ELECTROCHEMICAL SENSORS WITH PHARMACEUTICAL APPLICATIONS BASED ON POLYMER INCLUSION MEMBRANES CONTAINING PHOSPHOMOLYBDIC ACID COMPLEXES

The article presents the construction and characterization of selective membrane sensors based on electroactive material incorporated in PVC matrix for the determination of ranitidine, famotidine and nizatidine, which use their complexes with phosphomolybdic acid as their electroactive material. Ion-pair complexes have been synthesized and characterized in terms of structure, composition and solubility. The optimal proportion has been established in order to obtain homogeneous, thin, elastic, mechanically resistant membranes and to provide the best analytical response. Optimal operating conditions have been determined. The linear response, quantification limit, response time and selectivity were studied for each electrode. The electrodes have been used for the potentiometric determination of H2 antihistamines from pharmaceutical products.

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