Prognostic value of PRL‐3 overexpression in early stages of colonic cancer

Aims:  High expression of phosphatase of regenerating liver (PRL‐3) has been implicated in cancer invasion and metastasis, indicating a close link between PRL‐3 and cancer development. The aim was to investigate the significance of PRL‐3 expression in the prognosis of colonic cancer.

[1]  F. Zhan,et al.  Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. , 2008, Blood.

[2]  C. Pallen,et al.  PRL-3: A Metastasis-Associated Phosphatase in Search of a Function , 2007, Cells Tissues Organs.

[3]  Q. Zeng,et al.  PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. , 2007, Cancer research.

[4]  Qiang Xu,et al.  PRL-3 siRNA Inhibits the Metastasis of B16-BL6 Mouse Melanoma Cells In Vitro and In Vivo , 2007, Molecular medicine.

[5]  E. Udho,et al.  PRL3 Promotes Cell Invasion and Proliferation by Down-regulation of Csk Leading to Src Activation* , 2007, Journal of Biological Chemistry.

[6]  K. Yanagihara,et al.  High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study , 2007, Virchows Archiv.

[7]  J. Lazo,et al.  PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. , 2007, Cancer research.

[8]  Q. Zeng,et al.  PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. , 2006, Cancer research.

[9]  B. Dong,et al.  Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[10]  L. Kiesel,et al.  Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer , 2006, British Journal of Cancer.

[11]  Xiao-Feng Sun,et al.  Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy. , 2006, International journal of radiation oncology, biology, physics.

[12]  S. Friend,et al.  Cancer Biomarkers—An Invitation to the Table , 2006, Science.

[13]  C. Shou,et al.  Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. , 2006, Biochemical and biophysical research communications.

[14]  A. Cox,et al.  PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. , 2006, Cancer research.

[15]  A. Bardelli,et al.  PRL-3 Phosphatase Is Implicated in Ovarian Cancer Growth , 2005, Clinical Cancer Research.

[16]  A. Fedorov,et al.  Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. , 2005, Biochemistry.

[17]  J. Li,et al.  Catalytic domain of PRL-3 plays an essential role in tumor metastasis: Formation of PRL-3 tumors inside the blood vessels , 2004, Cancer biology & therapy.

[18]  S. Semba,et al.  Expression of PRL-3 Phosphatase in Human Gastric Carcinomas: Close Correlation with Invasion and Metastasis , 2004, Pathobiology.

[19]  C. Shou,et al.  The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer , 2004, Journal of Cancer Research and Clinical Oncology.

[20]  C. Shou,et al.  Preparation and characterization of monoclonal antibody against protein tyrosine phosphatase PRL-3. , 2004, Hybridoma and hybridomics.

[21]  K. Kinzler,et al.  PRL-3 expression in metastatic cancers. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[22]  J. Li,et al.  PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. , 2003, Cancer research.

[23]  New Insights Into Metastasis , 2001, Science.

[24]  Michael A. Choti,et al.  A Phosphatase Associated with Metastasis of Colorectal Cancer , 2001, Science.

[25]  G. Eisen,et al.  Colorectal cancer screening 2000: The role of colonoscopy in average-risk individuals , 2000, Current gastroenterology reports.

[26]  H. Horstmann,et al.  Prenylation-dependent Association of Protein-tyrosine Phosphatases PRL-1, -2, and -3 with the Plasma Membrane and the Early Endosome* , 2000, The Journal of Biological Chemistry.

[27]  P. Traber,et al.  Expression of PRL-1 nuclear PTPase is associated with proliferation in liver but with differentiation in intestine. , 1996, The American journal of physiology.

[28]  R. Taub,et al.  PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth , 1994, Molecular and cellular biology.

[29]  R. Bucala,et al.  Culture and analysis of circulating fibrocytes. , 2007, Methods in molecular medicine.

[30]  加藤 洋隆 High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer : a predictive molecular marker of metachronous liver and lung metastases , 2005 .

[31]  S. Woolf,et al.  AMERICAN GASTROENTEROLOGICAL ASSOCIATION Colorectal Cancer Screening and Surveillance : Clinical Guidelines and Rationale — Update Based on New Evidence , 2003 .