Prevention of posttraumatic stress disorder.

Traumatic events are common, but the psychological distress that may follow usually subsides naturally. For some individuals, distress develops into posttraumatic stress disorder (PTSD). PTSD lends itself to the application of prevention strategies for at-risk individuals. The identification of a causal event may make prevention efforts for PTSD more feasible and effective than for other psychological disorders. For PTSD, these efforts target those traumatized persons who are beginning to exhibit symptoms of PTSD. These interventions could also target individuals meeting criteria for acute stress disorder with the goal of preventing chronic PTSD.

[1]  J. D. McGaugh,et al.  Memory for emotional events: differential effects of centrally versus peripherally acting β-blocking agents , 1998, Psychopharmacology.

[2]  J. D. McGaugh,et al.  Beta-adrenergic activation and memory for emotional events. , 1994, Nature.

[3]  B. Roozendaal,et al.  The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors , 2001, Biological Psychiatry.

[4]  James L. McGaugh,et al.  Stress and glucocorticoids impair retrieval of long-term spatial memory , 1998, Nature.

[5]  Joseph James Duffy,et al.  beta-Adrenergic blockade and emotional memory in PTSD. , 2001, The international journal of neuropsychopharmacology.

[6]  R. Pitman,et al.  Post-traumatic stress disorder, hormones, and memory , 1989, Biological Psychiatry.

[7]  B. Rothbaum,et al.  Uncontrollability and unpredictability in post-traumatic stress disorder: an animal model. , 1992, Psychological bulletin.

[8]  K. Felmingham,et al.  A randomized controlled trial of exposure therapy and cognitive restructuring for posttraumatic stress disorder. , 2008, Journal of consulting and clinical psychology.

[9]  J. Ruzek,et al.  Psychological First Aid , 2007, Journal of the Pakistan Medical Association.

[10]  W. Katon,et al.  A randomized effectiveness trial of stepped collaborative care for acutely injured trauma survivors. , 2004, Archives of general psychiatry.

[11]  B. Roozendaal,et al.  Can Posttraumatic Stress Disorder Be Prevented with Glucocorticoids? , 2004, Annals of the New York Academy of Sciences.

[12]  J. Yesavage,et al.  No improvement of posttraumatic stress disorder symptoms with guanfacine treatment. , 2006, The American journal of psychiatry.

[13]  R. Bryant.  Early predictors of posttraumatic stress disorder , 2003, Biological Psychiatry.

[14]  J. Lauriello,et al.  Imagery rehearsal therapy for chronic nightmares in sexual assault survivors with posttraumatic stress disorder: a randomized controlled trial. , 2001, JAMA.

[15]  R. Newcombe,et al.  Early cognitive–behavioural therapy for post-traumatic stress symptoms after physical injury , 2004, British Journal of Psychiatry.

[16]  Tracie O. Afifi,et al.  Physical and Mental Comorbidity, Disability, and Suicidal Behavior Associated With Posttraumatic Stress Disorder in a Large Community Sample , 2007, Psychosomatic medicine.

[17]  D. Silove,et al.  A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder , 2009, Biological Psychiatry.

[18]  Y. Gidron,et al.  Interactive Effects of Memory Structuring and Gender in Preventing Posttraumatic Stress Symptoms , 2007, The Journal of nervous and mental disease.

[19]  J. H. Curtis,et al.  Learning Theory and Behavior , 1960 .

[20]  P. Buckley.  Morphine Use after Combat Injury in Iraq and Post-Traumatic Stress Disorder , 2011 .

[21]  B. Roozendaal,et al.  Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study , 2004, Biological Psychiatry.

[22]  A. Leppävuori,et al.  Effects of methoxamine, and alpha-1 adrenoceptor agonist, and prazosin, an alpha-1 antagonist, on the stages of the sleep-waking cycle in the cat. , 1984, Acta physiologica Scandinavica.

[23]  G. Aston-Jones,et al.  Modulation of opiate responses in brain noradrenergic neurons by the cyclic AMP cascade: Changes with chronic morphine , 1993, Neuroscience.

[24]  J. Blass.  A Parallel Group Placebo Controlled Study of Prazosin for Trauma Nightmares and Sleep Disturbance in Combat Veterans with Post-Traumatic Stress Disorder , 2008 .

[25]  A. Harvey,et al.  Integration of psychological and biological approaches to trauma memory: implications for pharmacological prevention of PTSD. , 2004, Journal of traumatic stress.

[26]  Lynda A. King,et al.  Relationship between acute morphine and the course of PTSD in children with burns. , 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

[27]  J. H. Kamphuis,et al.  Post-trauma debriefing : the road too frequently travelled , 2022 .

[28]  J. Monti,et al.  Effects of methoxamine and alpha-adrenoceptor antagonists, prazosin and yohimbine, on the sleep-wake cycle of the rat. , 1984, Sleep.

[29]  Ø. Ekeberg,et al.  Early trauma-focused cognitive-behavioural therapy to prevent chronic post-traumatic stress disorder and related symptoms: A systematic review and meta-analysis , 2008, BMC psychiatry.

[30]  R. Yehuda,et al.  The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder , 2002, Biological Psychiatry.

[31]  Matt J. Gray,et al.  Acute Psychological Impact of Disaster and Large-Scale Trauma: Limitations of Traditional Interventions and Future Practice Recommendations , 2004, Prehospital and Disaster Medicine.

[32]  Jennifer E. Drake,et al.  Preliminary Evidence for the Effects of Morphine on Posttraumatic Stress Disorder Symptoms in One- to Four-Year-Olds With Burns , 2009, Journal of burn care & research : official publication of the American Burn Association.

