Clinical and Psycological Telemonitoring and Telecare of High Risk Patientswith Chronic Heart Failure through Wireless Technologies: The Icaros Project

Background: Disease management is mandatory for the home care of most patients with chronic heart failure. We report the results of ICAROS (Integrated care vs Conventional intervention in cArdiac failure patients: Randomized Open label Study), an Italian trial of telemonitoring and telecare combining wireless and mobile technologies to obtain optimal therapeutic control, fast and effective interpretation of clinical data and improved patients’ adherence.Methods: Eighty patients were randomized before hospital discharge after an episode of acute heart failure, to a usual care group (UC) (n=40: follow-up at our Outpatients’ clinic) or to an integrated management group (IM) (n=40: patients learned to use a PDA computer and kept in touch daily with our Centre to receive instructions, encouragement, clinical and psychological assistance. Results: At enrolment, groups were similar for age (UC 73 ± 3 years; IM 71 ± 2 years); NYHA class (UC 2.90 ± 0.69; IM 3.08 ± 0.57), left ventricular function (EF%) (UC 32 ± 8%; IM 32 ± 7%), plasma levels of BNP (UC 361 ± 72 pg/ml; IM 314 ± 94 pg/ml). At one-year follow-up, IM patients showed better adherence, reduction of anxiety and depression and lower NYHA class and plasma levels of BNP with respect to UC patients (NYHA: 2.08 ± 0.38; BNP: 202 ± 127 pg/ml, p<0.05 vs UC patients). Mortality and hospital re-admissions for congestive heart failure were also reduced in IM patients (p<0.05).Conclusions: In ICAROS, regular acquisition by wireless technologies of clinical and psychological data provided a good model for clinical decision-making, determining better quality of life and reducing mortality and hospitalizations.

[1]  S. Stewart,et al.  Detecting early clinical deterioration in chronic heart failure patients post‐acute hospitalisation—a critical component of multidisciplinary, home‐based intervention? , 2002, European journal of heart failure.

[2]  R. Califf,et al.  Outcomes and costs within a disease management program for advanced congestive heart failure. , 1998, American heart journal.

[3]  R. Spitzer,et al.  The PHQ-9: validity of a brief depression severity measure. , 2001, Journal of general internal medicine.

[4]  L. Tavazzi,et al.  Current presentation and management of heart failure in cardiology and internal medicine hospital units: a tale of two worlds--the TEMISTOCLE study. , 2003, American heart journal.

[5]  David Tepper,et al.  Noninvasive Home Telemonitoring for Patients With Heart Failure at High Risk for Recurrent Admission and Death , 2005 .

[6]  D. Moser,et al.  Team Management of Patients With Heart Failure: A Statement for Healthcare Professionals From the Cardiovascular Nursing Council of the American Heart Association , 2000, Circulation.

[7]  Juerg Schwitter,et al.  ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 , 2010, European journal of heart failure.

[8]  C. Spielberger,et al.  Measuring anxiety and anger with the State-Trait Anxiety Inventory (STAI) and the State-Trait Anger Expression Inventory (STAXI). , 1999 .

[9]  K. Akosah,et al.  Improving care for patients with chronic heart failure in the community: the importance of a disease management program. , 2002, Chest.

[10]  N. Freemantle,et al.  Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey , 2002, The Lancet.

[11]  M. Cowie,et al.  Improving survival in the 6 months after diagnosis of heart failure in the past decade: population-based data from the UK , 2009, Heart.

[12]  C. Furberg,et al.  Assessment of quality of life in clinical trials of cardiovascular therapies. , 1984, The American journal of cardiology.

[13]  S. Scalvini,et al.  Effect of home-based telecardiology on chronic heart failure: Costs and outcomes , 2005, Journal of telemedicine and telecare.

[14]  M. Naylor,et al.  Comprehensive discharge planning and home follow-up of hospitalized elders: a randomized clinical trial. , 1999, JAMA.

[15]  A. Jerant,et al.  Reducing the Cost of Frequent Hospital Admissions for Congestive Heart Failure: A Randomized Trial of a Home Telecare Intervention , 2001, Medical care.

