Calpain research for drug discovery: challenges and potential

[1]  T. Saido,et al.  Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression , 2016, The Journal of Neuroscience.

[2]  M. Baudry,et al.  Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury , 2016, Neurobiology of Disease.

[3]  R. Eisenman,et al.  MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation , 2016, Proceedings of the National Academy of Sciences.

[4]  Yuanyuan Ruan,et al.  Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer , 2016, Scientific Reports.

[5]  A. Singleton,et al.  Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. , 2016, Cell reports.

[6]  K. Komurov,et al.  A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes , 2016, Nature Medicine.

[7]  D. McManus,et al.  The Tao survivorship of schistosomes: implications for schistosomiasis control. , 2016, International journal for parasitology.

[8]  Yan Gao,et al.  Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis , 2016, Molecular and Cellular Biology.

[9]  R. Campbell,et al.  Rational Design of Calpain Inhibitors Based on Calpastatin Peptidomimetics. , 2016, Journal of medicinal chemistry.

[10]  N. Khanlou,et al.  Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy. , 2016, Human molecular genetics.

[11]  O. Suchowersky,et al.  Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. , 2016, American journal of human genetics.

[12]  O. Sarig,et al.  Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis. , 2016, The Journal of investigative dermatology.

[13]  Andy H. Vo,et al.  Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ , 2016, PLoS genetics.

[14]  E. Stucke,et al.  Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. , 2016, JCI insight.

[15]  P. Serrano,et al.  The Effect of the Novel Blood-Brain Barrier Permeable Calpain Inhibitor Ala-1.0 in a Rat Model of Traumatic Brain Injury (P3.286) , 2016 .

[16]  L. Duong,et al.  Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis , 2016, Calcified Tissue International.

[17]  L. Vinay,et al.  Cleavage of Na+ channels by calpain increases persistent Na+ current and promotes spasticity after spinal cord injury , 2016, Nature Medicine.

[18]  H. Sorimachi,et al.  An eccentric calpain, CAPN3/p94/calpain-3. , 2016, Biochimie.

[19]  R. Spanagel,et al.  The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile , 2016, Neuropsychopharmacology.

[20]  P. Hotez,et al.  Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies , 2016, PLoS neglected tropical diseases.

[21]  T. Chiller,et al.  The Global Burden of Fungal Diseases. , 2016, Infectious disease clinics of North America.

[22]  F. Varotti,et al.  Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases. , 2016, Parasitology international.

[23]  Qun Chen,et al.  Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release. , 2016, American journal of physiology. Heart and circulatory physiology.

[24]  V. Jamonneau,et al.  Tolerance to Trypanosomatids: A Threat, or a Key for Disease Elimination? , 2016, Trends in parasitology.

[25]  C. Strang,et al.  Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa , 2016, Cell Death and Disease.

[26]  Hiroshi Mamitsuka,et al.  Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array* , 2016, Molecular & Cellular Proteomics.

[27]  O. Riess,et al.  The calpain-suppressing effects of olesoxime in Huntington's disease , 2016, Rare diseases.

[28]  D. Klatzmann,et al.  Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression , 2016, The Journal of Immunology.

[29]  I. Nelson,et al.  A new titinopathy , 2015, Neurology.

[30]  S. Yamanaka,et al.  From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing. , 2015, Annual review of genetics.

[31]  C. Calaminus,et al.  Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat. , 2015, Brain : a journal of neurology.

[32]  J. Dubois-Randé,et al.  Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation. , 2015, American journal of physiology. Heart and circulatory physiology.

[33]  N. Rawlings.  Bacterial calpains and the evolution of the calpain (C2) family of peptidases , 2015, Biology Direct.

[34]  S. Xiong,et al.  Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy , 2015, Diabetes.

[35]  B. Elliott,et al.  Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion , 2015, Molecular biology of the cell.

[36]  C. M. d'Avila-Levy,et al.  Expression of calpain-like proteins and effects of calpain inhibitors on the growth rate of Angomonas deanei wild type and aposymbiotic strains , 2015, BMC Microbiology.

[37]  Gregory R J Thatcher,et al.  Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors , 2015, Acta pharmaceutica Sinica. B.

[38]  J. Enghild,et al.  Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase* , 2015, The Journal of Biological Chemistry.

[39]  Yunchao Su,et al.  Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis. , 2015, Biochimica et biophysica acta.

[40]  P. Rizkallah,et al.  Conformationally restricted calpain inhibitors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01158b Click here for additional data file. , 2015, Chemical science.

[41]  Katherine J. Wert,et al.  CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model. , 2015, Human molecular genetics.

[42]  C. Angelini,et al.  Protein and genetic diagnosis of limb girdle muscular dystrophy type 2A: The yield and the pitfalls , 2015, Muscle & nerve.

[43]  K. Otsu,et al.  Degradation systems in heart failure. , 2015, Journal of molecular and cellular cardiology.

[44]  April A. Cox,et al.  Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice , 2015, Molecular Neurobiology.

[45]  T. Yamashita,et al.  Delivery of Topically Applied Calpain Inhibitory Peptide to the Posterior Segment of the Rat Eye , 2015, PloS one.

[46]  Chad E. Grueter,et al.  Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes* , 2015, The Journal of Biological Chemistry.

[47]  A. Bassuk,et al.  Structural Modeling of a Novel CAPN5 Mutation that Causes Uveitis and Neovascular Retinal Detachment , 2015, PloS one.

