Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas
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W. Tap | D. Park | T. K. Eisinger-Mathason | M. Simon | S. S. Yoon | C. Hart | M. Simon | H-J Lee | E. Choy | C. Yoon | Y. Lee | Y.J. Lee | H. Lee | Y.-J. Lee | S. Yoon | D. Park | T. S. Eisinger-Mathason
[1] K. Ganjoo,et al. Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] W. Wilson,et al. Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer , 2014, Molecular Cancer Therapeutics.
[3] I. Tannock,et al. Activity of the hypoxia‐activated pro‐drug TH‐302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy , 2014, International journal of cancer.
[4] T. Nielsen,et al. Pazopanib for metastatic soft-tissue sarcoma , 2012, The Lancet.
[5] Tae-Min Kim,et al. Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α , 2012, International journal of cancer.
[6] J. Blay,et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial , 2012, The Lancet.
[7] Damien J. Ferraro,et al. TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules , 2012, Cancer Chemotherapy and Pharmacology.
[8] Damien J. Ferraro,et al. Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer , 2011, Clinical Cancer Research.
[9] P. Glazer,et al. Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302 , 2011, Molecular Cancer Therapeutics.
[10] P. Park,et al. Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. , 2011, International journal of radiation oncology, biology, physics.
[11] J. Bartek,et al. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance , 2011, Nature Cell Biology.
[12] M. Kaag,et al. Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery , 2010, PloS one.
[13] S. Schuetze,et al. Should patients with high-risk soft tissue sarcoma receive adjuvant chemotherapy? , 2009, The oncologist.
[14] H. Taubert,et al. A Three-Gene Signature for Outcome in Soft Tissue Sarcoma , 2009, Clinical Cancer Research.
[15] T. Jacks,et al. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. , 2009, International Journal of Radiation Oncology, Biology, Physics.
[16] John M L Ebos,et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. , 2009, Cancer cell.
[17] Masahiro Inoue,et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009, Cancer cell.
[18] M. Celeste Simon,et al. The impact of O2 availability on human cancer , 2008, Nature Reviews Cancer.
[19] D. Hanahan,et al. Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.
[20] K. Williams,et al. Antiangiogenics and radiotherapy , 2008, The Journal of pharmacy and pharmacology.
[21] A. Lazar,et al. Sarcoma epidemiology and etiology: potential environmental and genetic factors. , 2008, The Surgical clinics of North America.
[22] F. McKeon,et al. Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. , 2008, Cancer cell.
[23] M. Koch,et al. Tumor Escape from Endogenous, Extracellular Matrix–Associated Angiogenesis Inhibitors by Up-Regulation of Multiple Proangiogenic Factors , 2008, Clinical Cancer Research.
[24] R. Hoffman,et al. Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. , 2008, Journal of medicinal chemistry.
[25] Jan Grimm,et al. A spatially and temporally restricted mouse model of soft tissue sarcoma , 2007, Nature Medicine.
[26] Oriol Casanovas,et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. , 2005, Cancer cell.
[27] N. Segal,et al. Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. , 2005, Cancer research.
[28] A. Olshen,et al. Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[29] A. Harris,et al. Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target , 2004, Cell cycle.
[30] A. Dicker,et al. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[31] Zvi Fuks,et al. Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis , 2003, Science.
[32] H. Dvorak. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] Donald W Kufe,et al. Vascular Endothelial Growth Factor Enhances Endothelial Cell Survival and Tumor Radioresistance , 2002, Cancer journal.
[34] Rakesh K. Jain,et al. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy , 2001, Nature Medicine.
[35] Ukcccr. UKCCCR Guidelines for the Use of Cell Lines in Cancer Research , 2000, British Journal of Cancer.
[36] T. Thangarajah,et al. UKCCCR guidelines for the use of cell lines in cancer research , 1999, Cytogenetic and Genome Research.
[37] R. Grimer,et al. Management of Soft Tissue Sarcoma , 1990 .
[38] G. Semenza,et al. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. , 1999, Annual review of cell and developmental biology.