Platelet Sequestration in Man. II. Immunological and

The availability of a method for labeling platelets with Cr5' that allows most of the transfused platelets to remain viable and reduces the initial deposition of nonviable platelets in the liver and spleen (4) permits study of some of these aspects of platelet pathophysiology. We investigated the survival and sites of sequestration of platelets exposed to isoantibodies in vivo. Included in this paper are observations of pyrogenic reactions after immune platelet destruction. Studies in patients with idiopathic thrombocytopenic purpura and other platelet disorders are also described.

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