[33]  R. Kessler,et al.  Posttraumatic stress disorder: the burden to the individual and to society. , 2000, The Journal of clinical psychiatry.

[34]  J. Bisson,et al.  Randomised controlled trial of psychological debriefing for victims of acute burn trauma , 1997, British Journal of Psychiatry.

[35]  M. Haller,et al.  The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors. , 1999, Critical care medicine.

[36]  M. Stein,et al.  Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients. , 2007, Journal of traumatic stress.

[37]  Patricia J. Mrazek,et al.  Reducing risks for mental disorders: Frontiers for preventive intervention research. , 1994 .

[38]  D. Weiss,et al.  Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. , 2003, Psychological bulletin.

[39]  Benno Roozendaal,et al.  Stress and Memory: Opposing Effects of Glucocorticoids on Memory Consolidation and Memory Retrieval , 2002, Neurobiology of Learning and Memory.

[40]  Y. Gidron,et al.  Translating Research Findings to PTSD Prevention: Results of a Randomized–Controlled Pilot Study , 2001, Journal of traumatic stress.

[41]  Chris R Brewin,et al.  Psychological theories of posttraumatic stress disorder. , 2003, Clinical psychology review.

[42]  Charles R. Figley.  Stress Response Syndromes, 2nd ed , 1987 .

[43]  C. Brewin,et al.  Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. , 2000, Journal of consulting and clinical psychology.

[44]  E. Ellis.  Treating the Trauma of Rape: Cognitive Behavioral Therapy for PTSD , 1999 .

[45]  Matt J. Gray,et al.  Early intervention for trauma: Current status and future directions. , 2006 .

[46]  M. Feldner,et al.  A Critical Analysis of Approaches to Targeted PTSD Prevention , 2007, Behavior modification.

[47]  J T Mitchell,et al.  When disaster strikes...the critical incident stress debriefing process. , 1983, JEMS : a journal of emergency medical services.

[48]  R. Kessler,et al.  Posttraumatic stress disorder in the National Comorbidity Survey. , 1995, Archives of general psychiatry.

[49]  D. Bolton,et al.  Mind, Meaning, And Mental Disorder , 1996 .

[50]  A. Harvey,et al.  A prospective study of psychophysiological arousal, acute stress disorder, and posttraumatic stress disorder. , 2000, Journal of abnormal psychology.

[51]  Robert Stickgold,et al.  Sleep promotes generalization of extinction of conditioned fear. , 2009, Sleep.

[52]  P. Resick,et al.  Cognitive processing therapy for sexual assault victims. , 1992, Journal of consulting and clinical psychology.

[53]  Bruce Nolan,et al.  REM sleep and the early development of posttraumatic stress disorder. , 2002, The American journal of psychiatry.

[54]  E. Peskind,et al.  Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. , 2003, The American journal of psychiatry.

[55]  T. Dalgleish,et al.  A dual representation theory of posttraumatic stress disorder. , 1996, Psychological review.

[56]  D. Delahanty,et al.  Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims. , 2003, Journal of anxiety disorders.

[57]  B. Bledsoe.  C RITICAL I NCIDENT S TRESS M ANAGEMENT (CISM): B ENEFIT OR R ISK FOR E MERGENCY S ERVICES ? , 2003, Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors.

[58]  L. Cahill,et al.  Pilot study of secondary prevention of posttraumatic stress disorder with propranolol , 2002, Biological Psychiatry.

[59]  R. Stickgold.  Of sleep, memories and trauma , 2007, Nature Neuroscience.

[60]  Charles R Marmar,et al.  Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. , 2007, The Journal of clinical psychiatry.

[61]  E. Peskind,et al.  Prazosin Effects on Objective Sleep Measures and Clinical Symptoms in Civilian Trauma Posttraumatic Stress Disorder: A Placebo-Controlled Study , 2008, Biological Psychiatry.

[62]  J. Fishman,et al.  Propranolol and the Prevention of Post-Traumatic Stress Disorder: Is it Wrong to Erase the “Sting” of Bad Memories? , 2007, American Journal of Bioethics.

[63]  David Lester,et al.  Post-Traumatic Stress Disorder and Suicide Risk: A Systematic Review , 2010, Archives of suicide research : official journal of the International Academy for Suicide Research.

[64]  G. Everly,et al.  Critical incident stress management -CISM- : a new era and standard of care in crisis intervention , 1999 .

[65]  R. Lubow,et al.  Latent inhibition: the effect of nonreinforced pre-exposure to the conditional stimulus. , 1959, Journal of comparative and physiological psychology.

[66]  M. Raskind.  Pharmacologic Treatment of PTSD , 2009 .

[67]  R. Sack,et al.  The polysomnographic effects of clonidine on sleep disorders in posttraumatic stress disorder: a pilot study with Cambodian patients. , 1994, The Journal of nervous and mental disease.

[68]  M. Stein,et al.  Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorder , 2007, Psychological Medicine.

[69]  M. Haller,et al.  Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. , 1999, Critical care medicine.

[70]  S. Orr,et al.  A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder. , 1998, Archives of general psychiatry.

[71]  G. Asnis,et al.  Sleep Disturbances in Patients with Post-Traumatic Stress Disorder , 2006, CNS drugs.

[72]  M. Horowitz.  Stress response syndromes , 1976 .

[73]  M. Kozak,et al.  Emotional processing of fear: exposure to corrective information. , 1986, Psychological bulletin.

[74]  George M. Realmuto,et al.  Shattered Assumptions: Towards a New Psychology of Trauma , 1994 .

[75]  Janet B W Williams.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[76]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.