Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo

A cell-free system using cytoplasmic extract from single–Drosophila syncytial embryos reveals that the spacing between nuclei is preprogrammed and relies on microtubule aster migration.

[1]  A. Hyman,et al.  Spindle positioning by cortical pulling forces. , 2005, Developmental cell.

[2]  K. Sander,et al.  Embryogenesis of the honeybee apis mellifera l. (hymenoptera : apidae): An sem study , 1986 .

[3]  B. Alberts,et al.  Behaviour of microtubules and actin filaments in living Drosophila embryos. , 1988, Development.

[4]  Y. Hiramoto,et al.  Analysis of the Role of Astral Rays in Pronuclear Migration in Sand Dollar Eggs by the Colcemid‐UV Method , 1986, Development, growth & differentiation.

[5]  M. Glotzer,et al.  The 3Ms of central spindle assembly: microtubules, motors and MAPs , 2009, Nature Reviews Molecular Cell Biology.

[6]  E. Cupp,et al.  Early embryology of Aedes aegypti (L.) (Diptera: Culicidae) , 1975 .

[7]  J. Raff,et al.  Drosophila Spd-2 Recruits PCM to the Sperm Centriole, but Is Dispensable for Centriole Duplication , 2007, Current Biology.

[8]  X. Morin,et al.  A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[9]  B. Alberts,et al.  Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis. , 1983, Journal of cell science.

[10]  T. Kaufman,et al.  The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. , 1999, Development.

[11]  P. Gönczy,et al.  Mechanisms of nuclear positioning. , 1998, Journal of cell science.

[12]  J. Raff,et al.  Centrosomes, and not nuclei, initiate pole cell formation in Drosophila embryos , 1989, Cell.

[13]  J. Raff,et al.  Flies without Centrioles , 2006, Cell.

[14]  P. Lénárt,et al.  Bulk Cytoplasmic Actin and Its Functions in Meiosis and Mitosis , 2011, Current Biology.

[15]  Alice Louise Bull,et al.  Stages of living embryos in the jewel wasp Mormoniella (nasonia) vitripennis (walker) (hymenoptera: pteromalidae) , 1982 .

[16]  E. Schejter,et al.  Mutations in centrosomin reveal requirements for centrosomal function during early Drosophila embryogenesis , 1999, Current Biology.

[17]  D. Glover,et al.  From centriole biogenesis to cellular function: Centrioles are essential for cell division at critical developmental stages , 2008, Cell cycle.

[18]  G. Schubiger,et al.  How an actin network might cause fountain streaming and nuclear migration in the syncytial Drosophila embryo [published erratum appears in J Cell Biol 1995 Sep;130(5):1231-4] , 1994, The Journal of cell biology.

[19]  G. C. Rogers,et al.  Functional coordination of three mitotic motors in Drosophila embryos. , 2000, Molecular biology of the cell.

[20]  D. Anderson.  The Embryology of Dacus tryoni (Frogg.) [Diptera, Trypetidae (= Tephritidae)], the Queensland Fruit-Fly , 1962 .

[21]  H. Gutzeit,et al.  Nuclear division and migration during early embryogenesis of Bradysia tritici coquillet (syn. Sciara ocellaris) (diptera : Sciaridae) , 1986 .

[22]  M. Bate,et al.  The development of Drosophila melanogaster , 1993 .

[23]  Alex Groisman,et al.  High-throughput and high-resolution flow cytometry in molded microfluidic devices. , 2006, Analytical chemistry.

[24]  E. Salmon,et al.  Microtubules Remodel Actomyosin Networks in Xenopus Egg Extracts via Two Mechanisms of F-Actin Transport , 2000, The Journal of cell biology.

[25]  Daniel J. Needleman,et al.  Evidence for an Upper Limit to Mitotic Spindle Length , 2008, Current Biology.

[26]  A. Hyman,et al.  Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos , 2010, Development.

[27]  E. Schejter,et al.  Microtubule‐dependent organization of subcortical microfilaments in the early Drosophila embryo , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[28]  G. von Dassow,et al.  Action at a distance during cytokinesis , 2009, The Journal of cell biology.

[29]  Asynchronous mitotic domains during blastoderm formation inMusca domestica L. (Diptera) , 1991, Roux's archives of developmental biology.

[30]  C. Nüsslein-Volhard,et al.  The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila , 1986, Cell.

[31]  W Sullivan,et al.  Incomplete sister chromatid separation is the mechanism of programmed chromosome elimination during early Sciara coprophila embryogenesis. , 1996, Development.

[32]  KO Hatanaka,et al.  Retarded nuclear migration in Drosophila embryos with aberrant F-actin reorganization caused by maternal mutations and by cytochalasin treatment. , 1991, Development.

[33]  B. Edgar,et al.  Using inhibitors to study embryogenesis. , 1994, Methods in cell biology.

[34]  Thomas C Kaufman,et al.  Zygotic development without functional mitotic centrosomes , 2001, Current Biology.

[35]  L. Matzkin,et al.  Egg size, embryonic development time and ovoviviparity in Drosophila species , 2009, Journal of evolutionary biology.

[36]  F. Baluška,et al.  Eukaryotic cells and their cell bodies: Cell Theory revised. , 2004, Annals of botany.

[37]  M. Riparbelli,et al.  Cytochalasin induces spindle fusion in the syncytial blastoderm of the early Drosophila embryo , 1992, Biology of the cell.

[38]  M. Riparbelli,et al.  Centriole and centrosome cycle in the early Drosophila embryo. , 1990, Journal of cell science.

[39]  P. Gönczy.  Mechanisms of asymmetric cell division: flies and worms pave the way , 2008, Nature Reviews Molecular Cell Biology.

[40]  S. Zipursky,et al.  Induction of Drosophila eye development by decapentaplegic. , 1997, Development.

[41]  E. Wieschaus,et al.  Functional elements of the cytoskeleton in the early Drosophila embryo. , 1993, Annual review of cell biology.

[42]  A. Mazumdar,et al.  How one becomes many: Blastoderm cellularization in Drosophila melanogaster , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[43]  J. Scholey,et al.  Mitotic spindle dynamics in Drosophila. , 2007, International review of cytology.

[44]  S. Fouix,et al.  Jupiter, a new Drosophila protein associated with microtubules. , 2006, Cell motility and the cytoskeleton.

[45]  T. Mitchison,et al.  A Model for Cleavage Plane Determination in Early Amphibian and Fish Embryos , 2010, Current Biology.

[46]  G. Odell,et al.  Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryos. , 2000, Development.

[47]  M Bettencourt-Dias,et al.  Revisiting the Role of the Mother Centriole in Centriole Biogenesis , 2007, Science.

[48]  Jonathon Howard,et al.  The Distribution of Active Force Generators Controls Mitotic Spindle Position , 2003, Science.

[49]  E. Bearer.  Actin in the Drosophila embryo: Is there a relationship to developmental cue localization? , 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.

[50]  G. Schubiger,et al.  Dynamic changes in microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embryo , 1993, The Journal of cell biology.