[16]  Sally Wells,et al.  Compliance and effectiveness of 1 year's home telemonitoring. The report of a pilot study of patients with chronic heart failure , 2001, European journal of heart failure.

[17]  A. Hoes,et al.  Clinical epidemiology of heart failure , 2007, Heart.

[18]  N. Bayley,et al.  Failure , 1890, The Hospital.

[19]  M. Senni,et al.  [Continuity of care in patients with cardiac failure after acute event]. , 2010, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.

[20]  Simon Stewart,et al.  Effects of a multidisciplinary, home-based intervention on planned readmissions and survival among patients with chronic congestive heart failure: a randomised controlled study , 1999, The Lancet.

[21]  F. Rutten,et al.  Differences between general practitioners and cardiologists in diagnosis and management of heart failure: a survey in every‐day practice , 2003, European journal of heart failure.

[22]  B. Fagerberg,et al.  Feasibility of a nurse-monitored, outpatient-care programme for elderly patients with moderate-to-severe, chronic heart failure. , 1998, European heart journal.

[23]  K. White,et al.  Clinical epidemiology. , 1983, International journal of epidemiology.

[24]  H. Krumholz,et al.  Telemonitoring in patients with heart failure. , 2010, The New England journal of medicine.

[25]  V. Hasselblad,et al.  Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study. , 1999, Archives of internal medicine.

[26]  Simon Stewart,et al.  Home-Based Intervention in Congestive Heart Failure: Long-Term Implications on Readmission and Survival , 2002, Circulation.

[27]  R. Carney,et al.  A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. , 1995, The New England journal of medicine.

[28]  D. Renlund,et al.  The cost of medical management in advanced heart failure during the final two years of life. , 2008, Journal of cardiac failure.

[29]  L. Allen,et al.  Critical elements of clinical follow‐up after hospital discharge for heart failure: insights from the EVEREST trial , 2010, European journal of heart failure.

[30]  Angelo Compare,et al.  Continuità assistenziale nei pazienti con scompenso cardiaco: ruolo delle tecnologie wireless per la telemedicina. Il progetto ICAROS , 2007 .

[31]  L. Badano,et al.  Specialty-related differences in the epidemiology, clinical profile, management and outcome of patients hospitalized for heart failure; the OSCUR study. Oucome dello Scompenso Cardiaco in relazione all'Utilizzo delle Risore. , 2001, European heart journal.

[32]  A. Hoes,et al.  Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. , 2005, European heart journal.

[33]  L. Green,et al.  Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence , 1986, Medical care.

[34]  Brad Smith,et al.  Cost-effectiveness of telephonic disease management in heart failure. , 2008, The American journal of managed care.

[35]  E. Molinari,et al.  [Disease management for heart failure patients: role of wireless technologies for telemedicine. The ICAROS project]. , 2007, Giornale italiano di cardiologia.

[36]  Piotr Ponikowski,et al.  Home telemonitoring in heart failure patients: the HHH study (Home or Hospital in Heart Failure) , 2009, European journal of heart failure.

[37]  Perry M. Elliott,et al.  ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 , 2010, European journal of heart failure.

[38]  Longjian Liu Changes in cardiovascular hospitalization and comorbidity of heart failure in the United States: findings from the National Hospital Discharge Surveys 1980-2006. , 2011, International journal of cardiology.

[39]  C. Holly Structured telephone support or telemonitoring programmes for patients with chronic heart failure , 2011 .

[40]  A. de Silvestri,et al.  A meta-analysis of remote monitoring of heart failure patients. , 2009, Journal of the American College of Cardiology.

[41]  A. Rigby,et al.  Noninvasive home telemonitoring for patients with heart failure at high risk of recurrent admission and death: the Trans-European Network-Home-Care Management System (TEN-HMS) study. , 2005, Journal of the American College of Cardiology.

[42]  Emily Seto,et al.  Cost comparison between telemonitoring and usual care of heart failure: a systematic review. , 2008, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[43]  Simonetta Scalvini,et al.  A pilot study of nurse-led, home-based telecardiology for patients with chronic heart failure , 2004, Journal of telemedicine and telecare.