Rewired ERK-JNK signaling pathways in melanoma.

[1]  C. Weston,et al.  The JNK signal transduction pathway. , 2007, Current opinion in genetics & development.

[2]  J. Blenis,et al.  MAPK signal specificity: the right place at the right time. , 2006, Trends in biochemical sciences.

[3]  Dan Yang,et al.  NF-κB Is Required for UV-Induced JNK Activation via Induction of PKCδ , 2006 .

[4]  L. Bardwell,et al.  Characterization of an ERK-binding Domain in Microphthalmia-associated Transcription Factor and Differential Inhibition of ERK2-mediated Substrate Phosphorylation* , 2005, Journal of Biological Chemistry.

[5]  H. Kung,et al.  c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases. , 2005, Experimental cell research.

[6]  Z. Ronai,et al.  Receptor for RACK1 Mediates Activation of JNK by Protein Kinase C , 2005 .

[7]  Jun Qin,et al.  Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin , 2005 .

[8]  W. Kaelin,et al.  The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. , 2005, Cancer cell.

[9]  U. Kikkawa,et al.  Protein kinase C in melanoma , 2005, Cancer and Metastasis Reviews.

[10]  Z. Ronai,et al.  Ubiquitin Chains in the Ladder of MAPK Signaling , 2005, Science's STKE.

[11]  W. Shih,et al.  Detection of B-RAF and N-RAS mutations in human melanoma. , 2005, Journal of the American College of Surgeons.

[12]  J. Utikal,et al.  Additional Cyclin D(1) gene copies associated with chromosome 11 aberrations in cutaneous malignant melanoma. , 2005, International journal of oncology.

[13]  J. Chung,et al.  Heat shock-induced matrix metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine interleukin-6 loop. , 2004, The Journal of investigative dermatology.

[14]  J. Inazawa,et al.  Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines , 2004, Oncogene.

[15]  U. Moens,et al.  What turns CREB on? , 2004, Cellular signalling.

[16]  M. T. de la Fuente,et al.  Abnormal cell cycle regulation in primary human uveal melanoma cultures , 2004, Journal of cellular biochemistry.

[17]  N. Jones,et al.  Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Ajay N. Jain,et al.  Determinants of BRAF mutations in primary melanomas. , 2003, Journal of the National Cancer Institute.

[19]  W. Hait,et al.  Detection of mutations in the mitogen-activated protein kinase pathway in human melanoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[20]  M. Herlyn,et al.  Reciprocal regulation of MelCAM and AKT in human melanoma , 2003, Oncogene.

[21]  P. Cohen,et al.  A reinvestigation of the multisite phosphorylation of the transcription factor c‐Jun , 2003, The EMBO journal.

[22]  D. Polsky,et al.  Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues. , 2003, Cancer research.

[23]  G. de Rosa,et al.  Expression of cyclin-D1 in uveal malignant melanoma. , 2003, Anticancer research.

[24]  Ajamete Kaykas,et al.  Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements , 2003, Current Biology.

[25]  P. Cohen,et al.  The specificities of protein kinase inhibitors: an update. , 2003, The Biochemical journal.

[26]  D. Elder,et al.  Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. , 2003, Cancer research.

[27]  E. Wagner,et al.  Liver Tumor Development c-Jun Antagonizes the Proapoptotic Activity of p53 , 2003, Cell.

[28]  R. Prywes,et al.  ATF1 Phosphorylation by the ERK MAPK Pathway Is Required for Epidermal Growth Factor-induced c-jun Expression* , 2002, The Journal of Biological Chemistry.

[29]  G. Johnson,et al.  Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases , 2002, Science.

[30]  H. Stein,et al.  Aberrantly expressed c‐Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF‐κB , 2002, The EMBO journal.

[31]  P. Meltzer,et al.  A genome-based strategy uncovers frequent BRAF mutations in melanoma. , 2002, Cancer cell.

[32]  Ben Shneiderman,et al.  Interactively Exploring Hierarchical Clustering Results , 2002, Computer.

[33]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[34]  D. Pinkel,et al.  Cyclin D1 is a candidate oncogene in cutaneous melanoma. , 2002, Cancer research.

[35]  H. Pehamberger,et al.  Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage , 2002, Melanoma research.

[36]  M. Karin,et al.  AP-1 as a regulator of cell life and death , 2002, Nature Cell Biology.

[37]  P. Cohen,et al.  MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts , 2002, Molecular and Cellular Biology.

[38]  S. Hirohashi,et al.  Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1 , 2002, Molecular pathology : MP.

[39]  Daria Mochly-Rosen,et al.  Adaptor proteins in protein kinase C-mediated signal transduction , 2001, Oncogene.

[40]  P. Vogt,et al.  Jun, the oncoprotein , 2001, Oncogene.

[41]  D. Levy,et al.  Cooperation between STAT3 and c-jun suppresses Fas transcription. , 2001, Molecular cell.

[42]  B. Hengerer,et al.  RACK1 IS UP‐REGULATED IN ANGIOGENESIS AND HUMAN CARCINOMAS , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  R. Davis,et al.  Signal Transduction by the JNK Group of MAP Kinases , 2000, Cell.

[44]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .

[45]  J. Mester,et al.  Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[46]  D. Ginty,et al.  A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos , 1998, Molecular and Cellular Biology.

[47]  D. Elder,et al.  Melanoma cell lines from different stages of progression and their biological and molecular analyses , 1997, Melanoma research.

[48]  J. Bartek,et al.  The retinoblastoma protein pathway and the restriction point. , 1996, Current opinion in cell biology.

[49]  Z. Ronai,et al.  Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. , 1996, Oncogene.

[50]  B. Spiegelman,et al.  Cellular transformation and malignancy induced by ras require c-jun , 1996, Molecular and cellular biology.

[51]  E. Hovig,et al.  Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. , 1996, British Journal of Cancer.

[52]  M. Karin.  The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*) , 1995, The Journal of Biological Chemistry.

[53]  M. Karin,et al.  c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases , 1994, Molecular and cellular biology.

[54]  F. Zunino,et al.  Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes , 1994, International journal of cancer.

[55]  J. Caldwell,et al.  Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[56]  J. Bartek,et al.  Molecular pathology of the cell cycle in human cancer cells , 1993, Stem cells.

[57]  A. Bitonti,et al.  Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C. , 1992, Cancer research.

[58]  Peter Angel,et al.  The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 , 1988, Cell.

[59]  Z. Ronai,et al.  Altered Signal Transduction in Melanoma , 2006 .

[60]  Dan Yang,et al.  NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. , 2006, Molecular cell.

[61]  Z. Ronai,et al.  RACK1 mediates activation of JNK by protein kinase C [corrected]. , 2005, Molecular cell.

[62]  Jun Qin,et al.  Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. , 2005, Molecular cell.

[63]  M. Bar‐eli,et al.  Transcriptional regulation of metastasis-related genes in human melanoma , 2004, Clinical & Experimental Metastasis.

[64]  J. Downward.  Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.