Biomaterials for tissue engineering of skin

Tissue-engineered skin has been in clinical use for 25 years and has developed greatly during this time. This review looks at the role biomaterials need to play in providing for epidermal cover, dermal replacement, and epidermal/dermal replacement, and describes the major problems that remain. The majority of biomaterials in clinical use are based on natural or extracted collagen. The clinical challenges in using these materials are highlighted throughout – specifically safety issues, improving the take of cultured cells on wound beds, improving the rate of neovascularization of tissue-engineered skin, and developing scaffolds that resist contraction and fibrosis.

[1]  Silvano Sozzani,et al.  The chemokine system in diverse forms of macrophage activation and polarization. , 2004, Trends in immunology.

[2]  R. Short,et al.  Plasma-polymerized surfaces for culture of human keratinocytes and transfer of cells to an in vitro wound-bed model. , 2003, Journal of biomedical materials research. Part A.

[3]  Joseph McGuire,et al.  USE OF CULTURED EPIDERMAL AUTOGRAFTS AND DERMAL ALLOGRAFTS AS SKIN REPLACEMENT AFTER BURN INJURY , 1986, The Lancet.

[4]  H. Green,et al.  Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes , 1977, Nature.

[5]  JOHN F. BURKE,et al.  Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn Injury , 1981, Annals of surgery.

[6]  Penny A. Johnson,et al.  Development and manufacture of an investigational human living dermal equivalent (ICX-SKN). , 2007, Regenerative medicine.

[7]  Nicola J Brown,et al.  Development of a reconstructed human skin model for angiogenesis , 2003, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[8]  Sheila MacNeil,et al.  Progress and opportunities for tissue-engineered skin , 2007, Nature.

[9]  Thorsten Walles,et al.  Engineering of a vascularized scaffold for artificial tissue and organ generation. , 2005, Biomaterials.

[10]  G. Boering,et al.  Resorbable materials of poly(L-lactide). VI. Plates and screws for internal fracture fixation. , 1987, Biomaterials.

[11]  R E Horch,et al.  Transplantation of cultured autologous keratinocytes in fibrin sealant biomatrix to resurface chronic wounds. , 2001, Transplantation proceedings.

[12]  Sheila MacNeil,et al.  Use of an in vitro model of tissue-engineered skin to investigate the mechanism of skin graft contraction. , 2006, Tissue engineering.

[13]  Michele De Luca,et al.  Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells , 2006, Nature Medicine.

[14]  S. MacNeil,et al.  Use of peracetic acid to sterilize human donor skin for production of acellular dermal matrices for clinical use , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[15]  H. Green,et al.  Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma , 1975, Cell.

[16]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[17]  R. Barrow,et al.  A Comparison of Conservative Versus Early Excision: Therapies in Severely Burned Patients , 1989, Annals of surgery.

[18]  R. M. Warner,et al.  Treatment of burns and chronic wounds using a new cell transfer dressing for delivery of autologous keratinocytes , 2005, European Journal of Plastic Surgery.

[19]  Ellen A. Lumpkin,et al.  Mechanisms of sensory transduction in the skin , 2007, Nature.

[20]  M. Hermans.  Clinical experience with glycerol-preserved donor skin treatment in partial thickness burns. , 1989, Burns, including thermal injury.

[21]  S. Boyce,et al.  The 1999 clinical research award. Cultured skin substitutes combined with Integra Artificial Skin to replace native skin autograft and allograft for the closure of excised full-thickness burns. , 1999, The Journal of burn care & rehabilitation.

[22]  W. Marston,et al.  The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. , 2003, Diabetes care.

[23]  Antonios G. Mikos,et al.  Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates , 1994, Cell transplantation.

[24]  J. Mulliken,et al.  GRAFTING OF BURNS WITH CULTURED EPITHELIUM PREPARED FROM AUTOLOGOUS EPIDERMAL CELLS , 1981, The Lancet.

[25]  Robert Langer,et al.  Advances in tissue engineering. , 2004, Current topics in developmental biology.