[48]  Teresa R. O’Meara,et al.  The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator , 2015, PLoS genetics.

[49]  Cinzia Signorini,et al.  Calpain-3 Impairs Cell Proliferation and Stimulates Oxidative Stress-Mediated Cell Death in Melanoma Cells , 2015, PloS one.

[50]  A. Mitchell,et al.  Activation and Alliance of Regulatory Pathways in C. albicans during Mammalian Infection , 2015, PLoS biology.

[51]  S. Rowan,et al.  Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract , 2015, Proceedings of the National Academy of Sciences.

[52]  Daniel M. Iascone,et al.  Spinal muscular atrophy: from tissue specificity to therapeutic strategies , 2015, F1000prime reports.

[53]  I. Donkor.  An updated patent review of calpain inhibitors (2012 – 2014) , 2015, Expert opinion on therapeutic patents.

[54]  S. Zhang,et al.  Cardiac Protective Effects of Dexrazoxane on Animal Cardiotoxicity Model Induced by Anthracycline Combined With Trastuzumab Is Associated With Upregulation of Calpain-2 , 2015, Medicine.

[55]  C. Gregorio,et al.  The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation , 2014, Proceedings of the National Academy of Sciences.

[56]  B. del Bello,et al.  Calpains and cancer: friends or enemies? , 2014, Archives of biochemistry and biophysics.

[57]  P. Boya,et al.  Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa , 2014, Cell Death and Differentiation.

[58]  R. Campbell,et al.  Allosteric inhibitors of calpains: Reevaluating inhibition by PD150606 and LSEAL. , 2014, Biochimica et biophysica acta.

[59]  Tetsushi Sakuma,et al.  Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9 , 2014, Stem cell reports.

[60]  F. Urano,et al.  A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome , 2014, Proceedings of the National Academy of Sciences.

[61]  G. Bonanno,et al.  Role of calpain-1 in the early phase of experimental ALS. , 2014, Archives of biochemistry and biophysics.

[62]  A. Bredenoord,et al.  GWAS identifies four novel eosinophilic esophagitis loci , 2014, Nature Communications.

[63]  E. Rugarli,et al.  BID‐dependent release of mitochondrial SMAC dampens XIAP‐mediated immunity against Shigella , 2014, The EMBO journal.

[64]  K. North,et al.  Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair , 2014, Molecular biology of the cell.

[65]  M. Maki,et al.  Involvement of calpain‐7 in epidermal growth factor receptor degradation via the endosomal sorting pathway , 2014, The FEBS journal.

[66]  M. Razzaque,et al.  Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes , 2014, Scientific Reports.

[67]  E. Masliah,et al.  Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. , 2014, Human molecular genetics.

[68]  T. Saido,et al.  New mouse model of Alzheimer's. , 2014, ACS chemical neuroscience.

[69]  Sookyoung Park,et al.  SNJ‐1945, a calpain inhibitor, protects SH‐SY5Y cells against MPP+ and rotenone , 2014, Journal of neurochemistry.

[70]  N. Banik,et al.  Effects of a novel orally administered calpain inhibitor SNJ‐1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis , 2014, Journal of neurochemistry.

[71]  Andrew M. Rupert,et al.  Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease , 2014, Nature Genetics.

[72]  S. Reed,et al.  Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons. , 2014, The Journal of infectious diseases.

[73]  T. Shearer,et al.  Degeneration and dysfunction of retinal neurons in acute ocular hypertensive rats: involvement of calpains. , 2014, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[74]  Ranjana Singh,et al.  Calpain 5 Is Highly Expressed in the Central Nervous System (CNS), Carries Dual Nuclear Localization Signals, and Is Associated with Nuclear Promyelocytic Leukemia Protein Bodies* , 2014, The Journal of Biological Chemistry.

[75]  L. Pereira de Almeida,et al.  Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease. , 2014, Human molecular genetics.

[76]  S. Itohara,et al.  Single App knock-in mouse models of Alzheimer's disease , 2014, Nature Neuroscience.

[77]  S. Reed,et al.  Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon , 2014, Parasitology Research.

[78]  R. Eisenman,et al.  Stress-induced cleavage of Myc promotes cancer cell survival , 2014, Genes & development.

[79]  L. Tsai,et al.  Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment , 2014, Cell.

[80]  C. Murphy,et al.  Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites , 2014, Histochemistry and Cell Biology.

[81]  S. Reed,et al.  Cross-species protection: Schistosoma mansoni Sm-p80 vaccine confers protection against Schistosoma haematobium in hamsters and baboons. , 2014, Vaccine.

[82]  Lei Wan,et al.  Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. , 2014, Toxicology and applied pharmacology.

[83]  P. Greer,et al.  Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model , 2014, European journal of immunology.

[84]  V. Meininger,et al.  A phase II−III trial of olesoxime in subjects with amyotrophic lateral sclerosis , 2014, European journal of neurology.

[85]  Rama Ranganathan,et al.  A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods , 2014, Nature Communications.

[86]  A. M. Salazar,et al.  Role of calpain-10 in the development of diabetes mellitus and its complications. , 2014, Archives of medical research.

[87]  T. Souto-Padrón,et al.  The Calpain Inhibitor MDL28170 Induces the Expression of Apoptotic Markers in Leishmania amazonensis Promastigotes , 2014, PloS one.

[88]  J. Ge,et al.  Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: an in vitro study in H9c2 cells. , 2014, Virus research.

