Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in epstein‐barr‐virus‐positive nasopharyngeal carcinoma cells

Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein‐Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of tumor‐infiltrating lymphocytes, NPC cells obviously escape immune surveillance directed to EBV antigens. Previous investigations carried out on EBV‐positive Burkitt lymphoma (BL) cells have shown that this fact may be partially accounted for by a lack of expression of ICAM1 (CD54) and LFA3 (CD58). ICAM1 and LFA3 have therefore been investigated in fresh NPC biopsies and transplanted NPCs. With only I exception out of 9 cases, NPC cells appear to express high levels of ICAM I and low levels of LFA3. This is a complete inversion of the pattern observed in normal epithelial cells in vivo. Additional investigations will be required to determine to what extent these characteristics affect T‐cell interactions with NPC cells, specially in the process of EBV‐antigen recognition.

[1]  S. Miescher,et al.  Cytotoxic potential despite impaired activation pathways in T lymphocytes infiltrating nasopharyngeal carcinoma , 1991, International journal of cancer.

[2]  G. Lenoir,et al.  Structure and regulation of the blast-2/CD23 antigen in epithelial cells from nasopharyngeal carcinoma. , 1990, International immunology.

[3]  H. Sato,et al.  Novel transcription from the Epstein-Barr virus terminal EcoRI fragment, DIJhet, in a nasopharyngeal carcinoma , 1990, Journal of virology.

[4]  Timothy A. Springer,et al.  Adhesion receptors of the immune system , 1990, Nature.

[5]  B. Haynes,et al.  The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. , 1990, The Journal of investigative dermatology.

[6]  L. Young,et al.  Epstein–Barr virus latent membrane protein inhibits human epithelial cell differentiation , 1990, Nature.

[7]  N. Colburn,et al.  Transforming activity of nasopharyngeal carcinoma DNA detectable in mouse JB6 cells , 1989, International journal of cancer.

[8]  M. Lipinski,et al.  Establishment and characterization of three transplantable EBV‐containing nasopharyngeal carcinomas , 1988, International journal of cancer.

[9]  Pierre Busson,et al.  Expression of Epstein‐Barr virus‐encoded proteins in nasopharyngeal carcinoma , 1988, International journal of cancer.

[10]  A. Rickinson,et al.  Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein- Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance , 1988, The Journal of experimental medicine.

[11]  T. Tursz,et al.  Epstein-Barr virus gene expression in nasopharyngeal carcinoma. , 1988, The Journal of general virology.

[12]  B. Seed,et al.  ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM , 1988, Nature.

[13]  Michael Loran Dustin,et al.  Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein , 1987, The Journal of experimental medicine.

[14]  M. Lipinski,et al.  Epstein-Barr virus-containing epithelial cells from nasopharyngeal carcinoma produce interleukin 1 alpha. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Tursz,et al.  Epstein-Barr virus-containing B-cell line produces an interleukin 1 that it uses as a growth factor. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[16]  B. Seed.  An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2 , 1987, Nature.

[17]  Michael Loran Dustin,et al.  Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). , 1986, Journal of immunology.

[18]  H. Green,et al.  Enzymatic cross-linking of involucrin and other proteins by keratinocyte particulates in vitro , 1985, Cell.

[19]  R. Warnke,et al.  Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. , 1983, The New England journal of medicine.

[20]  D. Delia,et al.  Isolation of human haematopoietic progenitor cells using monoclonal antibodies , 1980, Nature.

[21]  D. Gospodarowicz,et al.  Permissive effect of the extracellular matrix on cell proliferation in vitro. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[22]  G. de‐Thé,et al.  Histopathology of nasopharyngeal carcinoma. Correlations with epidemiology, survival rates and other biological characteristics , 1979, Cancer.

[23]  G. Klein,et al.  Relationship between the Epstein‐Barr virus and undifferentiated nasopharyngeal carcinoma: Correlated nucleic acid hybridization and histopathological examination , 1977, International journal of cancer.

[24]  T. Phillips,et al.  Carcinoma of the nasopharynx. Review of 146 patients with emphasis on radiation dose and time factors. , 1972, American journal of surgery.