Flg.1 GH (ng/ml) mean values (X ± SE; ng/ml) and AUe (x ± SE; ng/ml x 120 min) after administration of GHRH 100 Jl i. v. on day 9 of the menstrual cycle and DMI50 mg i. v. on day 10 of the menstrual cycle in healthy female subjects. GH (ng/ml) mean values (x ± SE; ng/ml) and AUe (x ± SE; ng/ml x 120min) after administration of GHRH 100 Jlg i. v. on day 190fthe menstrual cycle and DMI 50 mg i. v. on day 20 of the menstrual cycle in healthy female subjects. GH (ng/ml) mean values (x ± SE; ng/ml) and AUe (x ± SE: ng/ml x 120 minI after administration of GHRH 100 Jlg i. v. and DMI75 mg i. m. in healthy male subjects. In our first study, we examined 10 healthy male subjects of nonnal weight aged between 18 and 35. On the first day ofthe trial, GHRH 100 Jlg i. v. wasgiven, on theseeondday DMI 75 mg i. m. In our seeond study, 13 healthy female subjeets were included. They did not use honnonal contraceptives and ha a nonnal temperature curve with ovulation with no menstrual disturbanees. The healthy female subjects measured their temperature daily for two menstrual cycles. They received GHRH 100 Jlg i. v. on the 9th and 19th day oftheir menstrual cylce and DMI 50 mg i. v. on the 10th and 20th day oftheir menstrual eycle. Prior to the experiments, the healthy male and female subjeets were infonned and eonsented to participation in the study. They were examined physicaIly, EEG, ECG were perfonned and routine blood tests were carried out. During the 4 weeks before the trial they had taken no medication and in the previous 24 hours had drunk no alcohoI. Their last meal was at 22.00 h on the preceding evening and they had slept sufficiently. During the trial the healthy subjeets stayed in bed in a special room sereened from stressful influenees. The trials started at 8.00 h ± 30 min. An intraveous catheter was inserted into the antieubital vein which was kept open by physiologie saline solution. At t = -60 min, t = 0 min, and then every 15 min up to t = 120min blood was taken and centrifuged. Then the serum was frozen at -20°C until it was radioimmunologically analysed. GHRH 100 Jlg i. v. (Somatobiss) was administered via a perfusor in 60 see at t = 0 min immediateIy after blood withdrawaI. lntroduction