[89]  Jinping Li,et al.  Reduced syncytin-1 expression in choriocarcinoma BeWo cells activates the calpain1–AIF-mediated apoptosis, implication for preeclampsia , 2014, Cellular and Molecular Life Sciences.

[90]  M. Baudry,et al.  A molecular brake controls the magnitude of long-term potentiation , 2014, Nature Communications.

[91]  S. Orkin,et al.  Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. , 2013, Developmental cell.

[92]  B. Dunn,et al.  A Template‐Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV‐1 Protease , 2013, ChemMedChem.

[93]  M. Baudry,et al.  Distinct Roles for μ-Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration , 2013, The Journal of Neuroscience.

[94]  I. Richard,et al.  Restriction of Calpain3 Expression to the Skeletal Muscle Prevents Cardiac Toxicity and Corrects Pathology in a Murine Model of Limb-Girdle Muscular Dystrophy , 2013, Circulation.

[95]  H. Tomita,et al.  Inhibitory Peptide of Mitochondrial μ-Calpain Protects against Photoreceptor Degeneration in Rhodopsin Transgenic S334ter and P23H Rats , 2013, PloS one.

[96]  Yukiko Kurihara,et al.  Calpain-6 Deficiency Promotes Skeletal Muscle Development and Regeneration , 2013, PLoS genetics.

[97]  S. Daiger,et al.  Genes and mutations causing retinitis pigmentosa , 2013, Clinical genetics.

[98]  K. Hollinger,et al.  The physiological response of protease inhibition in dystrophic muscle , 2013, Acta physiologica.

[99]  C. Mellersh,et al.  Missense Mutation in CAPN1 Is Associated with Spinocerebellar Ataxia in the Parson Russell Terrier Dog Breed , 2013, PloS one.

[100]  V. Maltsev,et al.  Calpain Inhibition Reduces Amplitude and Accelerates Decay of the Late Sodium Current in Ventricular Myocytes from Dogs with Chronic Heart Failure , 2013, PloS one.

[101]  E. Letavernier,et al.  The Calpain/Calpastatin System Has Opposing Roles in Growth and Metastatic Dissemination of Melanoma , 2013, PloS one.

[102]  R. Pruss,et al.  Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF , 2013, British journal of pharmacology.

[103]  Hong-Bin Shen,et al.  LabCaS: Labeling calpain substrate cleavage sites from amino acid sequence using conditional random fields , 2013, Proteins.

[104]  E. Hall,et al.  Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ‐1945 in a mouse traumatic brain injury model , 2013, Journal of neurochemistry.

[105]  David S. Park,et al.  Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury , 2013, The Journal of Neuroscience.

[106]  C. Whitchurch,et al.  Calpains, Cleaved Mini-DysferlinC72, and L-Type Channels Underpin Calcium-Dependent Muscle Membrane Repair , 2013, The Journal of Neuroscience.

[107]  K. Obata,et al.  A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts , 2013, The Journal of Physiological Sciences.

[108]  B. del Bello,et al.  Cisplatin-Induced Apoptosis Inhibits Autophagy, Which Acts as a Pro-Survival Mechanism in Human Melanoma Cells , 2013, PloS one.

[109]  Makoto Sato,et al.  Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly , 2013, Scientific Reports.

[110]  Sun Choi,et al.  Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development , 2013, Malaria Journal.

[111]  C. Richter,et al.  Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). , 2013, Human molecular genetics.

[112]  Андреас Клинг,et al.  Carboxamide compounds and their use as calpain inhibitors , 2013 .

[113]  A. Wynshaw-Boris,et al.  ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. , 2013, Journal of neurophysiology.

[114]  N. Banik,et al.  Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats , 2013, Journal of neurochemistry.

[115]  A. Chishti,et al.  Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. , 2012, The Biochemical journal.

[116]  H. Tomita,et al.  Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa. , 2012, Biochimica et biophysica acta.

[117]  R. Campbell,et al.  Structure-function relationships in calpains. , 2012, The Biochemical journal.

[118]  W. Jiao,et al.  New Tripeptide‐Based Macrocyclic Calpain Inhibitors Formed by N‐Alkylation of Histidine , 2012, Chemistry & biodiversity.

[119]  Xiaozhen Hu,et al.  Development of α-helical calpain probes by mimicking a natural protein-protein interaction. , 2012, Journal of the American Chemical Society.

[120]  Beiqing Pan,et al.  The application and biology of immunomodulatory drugs (IMiDs) in cancer. , 2012, Pharmacology & therapeutics.

[121]  V. Sheffield,et al.  Calpain-5 Mutations Cause Autoimmune Uveitis, Retinal Neovascularization, and Photoreceptor Degeneration , 2012, PLoS genetics.

[122]  E. Letavernier,et al.  The role of calpains in myocardial remodelling and heart failure. , 2012, Cardiovascular research.

[123]  K. Shalchian-Tabrizi,et al.  Massive expansion of the calpain gene family in unicellular eukaryotes , 2012, BMC Evolutionary Biology.

[124]  Jill-Desiree Brederson,et al.  The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo , 2012, Neuropharmacology.

[125]  Hiroshi Mamitsuka,et al.  Understanding the substrate specificity of conventional calpains , 2012, Biological chemistry.

[126]  R. Schulz,et al.  Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity. , 2012, Biochemical and biophysical research communications.

