Emerging role of ubiquitination/deubiquitination modification of PD-1/PD-L1 in cancer immunotherapy
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Xiaolong Yan | Yi Hu | Yizeng Fan | Yingtong Feng | Peng Ding | Zhiqiang Ma | Minghong Pan | C. Shao | Jing Han | Di Huang | Yimeng Zhang
[1] Y. She,et al. N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer , 2021, Molecular cancer.
[2] Lei Wang,et al. LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22 , 2021, Frontiers in Cell and Developmental Biology.
[3] Jianlong Li,et al. Identification of vitamin B6 as a PD-L1 suppressor and an adjuvant for cancer immunotherapy. , 2021, Biochemical and biophysical research communications.
[4] Fang Wang,et al. Aldehyde Dehydrogenase 2 Mediates Alcohol‐Induced Colorectal Cancer Immune Escape through Stabilizing PD‐L1 Expression , 2021, Advanced science.
[5] Minhua Liang,et al. Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways. , 2021, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
[6] Jinfang Zhang,et al. Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1 , 2020, Cell Death & Differentiation.
[7] Hong-min Liu,et al. Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing , 2020, Acta pharmaceutica Sinica. B.
[8] Yan Wang,et al. KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression , 2020, Proceedings of the National Academy of Sciences.
[9] N. Tang,et al. 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1 , 2020, Journal for ImmunoTherapy of Cancer.
[10] Bo Xu,et al. Rho‐associated protein kinase‐dependent moesin phosphorylation is required for PD‐L1 stabilization in breast cancer , 2020, Molecular oncology.
[11] Gang Wu,et al. USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer , 2020, Theranostics.
[12] S. Fan,et al. The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells , 2020, Cell Communication and Signaling.
[13] M. Yin,et al. Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5 , 2020, Acta pharmaceutica Sinica. B.
[14] Yuhe Wu,et al. KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway , 2020, Cancer management and research.
[15] A. Clark,et al. SPOP and cancer: a systematic review. , 2020, American journal of cancer research.
[16] Lianhong Li,et al. PD-1/PD-L1 pathway: current researches in cancer. , 2020, American journal of cancer research.
[17] M. Ma,et al. USP9X promotes the progression of hepatocellular carcinoma by regulating beta-catenin , 2020, Irish Journal of Medical Science (1971 -).
[18] Hong Wang,et al. Enhanced histone H3 acetylation of the PD-L1 promoter via the COP1/c-Jun/HDAC3 axis is required for PD-L1 expression in drug-resistant cancer cells , 2020, Journal of Experimental & Clinical Cancer Research.
[19] X-H Zhang,et al. MiR-135b-5p inhibits the progression of malignant melanoma cells by targeting RBX1. , 2020, European review for medical and pharmacological sciences.
[20] G. Duan,et al. E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation , 2020, Molecular and Cellular Biology.
[21] Yichi Xu,et al. The emerging role of SPOP protein in tumorigenesis and cancer therapy , 2020, Molecular Cancer.
[22] B. Stanger,et al. Tumor Cell–Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer , 2019, Cancer Immunology Research.
[23] Bangshun He,et al. Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway , 2019, Cell Death & Differentiation.
[24] Mostafa E. Belghasem,et al. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth , 2019, Scientific Reports.
[25] I. Dikic,et al. Cellular quality control by the ubiquitin-proteasome system and autophagy , 2019, Science.
[26] Yonghong Sun,et al. Phosphorylation of HSF1 by PIM2 induces PD-L1 expression and promotes tumor growth in breast cancer. , 2019, Cancer research.
[27] Qiaojun He,et al. Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses , 2019, Acta pharmaceutica Sinica. B.
[28] D. Tang,et al. STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling , 2019, Cancer science.
[29] Xing Huang,et al. USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity , 2019, Cancer Immunology Research.
[30] Liang Deng,et al. Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation , 2019, Oncogene.
[31] C. Das,et al. Uncovering the Structural Basis of a New Twist in Protein Ubiquitination. , 2019, Trends in biochemical sciences.
[32] I. Bezsonova,et al. USP7: Structure, substrate specificity, and inhibition. , 2019, DNA repair.
[33] P. Nghiem,et al. Faculty Opinions recommendation of Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[34] C. Curran,et al. PD-1 immunobiology in systemic lupus erythematosus. , 2019, Journal of autoimmunity.
[35] R. Pulido,et al. A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma , 2019, Current Urology Reports.
[36] M. Yao,et al. DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up‐regulates PD‐L1 in non‐small‐cell lung cancer , 2019, Experimental cell research.
