Macrophage migration inhibitory factor in the sera and at the colonic mucosa in patients with ulcerative colitis: clinical implications and pathogenic significance

Background Inflammatory cytokines produced by activated macrophages are implicated in the pathogenesis of ulcerative colitis (UC). With the theory that macrophage migration inhibitory factor (MIF) may have a role in the accumulation of macrophages, we studied MIF in UC.

[1]  R. Atkins,et al.  Expression of macrophage migration inhibitory factor in human glomerulonephritis. , 2000, Kidney international.

[2]  R. Abe,et al.  Increased production of macrophage migration inhibitory factor by PBMCs of atopic dermatitis. , 1999, The Journal of allergy and clinical immunology.

[3]  R. Bucala,et al.  Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. , 1999, Arthritis and rheumatism.

[4]  H. Koeppen,et al.  An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease. , 1998, Gastroenterology.

[5]  R. Bucala,et al.  Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. , 1997, Molecular medicine today.

[6]  R. Holmdahl,et al.  Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice. , 1997, Journal of immunology.

[7]  J. Bernhagen,et al.  The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor , 1994, The Journal of experimental medicine.

[8]  C. Nast,et al.  Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis. , 1992, Gastroenterology.

[9]  Y. Mahida,et al.  Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease. , 1989, Gut.

[10]  P. Whorwell,et al.  Immunological aspects of inflammatory bowel disease. , 1976, Clinics in gastroenterology.

[11]  J. David.  Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[12]  B. Bloom,et al.  Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity , 1966, Science.

[13]  N. Horiike,et al.  Absence of CD83-positive mature and activated dendritic cells at cancer nodules from patients with hepatocellular carcinoma: relevance to hepatocarcinogenesis. , 2000, Cancer letters.

[14]  M. Onji,et al.  Immunohistochemical localization of antigen presenting cells in liver from patients with primary biliary cirrhosis; highly restricted distribution of CD83-positive activated dendritic cells. , 1999, Pathology, research and practice.

[15]  K. Namba,et al.  Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis. , 1999, Investigative ophthalmology & visual science.

[16]  S G MATTS,et al.  The value of rectal biopsy in the diagnosis of ulcerative colitis. , 1961, The Quarterly journal of medicine.