[127]  J. King,et al.  Protein misfolding and aggregation in cataract disease and prospects for prevention. , 2012, Trends in molecular medicine.

[128]  H. Sorimachi,et al.  Regulation and physiological roles of the calpain system in muscular disorders , 2012, Cardiovascular research.

[129]  A. Jeromin,et al.  Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases , 2012, Current Translational Geriatrics and Experimental Gerontology Reports.

[130]  Da Yu Li,et al.  Synthesis and evaluation of peptidyl α,β-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors , 2012, Archives of Pharmacal Research.

[131]  T. Maeda.  The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi , 2012, The FEBS journal.

[132]  M. Maki,et al.  Evolutionary and physical linkage between calpains and penta‐EF‐hand Ca2+‐binding proteins , 2012, The FEBS journal.

[133]  J. Tschopp,et al.  Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. , 2012, Immunity.

[134]  Joana M. Xavier,et al.  Distinct Regulatory Functions of Calpain 1 and 2 during Neural Stem Cell Self-Renewal and Differentiation , 2012, PloS one.

[135]  T. Suhara,et al.  Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[136]  S. Sanyal,et al.  Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: exploring NHE-1, intracellular calcium homeostasis and Calpain 9. , 2012, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[137]  P. Kuwabara,et al.  The Atypical Calpains: Evolutionary Analyses and Roles in Caenorhabditis elegans Cellular Degeneration , 2012, PLoS genetics.

[138]  H. Sakurai,et al.  Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation , 2012, Human Cell.

[139]  C. Zimmer,et al.  Olesoxime accelerates myelination and promotes repair in models of demyelination , 2012, Annals of neurology.

[140]  R. Dhir,et al.  Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion , 2012, Molecular Cancer.

[141]  Deborah A. Howatt,et al.  Calpain Inhibition Attenuates Angiotensin II–induced Abdominal Aortic Aneurysms and Atherosclerosis in Low-density Lipoprotein Receptor–deficient Mice , 2012, Journal of cardiovascular pharmacology.

[142]  T. Saido,et al.  A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology , 2012, Nature Communications.

[143]  M. Murakami,et al.  m-Calpain Induction in Vascular Endothelial Cells on Human and Mouse Atheromas and Its Roles in VE-Cadherin Disorganization and Atherosclerosis , 2011 .

[144]  A. Chishti,et al.  Pharmacological inhibition of calpain‐1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[145]  R. Mortara,et al.  The Repetitive Cytoskeletal Protein H49 of Trypanosoma cruzi Is a Calpain-Like Protein Located at the Flagellum Attachment Zone , 2011, PloS one.

[146]  F. Leturcq,et al.  Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations? , 2011, Muscle & nerve.

[147]  Y. Li,et al.  Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes , 2011, Diabetes.

[148]  Joe N. Kornegay,et al.  Chronic Administration of a Leupeptin-Derived Calpain Inhibitor Fails to Ameliorate Severe Muscle Pathology in a Canine Model of Duchenne Muscular Dystrophy , 2011, Front. Pharmacol..

[149]  E. Kudryashova,et al.  Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3. , 2011, Human molecular genetics.

[150]  I. Komuro,et al.  Calpain Protects the Heart from Hemodynamic Stress* , 2011, The Journal of Biological Chemistry.

[151]  A. Chishti,et al.  Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival , 2011, Molecular and Cellular Biology.

[152]  H. Sorimachi,et al.  Impact of genetic insights into calpain biology. , 2011, Journal of biochemistry.

[153]  H. Sorimachi,et al.  Calpain chronicle—an enzyme family under multidisciplinary characterization , 2011, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[154]  Hiroshi Mamitsuka,et al.  Calpain Cleavage Prediction Using Multiple Kernel Learning , 2011, PloS one.

[155]  Neil O. Carragher,et al.  The calpain system and cancer , 2011, Nature Reviews Cancer.

[156]  Zexian Liu,et al.  GPS-CCD: A Novel Computational Program for the Prediction of Calpain Cleavage Sites , 2011, PloS one.

[157]  R. Menna-Barreto,et al.  MDL28170, a Calpain Inhibitor, Affects Trypanosoma cruzi Metacyclogenesis, Ultrastructure and Attachment to Rhodnius prolixus Midgut , 2011, PloS one.

[158]  N. Banik,et al.  Calpeptin attenuated apoptosis and intracellular inflammatory changes in muscle cells , 2011, Journal of neuroscience research.

[159]  C. Ottenheijm,et al.  Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles. , 2011, Journal of molecular biology.

[160]  N. Katunuma.  Structure-based development of specific inhibitors for individual cathepsins and their medical applications , 2011, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[161]  Alan Wells,et al.  Calpains as potential anti-cancer targets , 2011, Expert opinion on therapeutic targets.

[162]  T. Nakano,et al.  The calpain inhibitor calpeptin prevents bleomycin‐induced pulmonary fibrosis in mice , 2010, Clinical and experimental immunology.

[163]  H. Sweeney,et al.  Leupeptin-based inhibitors do not improve the mdx phenotype. , 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

[164]  T. van Veen,et al.  Photoreceptor rescue and toxicity induced by different calpain inhibitors , 2010, Journal of neurochemistry.

[165]  G. Dorn,et al.  Receptor-Independent Cardiac Protein Kinase C&agr; Activation by Calpain-Mediated Truncation of Regulatory Domains , 2010, Circulation research.

