Suppression by HSP 90 inhibitors of BMP ‐ 4 ‐ stimulated osteoprotegerin synthesis in osteoblasts : Attenuation of p 70 S 6 kinase

[1]  O. Kozawa,et al.  (-)-Epigallocatechin gallate but not chlorogenic acid upregulates osteoprotegerin synthesis through regulation of bone morphogenetic protein-4 in osteoblasts. , 2017, Experimental and therapeutic medicine.

[2]  C. Prodromou.  Mechanisms of Hsp 90 regulation , 2017 .

[3]  S. Jamal,et al.  Hsp90: Friends, clients and natural foes. , 2016, Biochimie.

[4]  Osamu Nakamura,et al.  Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells , 2014, International journal of oncology.

[5]  K. Dai,et al.  Osteoblastogenesis regulation signals in bone remodeling , 2012, Osteoporosis International.

[6]  N. Gusev,et al.  Large potentials of small heat shock proteins. , 2011, Physiological reviews.

[7]  Kohei Miyazono,et al.  Bone morphogenetic protein receptors and signal transduction. , 2010, Journal of biochemistry.

[8]  L. Neckers,et al.  Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells , 2007, Clinical Cancer Research.

[9]  G. Chiosis.  Targeting chaperones in transformed systems – a focus on Hsp90 and cancer , 2006, Expert opinion on therapeutic targets.

[10]  R. Stroud,et al.  Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp 90 , 2006 .

[11]  S. Lindquist,et al.  HSP90 and the chaperoning of cancer , 2005, Nature Reviews Cancer.

[12]  M. Waltham,et al.  The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line. , 2005, Cancer research.

[13]  C. Heldin,et al.  Non-Smad TGF-beta signals. , 2005, Journal of cell science.

[14]  S. Kwan Tat,et al.  IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. , 2004, Cytokine & growth factor reviews.

[15]  L. Fritz,et al.  A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors , 2003, Nature.

[16]  E. Wagner,et al.  Reaching a genetic and molecular understanding of skeletal development. , 2002, Developmental cell.

[17]  G. Gademann,et al.  Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones , 2001, Cell stress & chaperones.

[18]  B. Riggs,et al.  Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines. , 1998, Biochemical and biophysical research communications.

[19]  K Yano,et al.  Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. , 1998, Biochemical and biophysical research communications.

[20]  L. Neckers,et al.  The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin , 1998, Cancer Chemotherapy and Pharmacology.

[21]  G Shimamoto,et al.  Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density , 1997, Cell.

[22]  O. Kozawa,et al.  Modulation of the Stress‐Induced Synthesis of hsp27 and αB‐Crystallin by Cyclic AMP in C6 Rat Glioma Cells , 1996, Journal of neurochemistry.

[23]  O. Kozawa,et al.  Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells. , 1992, Experimental cell research.

[24]  Y. Amagai,et al.  In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria , 1983, The Journal of cell biology.

[25]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.