[37] Min Zhang,et al. MiR‐940 promotes the proliferation and migration of gastric cancer cells through up‐regulation of programmed death ligand‐1 expression , 2018, Experimental cell research.
[38] Wei Yang,et al. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells , 2018, Nature.
[39] Zhining Fan,et al. Upregulation of HRD1 promotes cell migration and invasion in colon cancer , 2018, Molecular and Cellular Biochemistry.
[40] Zhaojian Liu,et al. HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression. , 2018, Cellular signalling.
[41] P. Dong,et al. Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion , 2018, Front. Oncol..
[42] Shaoru Li,et al. MicroRNA-302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1. , 2018, Experimental and therapeutic medicine.
[43] W. Symmans,et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. , 2018, Molecular cell.
[44] Zhou Aiping,et al. Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin‐specific peptidase 9, X‐linked in oral squamous cell carcinoma , 2018, Cancer medicine.
[45] J. Huo,et al. F-box proteins involved in cancer-associated drug resistance. , 2018, Oncology letters.
[46] J. Meza,et al. Loss of the Nuclear Pool of Ubiquitin Ligase CHIP/STUB1 in Breast Cancer Unleashes the MZF1-Cathepsin Pro-oncogenic Program. , 2018, Cancer research.
[47] Yuntao Xie,et al. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing , 2018, Nature.
[48] Jedd D. Wolchok,et al. Cancer immunotherapy using checkpoint blockade , 2018, Science.
[49] Ce Li,et al. E3 ubiquitin ligases Cbl‐b and c‐Cbl downregulate PD‐L1 in EGFR wild‐type non‐small cell lung cancer , 2018, FEBS letters.
[50] J. Taube,et al. PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression , 2018, The Journal of clinical investigation.
[51] Arash Salmaninejad,et al. PD-1 and cancer: molecular mechanisms and polymorphisms , 2018, Immunogenetics.
[52] N. H. Nagoor,et al. MiR-378 and MiR-1827 Regulate Tumor Invasion, Migration and Angiogenesis in Human Lung Adenocarcinoma by Targeting RBX1 and CRKL, Respectively , 2018, Journal of Cancer.
[53] Y-S Wang,et al. Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells. , 2017, European review for medical and pharmacological sciences.
[54] S. Dawson,et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity , 2017, Nature.
[55] S. Staibano,et al. A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma , 2017, Oncotarget.
[56] A. Surolia,et al. Role of glycosylation in nucleating protein folding and stability. , 2017, The Biochemical journal.
[57] H. Horlings,et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators , 2017, Nature.
[58] K. Manova,et al. Squamous cell carcinoma–related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission , 2017, The Journal of Biological Chemistry.
[59] K. Flaherty,et al. Targeted agents and immunotherapies: optimizing outcomes in melanoma , 2017, Nature Reviews Clinical Oncology.
[60] Y. Shang,et al. USP9X regulates centrosome duplication and promotes breast carcinogenesis , 2017, Nature Communications.
[61] P. Pandolfi,et al. Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones , 2017, Oncotarget.
[62] Peter C. Hollenhorst,et al. Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma , 2017, Nature Communications.
[63] J. Wargo,et al. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy , 2017, Cell.
[64] G. Hortobagyi,et al. PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression , 2017, Clinical Cancer Research.
[65] R. Clark,et al. Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation , 2017, Front. Immunol..
[66] G. Hortobagyi,et al. Deubiquitination and Stabilization of PD-L1 by CSN5. , 2016, Cancer cell.
[67] Wei Wang,et al. A meta-analysis of efficacy and safety of antibodies targeting PD-1/PD-L1 in treatment of advanced nonsmall cell lung cancer , 2016, Medicine.
[68] Arash Salmaninejad,et al. PD-1/PD-L and autoimmunity: A growing relationship. , 2016, Cellular immunology.
[69] D. Sterner,et al. Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity , 2016, EBioMedicine.
[70] Jun Yao,et al. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity , 2016, Nature Communications.
[71] S. Wood,et al. Deubiquitylating enzyme, USP9X, regulates proliferation of cells of head and neck cancer lines , 2016, Cell proliferation.
[72] Jianxun Song,et al. The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity , 2016, Nature Communications.
[73] Junnian Zheng,et al. The emerging roles of Jab1/CSN5 in cancer , 2016, Medical Oncology.
[74] A. Satelli,et al. Potential role of nuclear PD-L1 expression in cell-surface vimentin positive circulating tumor cells as a prognostic marker in cancer patients , 2016, Scientific Reports.
[75] Y. Shang,et al. Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. , 2016, The Journal of clinical investigation.