[166]  Tomomi Metoki,et al.  Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration. , 2010, Experimental eye research.

[167]  G. Salvesen,et al.  Emerging principles in protease-based drug discovery , 2010, Nature Reviews Drug Discovery.

[168]  N. Banik,et al.  Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis , 2010, Journal of neuroscience research.

[169]  R. Eisenman,et al.  Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation , 2010, Cell.

[170]  C. Ottenheijm,et al.  Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. , 2010, The Journal of clinical investigation.

[171]  K. Sakimura,et al.  Calpain 8/nCL-2 and Calpain 9/nCL-4 Constitute an Active Protease Complex, G-Calpain, Involved in Gastric Mucosal Defense , 2010, PLoS genetics.

[172]  H. Sorimachi,et al.  Skeletal Muscle-specific Calpain Is an Intracellular Na+-dependent Protease* , 2010, The Journal of Biological Chemistry.

[173]  M. Gaspari,et al.  Calpain3 Is Expressed in a Proteolitically Active Form in Papillomavirus-Associated Urothelial Tumors of the Urinary Bladder in Cattle , 2010, PloS one.

[174]  H. Schoemaker,et al.  Inhibition of calpain prevents NMDA‐induced cell death and β‐amyloid‐induced synaptic dysfunction in hippocampal slice cultures , 2010, British journal of pharmacology.

[175]  N. Bourg,et al.  Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases. , 2009, Biochimica et biophysica acta.

[176]  L. Juliano,et al.  Irreversible inhibition of human cathepsins B, L, S and K by hypervalent tellurium compounds , 2009, Biological chemistry.

[177]  Makoto Sato,et al.  Inhibition of calpain increases LIS1(PAFAH1B1) and partially rescues in vivo phenotypes in a mouse model of lissencephaly , 2009, Nature Medicine.

[178]  Kris Gevaert,et al.  SitePredicting the cleavage of proteinase substrates. , 2009, Trends in biochemical sciences.

[179]  D. Roos,et al.  Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells , 2009, Science.

[180]  D. Kuhn,et al.  Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors. , 2009, Blood.

[181]  D. Rosenbaum,et al.  A novel calpain inhibitor for treatment of transient retinal ischemia in the rat , 2009, Neuroreport.

[182]  J. Beckmann,et al.  Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3. , 2009, Biochemistry.

[183]  A. Abell,et al.  Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors. , 2009, Angewandte Chemie.

[184]  D. Goldberg,et al.  A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development , 2009, Proceedings of the National Academy of Sciences.

[185]  F. Esteva,et al.  Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer. , 2009 .

[186]  L. Deshmukh,et al.  NMR structural characterization of the penta‐peptide calpain inhibitor , 2009, FEBS letters.

[187]  Kalle Gehring,et al.  Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains , 2008, Nature.

[188]  R. Campbell,et al.  Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin , 2008, Nature.

[189]  R. Neumar,et al.  Neuroprotection with delayed calpain inhibition after transient forebrain ischemia , 2008, Critical care medicine.

[190]  C. Ottenheijm,et al.  Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. , 2008, Human molecular genetics.

[191]  L. Pellizzoni,et al.  SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. , 2008, Human molecular genetics.

[192]  F. Mokhtarian,et al.  Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis , 2008, Brain Research.

[193]  R. Campbell,et al.  Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions. , 2008, Journal of medicinal chemistry.

[194]  E. Letavernier,et al.  Targeting the Calpain/Calpastatin System as a New Strategy to Prevent Cardiovascular Remodeling in Angiotensin II–Induced Hypertension , 2008, Circulation research.

[195]  C. Tepper,et al.  Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence. , 2007, Cancer research.

[196]  H. Sorimachi,et al.  Stomach-specific Calpain, nCL-2/Calpain 8, Is Active without Calpain Regulatory Subunit and Oligomerizes through C2-like Domains* , 2007, Journal of Biological Chemistry.

[197]  A. Chishti,et al.  BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria. , 2007, Molecular and biochemical parasitology.

[198]  Renu Tuteja,et al.  Malaria − an overview , 2007, The FEBS journal.

[199]  C. Henderson,et al.  Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis , 2007, Journal of Pharmacology and Experimental Therapeutics.

[200]  K. Ersfeld,et al.  The calpains: modular designs and functional diversity , 2007, Genome Biology.

[201]  I. Richard,et al.  AAV-mediated delivery of a mutated myostatin propeptide ameliorates calpain 3 but not α-sarcoglycan deficiency , 2007, Gene Therapy.

[202]  Jing Wang,et al.  A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma , 2007, Neuropharmacology.

[203]  G. Dorn,et al.  Cardiomyocyte Degeneration With Calpain Deficiency Reveals a Critical Role in Protein Homeostasis , 2007, Circulation research.

[204]  M. Bogyo,et al.  Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries* , 2007, Journal of Biological Chemistry.

[205]  F. Mackenzie,et al.  The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. , 2007, Journal of molecular biology.

[206]  H. Miyashita,et al.  Retinal penetration of calpain inhibitors in rats after oral administration. , 2006, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[207]  F. Mokhtarian,et al.  A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis , 2006, Journal of Neuroimmunology.

[208]  Yoshihisa Shirasaki,et al.  Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl alpha-ketoamide derivatives containing pyridine moiety. , 2006, Bioorganic & medicinal chemistry.

[209]  R. Campbell,et al.  Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography. , 2006, Biochemistry.

