Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

John P. Rice | Warren W. Kretzschmar | Robert M. Maier | P. O’Reilly | P. Visscher | N. Wray | A. Uitterlinden | I. Deary | E. Mihailov | J. Marchini | H. Stefánsson | S. Cichon | S. Steinberg | E. Sigurdsson | T. Thorgeirsson | M. Rietschel | T. Werge | M. Nöthen | K. Stefánsson | J. Potash | T. Schulze | M. Gill | N. Craddock | M. Owen | P. Sullivan | K. Tansey | Jianxin Shi | Z. Kutalik | M. Weissman | G. Breen | P. McGuffin | C. Lewis | I. Kohane | H. Völzke | Yunpeng Wang | S. Mostafavi | W. Maier | J. Smoller | N. Martin | G. Crawford | A. McIntosh | M. Preisig | V. Arolt | G. Willemsen | B. Penninx | A. Metspalu | T. Esko | G. Montgomery | L. Milani | D. Blackwood | J. Knowles | D. Mehta | J. Wellmann | U. Dannlowski | B. Baune | K. Kendler | D. Posthuma | D. Boomsma | R. Perlis | D. Porteous | D. Levinson | S. Paciga | D. Nyholt | J. Hottenga | N. Pedersen | J. Smit | G. Lewis | K. Domschke | H. Gaspar | S. Bacanu | A. Heath | O. Mors | R. Uher | E. Derks | M. O’Donovan | P. Mortensen | A. Børglum | M. Nordentoft | D. Hougaard | M. Mattheisen | H. Grabe | G. Homuth | A. Teumer | S. Medland | B. Müller-Myhsok | J. Bryois | S. Ripke | Qingqin S. Li | H. Xi | A. Abdellaoui | D. Umbricht | B. Riley | S. Hamilton | G. Davies | Jian Yang | H. Tiemeier | C. Hayward | P. Lind | W. Peyrot | K. Berger | P. Madden | Danny J. Smith | B. Webb | Y. Milaneschi | T. Andlauer | C. Schaefer | E. Domenici | E. Binder | F. Goes | C. Dolan | R. Schoevers | H. Finucane | B. Couvy-Duchesne | M. Nauck | A. Henders | P. Hoffmann | S. Gordon | E. D. Geus | Yang Wu | H. Mbarek | R. Jansen | C. Middeldorp | R. Maier | E. Agerbo | J. Bybjerg-Grauholm | M. Bækvad-Hansen | C. Hansen | C. Pedersen | M. Pedersen | V. Escott-Price | L. Hall | E. Byrne | T. Eley | J. Painter | L. Colodro-Conde | S. Witt | F. Degenhardt | A. Forstner | S. Herms | Futao Zhang | A. Beekman | J. Coleman | E. Jorgenson | H. Fisher | M. Adams | D. Macintyre | N. Mullins | G. Pistis | P. Thomson | H. Teismann | D. MacKinnon | F. Mondimore | J. R. DePaulo | T. Bigdeli | T. Clarke | M. Nivard | L. Shen | J. Grove | J. Christensen | P. Qvist | F. Streit | J. Treutlein | M. Trzaskowski | J. Strohmaier | S. Lucae | H. Oskarsson | J. Frank | T. Hansen | M. Ising | Stanley I. Shyn | N. Direk | B. Ng | E. Dunn | G. Sinnamon | R. Peterson | P. McGrath | S. Kloiber | S. Mirza | T. Air | H. Buttenschøn | A. Viktorin | N. Cai | E. Castelao | Carsten Horn | J. Kraft | J. Krogh | Yihan Li | E. Pettersson | J. Quiroz | M. Rivera | E. Schulte | M. Traylor | V. Trubetskoy | S. Weinsheimer | P. Magnusson | Wesley Thompson | A. M. Hemert | N. G. Martin | W. Kretzschmar | N. Martin | Na Cai | S. Auwera | Andrew C. Heat | Tracy Air | Elliot N. Nelson | Farnush | Farhadi Hassan Kiadeh | Ian B. Hicki | N. Martin | B.W.J.H. Penninx | A. Uitterlinden | S. Gordon | D. Boomsma | Héléna A. Gaspar | Grant C. B. Sinnamon | N. Martin | Toni‐Kim Clarke | Roseann E. Peterson | N. Martin | Marie Bækvad-Hansen | N. Martin | C. Lewis

[1]  John P. Rice,et al.  GENOME-WIDE ASSOCIATION ANALYSES IDENTIFY 44 RISK VARIANTS AND REFINE THE GENETIC ARCHITECTURE OF MAJOR DEPRESSIVE DISORDER , 2019, European Neuropsychopharmacology.

[2]  L. Bierut,et al.  Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression , 2017, Molecular Psychiatry.

[3]  B. Baune,et al.  Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder – Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study) , 2016, Front. Psychiatry.

[4]  D. Hinds,et al.  Identification of 15 genetic loci associated with risk of major depression in individuals of European descent , 2016, Nature Genetics.

[5]  Jonathan P. Beauchamp,et al.  Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses , 2016, Nature Genetics.

[6]  A. Dehghan,et al.  Polygenic dissection of major depression clinical heterogeneity , 2016, Molecular Psychiatry.

[7]  N. Wray,et al.  Disease and Polygenic Architecture: Avoid Trio Design and Appropriately Account for Unscreened Control Subjects for Common Disease. , 2016, American journal of human genetics.

[8]  Klaus P. Ebmeier,et al.  Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS) , 2015, PloS one.

