Mouse SmI cortex: qualitative and quantitative classification of golgi-impregnated barrel neurons.

The neurons in layer IV of the mouse somatosensory cortex are arranged in a remarkably consistent pattern of multicellular cytoarchitectonic units called "barrels." Each barrel is known to be related, in a one to one manner, to a contralateral whisker or vibrissa on the animal's face. In this study we have examined Golgi-impregnated neurons that comprise the "barrels." Several criteria, some being quantitative measures of dendritic arbors and somal sizes which were obtained with a computer-microscope system, suggest that all barrel neurons can be placed in two classes, the members of which are present in approximately equal numbers. The cells in the two classes can be further subdivided on the basis of the relationship of their processes to the barrels: 85% of them have processes restricted to a single barrel; 15% of them distribute their processes to two or more barrels. From these observations it is possible to suggest that a majority of neurons comprising the barrels would respond initially to movements of only one whisker while the remainder would respond to movements of two or more whiskers. In addition it has been shown that the quantitation of neuronal structure can provide a numerical basis for the classification of neurons in the central nervous system.

[1]  G. Raisman,et al.  EXTRINSIC AFFERENT COMMISSURAL AND ASSOCIATION FIBRES OF HIPPOCAMPUS , 1965 .

[2]  Woolsey Ta.  Somatosensory, auditory and visual cortical areas of the mouse. , 1967 .

[3]  T A Woolsey,et al.  Somatosensory, auditory and visual cortical areas of the mouse. , 1967, The Johns Hopkins medical journal.

[4]  A. Scheibel,et al.  Pattern and field in cortical structure: The rabbit , 1967, The Journal of comparative neurology.

[5]  Richard O. Duda,et al.  Experiments in the recognition of hand-printed text, part II: context analysis , 1968, AFIPS '68 (Fall, part II).

[6]  G. Bourne.  The structure and function of nervous tissue , 1968 .

[7]  T. Woolsey,et al.  The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units. , 1970, Brain research.

[8]  T. Powell,et al.  The mitral and short axon cells of the olfactory bulb. , 1970, Journal of cell science.

[9]  Michael R. Anderberg,et al.  Cluster Analysis for Applications , 1973 .

[10]  T. Woolsey,et al.  Somatosensory Cortex: Structural Alterations following Early Injury to Sense Organs , 1973, Science.

[11]  J. Lund.  Organization of neurons in the visual cortex, area 17, of the monkey (Macaca mulatta) , 1973, The Journal of comparative neurology.

[12]  W. M. Cowan,et al.  A computer system for the measurement of cell and nuclear sizes* , 1973, Journal of microscopy.

[13]  Peter H. A. Sneath,et al.  Numerical Taxonomy: The Principles and Practice of Numerical Classification , 1973 .

[14]  D F Wann,et al.  An on-line digital-computer system for the semiautomatic analysis of Golgi-impregnated neurons. , 1973, IEEE transactions on bio-medical engineering.

[15]  S. Levay,et al.  Synaptic patterns in the visual cortex of the cat and monkey. Electron microscopy of Golgi Preparations , 1973, The Journal of comparative neurology.

[16]  H. Killackey.  Anatomical evidence for cortical subdivisions based on vertically discrete thalamic projections from the ventral posterior nucleus to cortical barrels in the rat. , 1973, Brain research.

[17]  D. V. van Essen,et al.  Cell structure and function in the visual cortex of the cat , 1974, The Journal of physiology.

[18]  T A Woolsey,et al.  The number, size and spatial distribution of neurons in Lamina IV of the mouse SmI neocortex , 1975, The Journal of comparative neurology.

[19]  E. G. Jones,et al.  Varieties and distribution of non‐pyramidal cells in the somatic sensory cortex of the squirrel monkey , 1975, The Journal of comparative neurology.

[20]  T A Woolsey,et al.  On the “selectivity” of the Golgi‐Cox method , 1975, The Journal of comparative neurology.