[210]  N. Hooper,et al.  A broad‐spectrum fluorescence‐based peptide library for the rapid identification of protease substrates , 2006, Proteomics.

[211]  I. Richard,et al.  Safety and efficacy of AAV-mediated calpain 3 gene transfer in a mouse model of limb-girdle muscular dystrophy type 2A. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[212]  J. Arthur,et al.  m-Calpain is required for preimplantation embryonic development in mice , 2006, BMC Developmental Biology.

[213]  M. Siebeck,et al.  Calpain inhibition reduces infarct size and improves global hemodynamics and left ventricular contractility in a porcine myocardial ischemia/reperfusion model. , 2005, European journal of pharmacology.

[214]  P. Davies,et al.  Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions. , 2005, The Journal of biological chemistry.

[215]  K. Gull,et al.  Evolutionary Relationships and Protein Domain Architecture in an Expanded Calpain Superfamily in Kinetoplastid Parasites , 2005, Journal of Molecular Evolution.

[216]  E. Brignole,et al.  Cleavage of Human Cytomegalovirus Protease pUL80a at Internal and Cryptic Sites Is Not Essential but Enhances Infectivity , 2005, Journal of Virology.

[217]  H. Dressman,et al.  Gene Expression Changes and Signaling Events Associated with the Direct Antimelanoma Effect of IFN-γ , 2005 .

[218]  C. Angelini,et al.  Extensive scanning of the calpain-3 gene broadens the spectrum of LGMD2A phenotypes , 2005, Journal of Medical Genetics.

[219]  Masayuki Nakamura,et al.  Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site. , 2005, Bioorganic & medicinal chemistry.

[220]  S. Itohara,et al.  Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains , 2005, Journal of Biological Chemistry.

[221]  Shigeyoshi Itohara,et al.  Distinct Mechanistic Roles of Calpain and Caspase Activation in Neurodegeneration as Revealed in Mice Overexpressing Their Specific Inhibitors* , 2005, Journal of Biological Chemistry.

[222]  R. Kennedy,et al.  Characterization of the immune response to DNA vaccination strategies for schistosomiasis candidate antigen, Sm-p80 in the baboon. , 2005, Vaccine.

[223]  R. Campbell,et al.  Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site. , 2004, Journal of molecular biology.

[224]  P. Chabrier,et al.  Novel dual inhibitors of calpain and lipid peroxidation. , 2004, Bioorganic & medicinal chemistry letters.

[225]  E. Kudryashova,et al.  Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro. , 2004, Human molecular genetics.

[226]  A. Mitchell,et al.  Candida albicans Rim13p, a Protease Required for Rim101p Processing at Acidic and Alkaline pHs , 2004, Eukaryotic Cell.

[227]  Peter Tompa,et al.  On the Sequential Determinants of Calpain Cleavage* , 2004, Journal of Biological Chemistry.

[228]  M. Bittner,et al.  Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome , 2004, Oncogene.

[229]  C. Bories,et al.  Miltefosine Induces Apoptosis-Like Death in Leishmania donovani Promastigotes , 2004, Antimicrobial Agents and Chemotherapy.

[230]  D. Phoenix,et al.  Calpains: targets of cataract prevention? , 2004, Trends in molecular medicine.

[231]  T. Boehm,et al.  Capn5 Is Expressed in a Subset of T Cells and Is Dispensable for Development , 2004, Molecular and Cellular Biology.

[232]  H. Sorimachi,et al.  Possible Regulation of the Conventional Calpain System by Skeletal Muscle-specific Calpain, p94/Calpain 3* , 2004, Journal of Biological Chemistry.

[233]  D. E. Goll,et al.  Interaction of calpastatin with calpain: a review , 2004, Biological chemistry.

[234]  Masayuki Nakamura,et al.  Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors. , 2003, Bioorganic & medicinal chemistry.

[235]  J. Glass,et al.  Calpain inhibition protects against Taxol-induced sensory neuropathy. , 2003, Brain : a journal of neurology.

[236]  D. E. Goll,et al.  The calpain system. , 2003, Physiological reviews.

[237]  Ferdinand Regner,et al.  Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability. , 2003, Journal of medicinal chemistry.

[238]  Z. Jia,et al.  Calpain silencing by a reversible intrinsic mechanism , 2003, Nature Structural Biology.

[239]  Masayuki Nakamura,et al.  Exploration of cornea permeable calpain inhibitors as anticataract agents. , 2003, Bioorganic & medicinal chemistry.

[240]  S. Trumbeckaite,et al.  Calpain inhibitor (BSF 409425) diminishes ischemia/reperfusion-induced damage of rabbit heart mitochondria. , 2003, Biochemical pharmacology.

[241]  R. Mellgren,et al.  Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology. , 2002, Human molecular genetics.

[242]  N. Dohmae,et al.  Klotho Protein Deficiency Leads to Overactivation of μ-Calpain* , 2002, The Journal of Biological Chemistry.

[243]  S. Krajewski,et al.  Calpain and Mitochondria in Ischemia/Reperfusion Injury* , 2002, The Journal of Biological Chemistry.

[244]  Steven S. Oh,et al.  Erythrocyte calpain is dispensable for malaria parasite invasion and growth. , 2002, Molecular and biochemical parasitology.

[245]  R. Schnellmann,et al.  Cytoprotective properties of novel nonpeptide calpain inhibitors in renal cells. , 2002, The Journal of pharmacology and experimental therapeutics.