[9]  J. Potash,et al.  Polygenic interactions with environmental adversity in the aetiology of major depressive disorder , 2015, Psychological Medicine.

[10]  Frank Dudbridge,et al.  A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait. , 2015, American journal of human genetics.

[11]  C. Sabatti,et al.  Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort , 2015, Genetics.

[12]  Warren W. Kretzschmar,et al.  Sparse whole genome sequencing identifies two loci for major depressive disorder , 2015, Nature.

[13]  John P. Rice,et al.  The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects , 2015, Molecular Psychiatry.

[14]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[15]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[16]  S. Rosset,et al.  Measuring missing heritability: Inferring the contribution of common variants , 2014, Proceedings of the National Academy of Sciences.

[17]  Carson C Chow,et al.  Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.

[18]  Robert M. Maier,et al.  Genetic Basis of Complex Genetic Disease: The Contribution of Disease Heterogeneity to Missing Heritability , 2014, Current Epidemiology Reports.

[19]  J. Witte,et al.  The contribution of genetic variants to disease depends on the ruler , 2014, Nature Reviews Genetics.

[20]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[21]  P. Sullivan,et al.  Effect of polygenic risk scores on depression in childhood trauma , 2014, British Journal of Psychiatry.

[22]  Y. Milaneschi,et al.  The effect of FTO rs9939609 on major depression differs across MDD subtypes , 2014, Molecular Psychiatry.

[23]  Matthew C. Keller,et al.  Gene × Environment Interaction Studies Have Not Properly Controlled for Potential Confounders: The Problem and the (Simple) Solution , 2014, Biological Psychiatry.

[24]  Rui Mei,et al.  Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing , 2013, Molecular Psychiatry.

[25]  Jonathan J. Evans,et al.  Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants , 2013, PloS one.

[26]  L. Bierut,et al.  Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression , 2013, BMC Psychiatry.

[27]  Martin H. Teicher,et al.  Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. , 2013, The American journal of psychiatry.

[28]  Jianxin Shi,et al.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs , 2013, Nature Genetics.

[29]  Archie Campbell,et al.  Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. , 2013, International journal of epidemiology.

[30]  Patrick F. Sullivan,et al.  Genetic architectures of psychiatric disorders: the emerging picture and its implications , 2012, Nature Reviews Genetics.

[31]  P. Visscher,et al.  A Better Coefficient of Determination for Genetic Profile Analysis , 2012, Genetic epidemiology.

[32]  N. Martin,et al.  Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression. , 2012, Archives of general psychiatry.

[33]  R. Graaf,et al.  Prevalence of mental disorders and trends from 1996 to 2009. Results from the Netherlands Mental Health Survey and Incidence Study-2 , 2012, Social Psychiatry and Psychiatric Epidemiology.

[34]  Matthew C Keller,et al.  A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. , 2011, The American journal of psychiatry.

[35]  Manuel A. R. Ferreira,et al.  Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 , 2011, Nature Genetics.

[36]  K. Shedden,et al.  The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. , 2011, Archives of general psychiatry.

[37]  W. Rathmann,et al.  Cohort profile: the study of health in Pomerania. , 2011, International journal of epidemiology.

[38]  Allison L Miller,et al.  Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study , 2011, British Journal of Psychiatry.

[39]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[40]  N. Wray,et al.  Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned , 2010, Molecular Psychiatry.

[41]  D. Altshuler,et al.  A map of human genome variation from population-scale sequencing , 2010, Nature.

[42]  K. Kendler,et al.  Interpretation of interactions: guide for the perplexed. , 2010, The British journal of psychiatry : the journal of mental science.

[43]  P. Muglia,et al.  Genome-wide association study of major recurrent depression in the U.K. population. , 2010, The American journal of psychiatry.

[44]  N. Wray,et al.  Genetic risk profiles for depression and anxiety in adult and elderly cohorts , 2010, Molecular Psychiatry.

[45]  M. Munafo,et al.  Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis , 2010, Psychological Medicine.

[46]  F. Zitman,et al.  Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders vs. controls , 2009, Acta psychiatrica Scandinavica.

[47]  P. Visscher,et al.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.

[48]  N. Risch,et al.  Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. , 2009, JAMA.

[49]  M. Munafo,et al.  Gene × Environment Interactions at the Serotonin Transporter Locus , 2009, Biological Psychiatry.

[50]  P. Cuijpers,et al.  The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods , 2008, International journal of methods in psychiatric research.

[51]  D. Grobbee,et al.  Estimating interaction on an additive scale between continuous determinants in a logistic regression model. , 2007, International journal of epidemiology.

[52]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[53]  Patrick F. Sullivan,et al.  Spurious Genetic Associations , 2007, Biological Psychiatry.

[54]  Peter Kraft,et al.  Exploiting Gene-Environment Interaction to Detect Genetic Associations , 2007, Human Heredity.

[55]  Lindon J. Eaves,et al.  Genotype × Environment Interaction in Psychopathology: Fact or Artifact? , 2006, Twin Research and Human Genetics.

[56]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[57]  M. Newcomb,et al.  Development and validation of a brief screening version of the Childhood Trauma Questionnaire. , 2003, Child abuse & neglect.

[58]  Shaun Purcell,et al.  Variance components models for gene-environment interaction in twin analysis. , 2002, Twin research : the official journal of the International Society for Twin Studies.

[59]  D. Falconer The Problem of Environment and Selection , 1952, The American Naturalist.

[60]  Philip Spinhoven,et al.  Childhood Trauma Questionnaire: factor structure, measurement invariance, and validity across emotional disorders. , 2014, Psychological assessment.