growth phase: a case series. , 2008, Archives of dermatology.

[51]  D. Cooke,et al.  Imaging and Percutaneous Treatment of Vascular Anomalies , 2008, Seminars in interventional radiology.

[52]  F. Boralevi,et al.  Propranolol for severe hemangiomas of infancy. , 2008, The New England journal of medicine.

[53]  I. Frieden,et al.  Vascular malformations: Part I. , 2007, Journal of the American Academy of Dermatology.

[54]  F. Boralevi,et al.  SACRAL Syndrome: Spinal Dysraphism, Anogenital, Cutaneous, Renal and Urologic Anomalies, Associated with an Angioma of Lumbosacral Localization , 2006, Dermatology.

[55]  G. Legiehn,et al.  Classification, diagnosis, and interventional radiologic management of vascular malformations. , 2006, The Orthopedic clinics of North America.

[56]  M. Garzón,et al.  A prospective study of PHACE syndrome in infantile hemangiomas: Demographic features, clinical findings, and complications , 2006, American journal of medical genetics. Part A.

[57]  H. Chan,et al.  Comparison study of a traditional pulsed dye laser versus a long‐pulsed dye laser in the treatment of early childhood hemangiomas , 2006, Lasers in surgery and medicine.

[58]  A. Krol,et al.  Congenital hemangiomas: rapidly involuting and noninvoluting congenital hemangiomas. , 2005, Archives of facial plastic surgery.

[59]  J. Mulliken,et al.  Rapidly Involuting Congenital Hemangioma: Clinical and Histopathologic Features , 2003, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[60]  A. Fleischer,et al.  Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. , 2001, Archives of dermatology.

[61]  J. Mulliken,et al.  Soft-tissue vascular anomalies: utility of US for diagnosis. , 2000, Radiology.

[62]  L. Garel,et al.  Soft-tissue venous malformations in pediatric and young adult patients: diagnosis with Doppler US. , 1999, Radiology.

[63]  L. Garel,et al.  Soft-tissue hemangiomas in infants and children: diagnosis using Doppler sonography. , 1998, AJR. American journal of roentgenology.

[64]  R. Geronemus,et al.  Guidelines of care for hemangiomas of infancy , 1997 .

[65]  K. Sie,et al.  Lymphatic malformations of the head and neck. A proposal for staging. , 1995, Archives of otolaryngology--head & neck surgery.

[66]  J. Glowacki,et al.  Hemangiomas and Vascular Malformations in Infants and Children: A Classification Based on Endothelial Characteristics , 1982, Plastic and reconstructive surgery.

[67]  L. Fayad,et al.  International Society for the Study of Vascular Anomalies Classification of Soft Tissue Vascular Anomalies: Survey-Based Assessment of Musculoskeletal Radiologists' Use in Clinical Practice. , 2019, Current problems in diagnostic radiology.

[68]  G. Richter,et al.  Arteriovenous malformations. , 2014, Seminars in pediatric surgery.

[69]  Manish N. Patel,et al.  Venous malformations. , 2014, Seminars in pediatric surgery.

[70]  D. Siegel,et al.  Propranolol Treatment of Infantile Hemangiomas: Anticipatory Guidance for Parents and Caretakers , 2013, Pediatric dermatology.

[71]  B. Guillot,et al.  PELVIS Syndrome. , 2006, Archives of dermatology.