[246]  T. Shearer,et al.  Characterization and Regulation of Lens-specific Calpain Lp82* , 2002, The Journal of Biological Chemistry.

[247]  S. Sandmann,et al.  Activity profile of calpains I and II in chronically infarcted rat myocardium – influence of the calpain inhibitor CAL 9961 , 2002, British journal of pharmacology.

[248]  Z. Jia,et al.  A Ca2+ Switch Aligns the Active Site of Calpain , 2002, Cell.

[249]  T. Maeda,et al.  Domain II of m‐calpain is a Ca2+‐dependent cysteine protease , 2001, FEBS letters.

[250]  A. Chishti,et al.  Disruption of the Mouse μ-Calpain Gene Reveals an Essential Role in Platelet Function , 2001, Molecular and Cellular Biology.

[251]  A. Kakita,et al.  Calpain‐mediated degradation of p35 to p25 in postmortem human and rat brains , 2001, FEBS letters.

[252]  J. Beckmann,et al.  Loss of Calpain 3 Proteolytic Activity Leads to Muscular Dystrophy and to Apoptosis-Associated Iκbα/Nuclear Factor κb Pathway Perturbation in Mice , 2000, The Journal of cell biology.

[253]  S. Cohen,et al.  Antisense RNA-mediated Deficiency of the Calpain Protease, nCL-4, in NIH3T3 Cells Is Associated with Neoplastic Transformation and Tumorigenesis* , 2000, The Journal of Biological Chemistry.

[254]  Tom H. Lindner,et al.  Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus , 2000, Nature Genetics.

[255]  L. Boring,et al.  The Calpain Small Subunit Gene Is Essential: Its Inactivation Results in Embryonic Lethality , 2000, IUBMB life.

[256]  P. Greer,et al.  Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division , 2000, Molecular and Cellular Biology.

[257]  Y. Yoshikawa,et al.  Isolation of Two Novel Genes, Down‐regulated in Gastric Cancer , 2000, Japanese journal of cancer research : Gann.

[258]  M. Fehlings,et al.  Pretreatment with Calpain Inhibitor CEP‐4143 Inhibits Calpain I Activation and Cytoskeletal Degradation, Improves Neurological Function, and Enhances Axonal Survival After Traumatic Spinal Cord Injury , 2000, Journal of neurochemistry.

[259]  R. Huber,et al.  The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[260]  M. Badalamente,et al.  Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition , 2000, Muscle & nerve.

[261]  Z. Jia,et al.  Crystal structure of calpain reveals the structural basis for Ca2+‐dependent protease activity and a novel mode of enzyme activation , 1999, The EMBO journal.

[262]  T. Saido,et al.  Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage , 1999, Brain Research.

[263]  P. Lipton,et al.  Ischemic cell death in brain neurons. , 1999, Physiological reviews.

[264]  D. Bozyczko‐Coyne,et al.  D-amino acid containing, high-affinity inhibitors of recombinant human calpain I. , 1998, Journal of medicinal chemistry.

[265]  K Suzuki,et al.  Functional Defects of a Muscle-specific Calpain, p94, Caused by Mutations Associated with Limb-Girdle Muscular Dystrophy Type 2A* , 1998, The Journal of Biological Chemistry.

[266]  T. Shearer,et al.  SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses. , 1997, Biochimica et biophysica acta.

[267]  L. DeLucas,et al.  Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding , 1997, Nature Structural Biology.

[268]  Se-Jin Lee,et al.  Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member , 1997, nature.

[269]  J. Powers,et al.  Novel Peptidyl α-Keto Amide Inhibitors of Calpains and Other Cysteine Proteases , 1996 .

[270]  E. Lunney,et al.  An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[271]  B. Winblad,et al.  Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and possible correlation to pathological severity. , 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[272]  ユーアン，ポー−ワイ,et al.  α- substituted hydrazides having calpain inhibitory activity , 1996 .

[273]  H. Arst,et al.  Signaling of Ambient pH in Aspergillus Involves a Cysteine Protease (*) , 1995, The Journal of Biological Chemistry.

[274]  K. Suzuki,et al.  Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease. , 1995, Stroke.

[275]  J. Tidball,et al.  Calpains Are Activated in Necrotic Fibers from mdx Dystrophic Mice (*) , 1995, The Journal of Biological Chemistry.

[276]  Isabelle Richard,et al.  Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A , 1995, Cell.

[277]  R. Bartus,et al.  Calpain Inhibitor AK295 Protects Neurons From Focal Brain Ischemia: Effects of Postocdusion Intra-arterial Administration , 1994, Stroke.

[278]  S. Harbeson,et al.  Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain. , 1994, Journal of medicinal chemistry.

[279]  J. Palmer,et al.  Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis. , 1994, Arthritis and rheumatism.

[280]  K. Suzuki,et al.  Spatial resolution of fodrin proteolysis in postischemic brain. , 1993, The Journal of biological chemistry.

[281]  H. Hori,et al.  Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. , 1993, Journal of medicinal chemistry.

[282]  K. Suzuki,et al.  In situ capture of mu-calpain activation in platelets. , 1993, The Journal of biological chemistry.

[283]  T. Shearer,et al.  Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses. , 1992, Toxicology and applied pharmacology.

[284]  E. Satoyoshi.  Therapeutic trials on progressive muscular dystrophy. , 1992, Internal medicine.

