Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model.
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T. Matsushita | Y. Tabata | M. Kurosaka | R. Kuroda | Takashi Saito | Tomoyuki Matsumoto | Kanto Nagai | T. Matsuzaki
[1] J. Pelletier,et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis , 2014, Annals of the rheumatic diseases.
[2] Shouan Zhu,et al. The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel. , 2014, Biomaterials.
[3] G. Klintmalm,et al. The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence , 2014, Journal of transplantation.
[4] L. Joosten,et al. Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. , 2012, Endocrinology.
[5] T. Matsushita,et al. Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. , 2012, Arthritis and rheumatism.
[6] D. D’Lima,et al. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. , 2012, Arthritis and rheumatism.
[7] M. Lotz,et al. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis , 2011, Annals of the rheumatic diseases.
[8] Y. Iwamoto,et al. CCAAT/enhancer binding protein β regulates expression of matrix metalloproteinase-3 in arthritis , 2011, Annals of the rheumatic diseases.
[9] Siyoung Yang,et al. Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice. , 2011, Arthritis and rheumatism.
[10] José Becerra,et al. Nanomaterials and hydrogel scaffolds for articular cartilage regeneration. , 2011, Tissue engineering. Part B, Reviews.
[11] M. Lotz,et al. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA , 2011, Nature Reviews Rheumatology.
[12] J. Tschopp,et al. Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation , 2011, The Journal of Biological Chemistry.
[13] Kozo Nakamura,et al. A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo‐controlled trial , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[14] D. Klionsky. The autophagy connection. , 2010, Developmental cell.
[15] Y. Tabata,et al. Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[16] P Tugwell,et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. , 2010, Osteoarthritis and cartilage.
[17] F. Navarro-Garcia,et al. Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model , 2010, Apoptosis.
[18] M-P. Hellio Le Graverand-Gastineau. OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed? , 2009 .
[19] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[20] T. Kubo,et al. Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee. , 2009, Clinical and experimental rheumatology.
[21] C. Sanchez,et al. Bone growth during rapamycin therapy in young rats , 2009, BMC pediatrics.
[22] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[23] Guido Kroemer,et al. Autophagy in the Pathogenesis of Disease , 2008, Cell.
[24] K. Fundel,et al. Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. , 2007, The American journal of pathology.
[25] S. Glasson,et al. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. , 2007, Osteoarthritis and cartilage.
[26] Y. Tabata,et al. A novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study. , 2007, Circulation journal : official journal of the Japanese Circulation Society.
[27] J. Jansen,et al. Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. , 2007, Osteoarthritis and cartilage.
[28] T. Cawston,et al. Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. , 2006, Best practice & research. Clinical rheumatology.
[29] T. Aigner,et al. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. , 2006, Advanced drug delivery reviews.
[30] S. Jimenez,et al. Osteoarthritis cartilage histopathology: grading and staging. , 2006, Osteoarthritis and cartilage.
[31] B. Olsen,et al. Activation of the Discoidin Domain Receptor 2 Induces Expression of Matrix Metalloproteinase 13 Associated with Osteoarthritis in Mice*♦ , 2005, Journal of Biological Chemistry.
[32] Tibor Vellai,et al. Genetics: Influence of TOR kinase on lifespan in C. elegans , 2003, Nature.
[33] M. Sporn,et al. The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes , 2003, Arthritis research & therapy.
[34] T. Aigner,et al. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. , 2002, Arthritis and rheumatism.
[35] M. Goldring,et al. Osteoarthritis and cartilage: The role of cytokines , 2000, Current rheumatology reports.
[36] K. Choe,et al. Apoptotic chondrocyte death in human osteoarthritis. , 2000, The Journal of rheumatology.
[37] F. Blanco,et al. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. , 1998, Arthritis and rheumatism.
[38] J. Reginster,et al. Effects of exogenous IL-1β, TNFα, IL-6, IL-8 and LIF on cytokine production by human articular chondrocytes , 1996 .
[39] Stuart L. Schreiber,et al. A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.
[40] K. Otsu,et al. The role of autophagy in the heart , 2009, Cell Death and Differentiation.
[41] 林田 光正. CCAAT/enhancer-binding protein beta mediates expression of matrix metalloproteinase-13 in human articular chondrocytes in inflammatory arthritis , 2009 .
[42] M. Hellio Le Graverand-Gastineau,et al. OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed? , 2009, Osteoarthritis and cartilage.
[43] T. Aigner,et al. Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. , 2005, Arthritis and rheumatism.