Cerebrospinal fluid transthyretin in the neonate and blood–cerebrospinal fluid barrier permeability

We measured transthyretin levels in the cerebrospinal fluid (CSF) of newborn infants, older children, patients with viral and bacterial meningitis, and adults with increased CSF protein levels. Neonatal CSF transthyretin levels are elevated disproportionately in comparison to levels in the other groups. We conclude that increased levels of transthyretin in the CSF of neonates are not explained by increased permeability of the blood–CSF barrier.

[1]  M. Albert,et al.  Physostigmine‐induced myoclonus in Alzheimer's disease , 1987, Neurology.

[2]  T. Padma,et al.  Haptoglobin patterns in essential hypertension and associated conditions--increased risk for Hp 2-2. , 1987, Human heredity.

[3]  P. Dickson,et al.  Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that in liver. , 1986, The Journal of biological chemistry.

[4]  N. Bhat,et al.  Cell proliferation in growing cultures of dissociated embryonic mouse brain: macromolecule and ornithine decarboxylase synthesis and regulation by hormones and drugs , 1983, Journal of neuroscience research.

[5]  B. Weisner,et al.  The concentration of prealbumin in cerebrospinal fluid (CSF), indicator of CSF circulation disorders. , 1983, European neurology.

[6]  M. Adinolfi,et al.  Levels of Plasma Proteins in Human and Rat Fetal CSF and the Development of the Blood-CSF Barrier , 1977, Neuropadiatrie.

[7]  S. Ohman,et al.  Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. , 1977, Scandinavian journal of clinical and laboratory investigation.

[8]  K. Felgenhauer,et al.  Evaluation of the blood-CSF barrier by protein gradients and the humoral immune response within the central nervous system , 1976, Journal of the Neurological Sciences.

[9]  O. Amtorp,et al.  The ontogenetic development of concentration differences for protein and ions between plasma and cerebrospinal fluid in rabbits and rats , 1974, The Journal of physiology.

[10]  P. Lundborg,et al.  Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: clearance of carboxyl-( 14 C)inulin after intrathecal infusion. , 1973, Brain research.

[11]  Y. Muto,et al.  Vitamin A transport in rat plasma. Isolation and characterization or retinol-binding protein. , 1972, The Journal of biological chemistry.

[12]  J. Oppenheimer.  Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones. , 1968, The New England journal of medicine.