[285]  K. Suzuki,et al.  Transcriptional activation of the gene for the large subunit of human m‐calpain by 12‐o‐tetradecanoyl‐phorbol‐13‐acetate , 1992, FEBS letters.

[286]  J. Anagli,et al.  Inactivation of calpain by peptidyl fluoromethyl ketones. , 1992, Journal of medicinal chemistry.

[287]  Y. Saito,et al.  Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors. , 1991, Biochimica et Biophysica Acta.

[288]  M. Strand,et al.  Characterization of cDNA clones encoding a novel calcium-activated neutral proteinase from Schistosoma mansoni. , 1991, The Journal of biological chemistry.

[289]  M. Wasserman,et al.  Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium falciparum. , 1991, Biochimica et biophysica acta.

[290]  L. David,et al.  Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64. , 1991, Investigative ophthalmology & visual science.

[291]  H. Kawasaki,et al.  Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[292]  H. Kawasaki,et al.  Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle. , 1989, The Journal of biological chemistry.

[293]  T. Murachi.  Intracellular regulatory system involving calpain and calpastatin. , 1989, Biochemistry international.

[294]  J. Wiseman,et al.  Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain. , 1988, Biochemical and biophysical research communications.

[295]  J. Morrow,et al.  The calmodulin-binding site in alpha-fodrin is near the calcium-dependent protease-I cleavage site. , 1988, The Journal of biological chemistry.

[296]  T. Tsujinaka,et al.  Synthesis of a new cell penetrating calpain inhibitor (calpeptin). , 1988, Biochemical and biophysical research communications.

[297]  Takaharu Tanaka,et al.  Purification and structure of novel cysteine proteinase inhibitors staccopins P1 and P2, from Staphylococcus tanabeensis , 1987 .

[298]  T. Shearer,et al.  Purification of calpain II from rat lens and determination of endogenous substrates. , 1986, Experimental eye research.

[299]  H. Kawasaki,et al.  Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein? , 1984, Nature.

[300]  T. Sasaki,et al.  Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. , 1984, The Journal of biological chemistry.

[301]  K. Suzuki.  Reaction of calcium-activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid. , 1983, Journal of biochemistry.

[302]  N. Katunuma,et al.  Inhibitions by E-64 derivatives of rat liver cathepsin B and cathepsin L in vitro and in vivo. , 1980, Journal of biochemistry.

[303]  S. Ishii,et al.  Mechanism of association of a specific aldehyde inhibitor, leupeptin, with bovine trypsin. , 1979, Journal of biochemistry.

[304]  K. Imahori,et al.  Studies of a calcium-activated neutral protease from chicken skeletal muscle. I. Purification and characterization. , 1978, Journal of biochemistry.

[305]  M. Tamai,et al.  Isolation and Characterization of E–64, a New Thiol Protease Inhibitor , 1978 .

[306]  T. Aoyagi,et al.  Leupeptins, new protease inhibitors from Actinomycetes. , 1969, The Journal of antibiotics.

[307]  J. Bonner,et al.  Differentiation , 1968, Nature.

[308]  D. Koshland.  Application of a Theory of Enzyme Specificity to Protein Synthesis. , 1958, Proceedings of the National Academy of Sciences of the United States of America.

[309]  K. Sugitani,et al.  Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice. , 2016, Advances in experimental medicine and biology.

[310]  TakuroMiyazaki,et al.  Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial Cells , 2015 .

[311]  Eric Meadows,et al.  A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[312]  N. Bresolin,et al.  Molecular therapeutic strategies for spinal muscular atrophies: current and future clinical trials. , 2014, Clinical therapeutics.

[313]  K. Gull,et al.  Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology , 2014 .

[314]  A. Muhs,et al.  Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. Update 2014. , 2014, Journal of Alzheimer's disease : JAD.

[315]  A. Muhs,et al.  Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. , 2013, Journal of Alzheimer's disease : JAD.

[316]  A. Abell,et al.  A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model. , 2013, Investigative ophthalmology & visual science.

[317]  C. Patterson,et al.  Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease. , 2013, American journal of translational research.

[318]  P. Rosenthal.  Falcipains and other cysteine proteases of malaria parasites. , 2011, Advances in experimental medicine and biology.

[319]  O. Arancio,et al.  Calpain inhibitors, a treatment for alzheimer’s disease , 2007, Journal of Molecular Neuroscience.

[320]  C. Henderson,et al.  Identification and Characterization of Cholest-4-en-3-one , Oxime ( TRO 19622 ) , a Novel Drug Candidate for Amyotrophic Lateral Sclerosis , 2007 .

[321]  J. Engels.  Focus on birth defects research , 2006 .

[322]  K. Suzuki,et al.  The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation , 1999, Molecular and General Genetics MGG.

[323]  Roy J. Vaz,et al.  Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain. , 1999, Bioorganic & Medicinal Chemistry Letters.

[324]  J. Powers,et al.  Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. , 1996, Journal of Medicinal Chemistry.

[325]  A. Krantz.  Chapter 20. Proteinases in Inflammation , 1993 .

[326]  S. Mehdi,et al.  Cell-penetrating inhibitors of calpain. , 1991, Trends in biochemical sciences.

[327]  G. Guroff,et al.  A NEUTRAL, CALCIUM-ACTIVATED PROTEINASE FROM THE SOLUBLE FRACTION OF RAT BRAIN. , 1964, The Journal of biological chemistry.