Predictors of Long‐Term Survival After Liver Transplantation for Metastatic Endocrine Tumors: An 85‐Case French Multicentric Report

Liver transplantation (LTx) for metastatic endocrine tumors (MET) remains controversial due to the lack of clear selection criteria. From 1989 to 2005, 85 patients underwent LTx for MET. The primary tumor was located in the pancreas or duodenum in 40 cases, digestive tract in 26 and bronchial tree in five. In the remaining 14 cases, primary location was undetermined at the time of LTx. Hepatomegaly (explanted liver ≥120% of estimated standard liver volume) was observed in 53 patients (62%). Extrahepatic resection was performed concomitantly with LTx in 34 patients (40%), including upper abdominal exenteration (UAE) in seven.

[1]  J. O'grady Treatment options for other hepatic malignancies , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[2]  O. Nilsson,et al.  Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors , 2007, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[3]  V. Mazzaferro,et al.  Neuroendocrine tumors metastatic to the liver: how to select patients for liver transplantation? , 2007, Journal of hepatology.

[4]  S. Fenwick,et al.  Hepatic Resection and Transplantation for Primary Carcinoid Tumors of the Liver , 2004, Annals of Surgery.

[5]  O. Nilsson,et al.  Comparison of survival between malignant neuroendocrine tumours of midgut and pancreatic origin , 1999, British Journal of Cancer.

[6]  Roland Materne,et al.  Body surface area and body weight predict total liver volume in Western adults , 2002, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[7]  C. Moertel Karnofsky memorial lecture. An odyssey in the land of small tumors. , 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  O. Nilsson,et al.  Indications and Results of Liver Transplantation in Patients with Neuroendocrine Tumors , 2002, World Journal of Surgery.

[9]  T. Lehnert Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients. , 1998, Transplantation.

[10]  V. Mazzaferro,et al.  Resection versus transplantation for liver metastases from neuroendocrine tumors. , 2001, Transplantation proceedings.

[11]  M. Kidd,et al.  An Analysis of Rare Carcinoid Tumors: Clarifying These Clinical Conundrums , 2004, World Journal of Surgery.

[12]  H. Bismuth,et al.  Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report. , 1997, Annals of surgery.

[13]  G. Gores,et al.  Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[14]  G. Davis,et al.  Indications for liver transplantation. , 2008, Gastroenterology.

[15]  T. Starzl,et al.  Abdominal Organ Cluster Transplantation for the Treatment of Upper Abdominal Malignancies , 1989, Annals of surgery.

[16]  G. Gerken,et al.  Liver transplantation for patients with metastatic endocrine tumors: Single‐center experience with 15 patients , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[17]  J. Norton,et al.  Surgery Increases Survival in Patients With Gastrinoma , 2006, Annals of surgery.

[18]  B. Wiedenmann,et al.  Survival and Clinical Outcome of Patients with Neuroendocrine Tumors of the Gastroenteropancreatic Tract in a German Referral Center , 2004, Annals of the New York Academy of Sciences.

[19]  G. Gores,et al.  Liver transplantation for neuroendocrine tumors: Progress and uncertainty , 2004, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[20]  H. Pitt,et al.  Neuroendocrine Hepatic Metastases: Does Aggressive Management Improve Survival? , 2005, Annals of surgery.

[21]  T. Fishbein,et al.  Liver transplantation for neuroendocrine tumors , 2003, Journal of Gastrointestinal Surgery.

[22]  D. Canes,et al.  Hepatic neuroendocrine metastases: does intervention alter outcomes? , 2000, Journal of the American College of Surgeons.

[23]  K Püschel,et al.  Standard liver volume in the Caucasian population. , 1999, Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[24]  M. Manns,et al.  Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors. , 2002, Transplantation.

[25]  G. Klöppel,et al.  The Gastroenteropancreatic Neuroendocrine Cell System and Its Tumors: The WHO Classification , 2004, Annals of the New York Academy of Sciences.

[26]  P. Flemming,et al.  Liver transplantation for metastatic neuroendocrine tumors. , 1997, Annals of surgery.

[27]  D. Metz,et al.  Liver transplantation for metastatic neuroendocrine tumor: a case report and review of the literature. , 2005, World journal of gastroenterology.

[28]  R. Gish,et al.  Model for end‐stage liver disease (MELD) exception for uncommon hepatic tumors , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[29]  J. Belghiti,et al.  Primary endocrine tumours of the liver , 2005, The British journal of surgery.

[30]  Leroy,et al.  Consensus conference: Indications for Liver Transplantation, January 19 and 20, 2005, Lyon‐Palais Des Congrès , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[31]  P. Neuhaus,et al.  Endocrine tumours of the gastrointestinal tract. Transplantation in the management of metastatic endocrine tumours. , 2005, Best practice & research. Clinical gastroenterology.

[32]  M. Rela,et al.  Management of neuroendocrine liver metastases. , 2004, American journal of surgery.