Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.
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Jing Gu | Qidong You | Q. You | J. Gu | Zhihong Li | Zhensheng Jiang | Xiaojin Zhang | Xiaojin Zhang | Yue Wu | Zhihong Li | Yue Wu | Zhensheng Jiang | J. Gu
[1] M. Simon,et al. Hypoxia-inducible factors: central regulators of the tumor phenotype. , 2007, Current opinion in genetics & development.
[2] A. Basheer. Chemical chiral pollution: Impact on the society and science and need of the regulations in the 21st century. , 2018, Chirality.
[3] Morten Meldal,et al. Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. , 2002, The Journal of organic chemistry.
[4] Q. You,et al. Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors. , 2015, ACS medicinal chemistry letters.
[5] I. Ali,et al. Insights into the pharmacology of new heterocycles embedded with oxopyrrolidine rings: DNA binding, molecular docking, and anticancer studies , 2017 .
[6] David S Goodsell,et al. 1,2,3‐Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV‐1 Protease Inhibitors , 2005, Chembiochem : a European journal of chemical biology.
[7] B. B. Mishra,et al. Cu-Catalyzed Click Reaction in Carbohydrate Chemistry. , 2016, Chemical reviews.
[8] D. Wesselinova,et al. Synthesis, DNA binding, hemolytic, and anti-cancer assays of curcumin I-based ligands and their ruthenium(III) complexes , 2013, Medicinal Chemistry Research.
[9] G. Rothenberg,et al. Click Chemistry: Copper Clusters Catalyse the Cycloaddition of Azides with Terminal Alkynes , 2005 .
[10] C. Schofield,et al. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. , 2013, Angewandte Chemie.
[11] C. Schofield,et al. Selective inhibition of factor inhibiting hypoxia-inducible factor. , 2005, Journal of the American Chemical Society.
[12] C. Wykoff,et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.
[13] P. Toselli,et al. Hypoxia-response element (HRE)-directed transcriptional regulation of the rat lysyl oxidase gene in response to cobalt and cadmium. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.
[14] P. Ratcliffe,et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. , 2013, ACS chemical biology.
[15] Dariusz Matosiuk,et al. Click chemistry for drug development and diverse chemical-biology applications. , 2013, Chemical reviews.
[16] M. H. Rabinowitz,et al. Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. , 2013, Journal of medicinal chemistry.
[17] J. Keldenich,et al. Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects , 2014, PloS one.
[18] M. Weiss,et al. Anemia: progress in molecular mechanisms and therapies , 2015, Nature Medicine.
[19] A. Joharapurkar,et al. Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia , 2015, Drug Research.
[20] M. Gassmann,et al. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. , 2013, Blood.
[21] A. Trabocchi,et al. Use of click-chemistry in the development of peptidomimetic enzyme inhibitors. , 2014, Current medicinal chemistry.
[22] Q. You,et al. Application of in-vitro screening methods on hypoxia inducible factor prolyl hydroxylase inhibitors. , 2017, Bioorganic & medicinal chemistry.
[23] S. Zeng,et al. Garcinia xanthones as orally active antitumor agents. , 2013, Journal of medicinal chemistry.
[24] M. Pappalardi,et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia , 2017, The Journal of Pharmacology and Experimental Therapeutics.
[25] Peng Zhan,et al. Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries. , 2016, Drug discovery today.
[26] A. von Kriegsheim,et al. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways , 2016, Cell reports.
[27] J. Zondlo,et al. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). , 2006, Proceedings of the National Academy of Sciences of the United States of America.