[76] Chuan-chao He,et al. Regulation mechanism of Fbxw7-related signaling pathways (Review). , 2015, Oncology reports.
[77] Yanju Ma,et al. The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis , 2015, Oncotarget.
[78] L. Chin,et al. Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system , 2015, Cellular and Molecular Life Sciences.
[79] A. Ciechanover. The unravelling of the ubiquitin system , 2015, Nature Reviews Molecular Cell Biology.
[80] M. Azuma,et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. , 2015, Oral oncology.
[81] J. Gécz,et al. La FAM fatale: USP9X in development and disease , 2015, Cellular and Molecular Life Sciences.
[82] Aristotelis Tsirigos,et al. FBXW7 modulates cellular stress response and metastatic potential via HSF1 post-translational modification , 2015, Nature Cell Biology.
[83] Xin Liu,et al. Colon cancer bears overexpression of OTUB1. , 2014, Pathology, research and practice.
[84] Yanju Ma,et al. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells , 2014, Molecular Cancer.
[85] K. Nakayama,et al. Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells , 2014, British Journal of Cancer.
[86] Jun Yu,et al. CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer. , 2014, Carcinogenesis.
[87] Cuiping Liu,et al. A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China , 2014, International journal of genomics.
[88] Christopher E. Berndsen,et al. New insights into ubiquitin E3 ligase mechanism , 2014, Nature Structural &Molecular Biology.
[89] M. Gleave,et al. Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer , 2014, Proceedings of the National Academy of Sciences.
[90] S. Zheng,et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. , 2013, Immunity.
[91] Yigang Zeng,et al. Overexpression of RING box protein‐1 (RBX1) associated with poor prognosis of non‐muscle‐invasive bladder transitional cell carcinoma , 2013, Journal of surgical oncology.
[92] Patrick G. A. Pedrioli,et al. Ubiquitylation-dependent localization of PLK1 in mitosis , 2013, Nature Cell Biology.
[93] W. Goessling,et al. SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2 , 2012, The Journal of experimental medicine.
[94] G. Kristiansen,et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma , 2012, Nature.
[95] S. Bogaerts,et al. Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. , 2011, The Journal of clinical investigation.
[96] N. Donato,et al. Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. , 2010, Cancer research.
[97] S. Broderick,et al. SCCRO promotes glioma formation and malignant progression in mice. , 2010, Neoplasia.
[98] S. Rosenberg,et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. , 2009, Blood.
[99] David Komander,et al. Breaking the chains: structure and function of the deubiquitinases , 2009, Nature Reviews Molecular Cell Biology.
[100] J. Riley. PD‐1 signaling in primary T cells , 2009, Immunological reviews.
[101] J. Kappes,et al. COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. , 2009, The American journal of pathology.
[102] Pier Paolo Pandolfi,et al. The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network , 2008, Nature.
[103] G. Freeman,et al. PD-1 and its ligands in tolerance and immunity. , 2008, Annual review of immunology.
[104] J. Yates,et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. , 2007, Nature.
[105] G. Freeman,et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection , 2007, Nature Immunology.
[106] Xin-Yuan Fu,et al. CHIP Controls the Sensitivity of Transforming Growth Factor-β Signaling by Modulating the Basal Level of Smad3 through Ubiquitin-mediated Degradation* , 2005, Journal of Biological Chemistry.
[107] J. Kato,et al. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3 , 2005, The EMBO journal.
[108] A. Lanfranco,et al. CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms , 2004, Molecular and Cellular Biology.
[109] Timothy Cardozo,et al. Systematic analysis and nomenclature of mammalian F-box proteins. , 2004, Genes & development.
[110] Patrick Dowd,et al. The ubiquitin ligase COP1 is a critical negative regulator of p53 , 2004, Nature.
[111] B. Doble,et al. GSK-3: tricks of the trade for a multi-tasking kinase , 2003, Journal of Cell Science.
[112] Keiji Tanaka,et al. CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded protein , 2001, EMBO reports.
[113] P. Cohen,et al. The renaissance of GSK3 , 2001, Nature Reviews Molecular Cell Biology.
[114] H. Nishina,et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b , 2000, Nature.
[115] Jianping Zhou,et al. MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1). , 2018, Oncology research.
[116] C. Curran,et al. PD-1 immunobiology in autoimmune hepatitis and hepatocellular carcinoma. , 2017, Seminars in oncology.
[117] Yu Yao,et al. Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway. , 2015, Trends in molecular medicine.
[118] T. O'Brien,et al. Therapeutic strategies within the ubiquitin proteasome system , 2010, Cell Death and Differentiation.