Development of HCC in patients receiving adefovir dipivoxil for lamivudine‐resistant hepatitis B virus mutants

Aim:  To identify factors for the development of hepatocellular carcinoma (HCC) in the patients who receive adefovir add‐on lamivudine for treatment of lamivudine‐resistant hepatitis B virus (HBV) mutants.

[1]  P. Marcellin,et al.  Long‐term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen–positive chronic hepatitis B , 2008, Hepatology.

[2]  Yoshiyuki Suzuki,et al.  Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up. , 2008, Journal of hepatology.

[3]  Chien-Jen Chen,et al.  Long-term tracking of hepatitis B viral load and the relationship with risk for hepatocellular carcinoma in men. , 2008, Carcinogenesis.

[4]  B. McMahon,et al.  Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. , 2007, Gastroenterology.

[5]  P. Lampertico,et al.  Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients. , 2007, Gastroenterology.

[6]  Yoshiyuki Suzuki,et al.  Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine , 2007, Journal of Gastroenterology.

[7]  W. Delaney Progress in the treatment of chronic hepatitis B: long-term experience with adefovir dipivoxil. , 2007, The Journal of antimicrobial chemotherapy.

[8]  George Kitis,et al.  Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. , 2006, Gastroenterology.

[9]  Hirotoshi Nakamura,et al.  Changes in viral loads of lamivudine‐resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy , 2006, Journal of medical virology.

[10]  E. Schiff,et al.  A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[11]  Guan-Tarn Huang,et al.  Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. , 2006, JAMA.

[12]  Yoshiyuki Suzuki,et al.  Adefovir Dipivoxil for Treatment of Breakthrough Hepatitis Caused by Lamivudine-Resistant Mutants of Hepatitis B Virus , 2004, Intervirology.

[13]  D. Ganem,et al.  Hepatitis B virus infection--natural history and clinical consequences. , 2004, The New England journal of medicine.

[14]  Yoshiyuki Suzuki,et al.  Virological and biochemical relapse according to YMDD motif mutant type during long‐term lamivudine monotherapy , 2003, Journal of medical virology.

[15]  M. Mizokami,et al.  Classifying Hepatitis B Virus Genotypes , 2003, Intervirology.

[16]  H. Kumada Continued Lamivudine Therapy in Patients with Chronic Hepatitis B , 2003, Intervirology.

[17]  A. Lok,et al.  Hepatitis B virus genotypes in the United States: results of a nationwide study. , 2003, Gastroenterology.

[18]  G. Plosker,et al.  Adefovir dipivoxil: a review of its use in chronic hepatitis B. , 2003, Drugs.

[19]  Yoshiyuki Suzuki,et al.  Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy. , 2002, Journal of hepatology.

[20]  A. Tsubota,et al.  Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw , 2001, Journal of medical virology.

[21]  T Ichida,et al.  Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan , 2001, Hepatology.

[22]  H. Kumada,et al.  [Chronic hepatitis B]. , 2001, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

[23]  P. Holland,et al.  Differentiation of hepatitis B virus genotypes D and E by ELISA using monoclonal antibodies to epitopes on the preS2-region product. , 2000, Journal of virological methods.

[24]  Ding‐Shinn Chen,et al.  Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. , 2000, Gastroenterology.

[25]  D. Faulds,et al.  Lamivudine , 1999, Drugs.

[26]  H. Okamoto,et al.  Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product. , 1999, Journal of virological methods.

[27]  Ding‐Shinn Chen,et al.  Hepatitis B Virus Infection , 2007 .