Association of Estimated Cardiorespiratory Fitness in Midlife With Cardiometabolic Outcomes and Mortality

Key Points Question Is estimated cardiorespiratory fitness (eCRF) in midlife associated with subclinical atherosclerosis, vascular stiffness, and risk of cardiometabolic disease and mortality? Findings In this cohort study of 2962 Framingham Offspring Study participants, higher midlife eCRF was associated with lower burdens of subclinical atherosclerosis and vascular stiffness, and with a lower risk of hypertension, diabetes, chronic kidney disease, cardiovascular disease, and mortality over a mean follow-up of 15 years. Meaning These findings suggest that prognostic ability of midlife eCRF may extend to a wide range of cardiometabolic diseases.