[26]  Elaine Fuchs,et al.  Scratching the surface of skin development , 2007, Nature.

[27]  J C M van Hest,et al.  Elastin as a biomaterial for tissue engineering. , 2007, Biomaterials.

[28]  C. Attinger,et al.  Consensus statement on negative pressure wound therapy (V.A.C. Therapy) for the management of diabetic foot wounds. , 2006, Ostomy/wound management.

[29]  Benjamin Chu,et al.  Structure and morphology changes during in vitro degradation of electrospun poly(glycolide-co-lactide) nanofiber membrane. , 2003, Biomacromolecules.

[30]  P T Khaw,et al.  KERATINOCYTE‐DRIVEN CONTRACTION OF RECONSTRUCTED HUMAN SKIN , 2001, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[31]  W. Jeffcoate,et al.  Randomized, controlled, single-blind study on use of autologous keratinocytes on a transfer dressing to treat nonhealing diabetic ulcers. , 2007, Regenerative medicine.

[32]  R. Short,et al.  Attachment of human keratinocytes to plasma co-polymers of acrylic acid/octa-1,7-diene and allyl amine/octa-1,7-diene , 1998 .

[33]  Seeram Ramakrishna,et al.  Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[34]  Ali Khademhosseini,et al.  Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration. , 2006, Biomaterials.

[35]  Stephen F Badylak,et al.  The extracellular matrix as a biologic scaffold material. , 2007, Biomaterials.

[36]  S. Macneil,et al.  Keratinocytes contract human dermal extracellular matrix and reduce soluble fibronectin production by fibroblasts in a skin composite model. , 1997, British journal of plastic surgery.

[37]  S. Mac Neil,et al.  Development of autologous human dermal–epidermal composites based on sterilized human allodermis for clinical use , 1999, The British journal of dermatology.

[38]  David Shier,et al.  Hole's Human Anatomy and Physiology , 1996 .

[39]  D. Herndon,et al.  Comparison of serial debridement and autografting and early massive excision with cadaver skin overlay in the treatment of large burns in children. , 1986, The Journal of trauma.

[40]  J. Chaudhuri,et al.  Porcine collagen crosslinking, degradation and its capability for fibroblast adhesion and proliferation , 2004, Journal of materials science. Materials in medicine.

[41]  Sheila MacNeil,et al.  Clinical experience using cultured epithelial autografts leads to an alternative methodology for transferring skin cells from the laboratory to the patient. , 2006, Regenerative medicine.

[42]  T. Okano,et al.  Thermo-responsive culture dishes allow the intact harvest of multilayered keratinocyte sheets without dispase by reducing temperature. , 2001, Tissue engineering.

[43]  S. MacNeil,et al.  A new autologous keratinocyte dressing treatment for non‐healing diabetic neuropathic foot ulcers , 2004, Diabetic medicine : a journal of the British Diabetic Association.

[44]  J. Foidart,et al.  Fibroblasts induce the assembly of the macromolecules of the basement membrane. , 1988, The Journal of investigative dermatology.

[45]  S. MacNeil,et al.  Tissue‐engineered buccal mucosa for substitution urethroplasty , 2004, BJU international.

[46]  Paul A. De Bank,et al.  Accelerated formation of multicellular 3‐D structures by cell‐to‐cell cross‐linking , 2007, Biotechnology and bioengineering.

[47]  V. Falanga.  Chronic wounds: pathophysiologic and experimental considerations. , 1993, The Journal of investigative dermatology.

[48]  Y. Bello,et al.  The role of graftskin (Apligraf) in difficult-to-heal venous leg ulcers. , 2002, Journal of wound care.

[49]  Tatsuo Ushiki,et al.  Collagen fibers, reticular fibers and elastic fibers. A comprehensive understanding from a morphological viewpoint. , 2002, Archives of histology and cytology.

[50]  S. MacNeil.  Tissue Engineered Skin Comes of Age , 2008 .

[51]  D. Fisher,et al.  Melanocyte biology and skin pigmentation , 2007, Nature.