AUTOMATED PROSTATE VOLUME DETERMINATION WITH ULTRASONOGRAPHIC IMAGING

AbstractA method for automated determination of the prostate volume based on planimetric volumetry was developed to overcome subjectivity in prostate volume measurements using ultrasonography. An edge detection method is applied to locate the prostate boundary in sequential ultrasonographic images. During regular examinations, the volume was assessed automatically in 55 patients. The Pearson correlation coefficient of the automated volume compared to the reference prostate volume was 0.93. The estimated ratio of the automated volume to the reference volume was 0.92. This method overcomes the individual subjectivity when interpreting ultrasonographic images, and provides accurate and objective results for followup of benign prostatic hyperplasia treatments and for comparison of multicenter trials. Also, this method is a useful tool for objective determination of prostate specific antigen in proportion to the volume (prostate specific antigen density).

[1]  M. Benson,et al.  The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen. , 1992, The Journal of urology.

[2]  R. J. Lee,et al.  Ultrasonically determined patterns of enlargement in benign prostatic hyperplasia. , 1993, British journal of urology.

[3]  A. Pantuck,et al.  Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. , 1992, The Journal of urology.

[4]  K. Jensen,et al.  Significance of prostatic weight in prostatism. , 1983, Urologia internationalis.

[5]  T. Stamey,et al.  Correlation between serum prostate specific antigen levels and the volume of the individual glandular zones of the human prostate. , 1995, The Journal of urology.

[6]  T. Hald,et al.  Are doctors able to assess prostatic size? , 1978, Scandinavian journal of urology and nephrology.

[7]  R. Clements,et al.  Volume of normal prostate, of prostate cancer, and of benign prostatic hyperplasia: Are correlations with prostate specific antigen clinically useful? , 1992, The Prostate. Supplement.

[8]  P. Scardino,et al.  Ultrasound Determination of Prostate Volume: Comparison of Transrectal (Ellipsoid v Planimetry) and Suprapubic Methods , 1991 .

[9]  G. K. Bhattacharyya,et al.  Statistical Concepts And Methods , 1978 .

[10]  T. Stamey,et al.  Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. II. Radical prostatectomy treated patients. , 1989, The Journal of urology.

[11]  M. Terris,et al.  Determination of prostate volume by transrectal ultrasound. , 1991, The Journal of urology.

[12]  W. Cooner,et al.  Serum PSA adjusted for volume of transition zone (PSAT) is more accurate than PSA adjusted for total gland volume (PSAD) in detecting adenocarcinoma of the prostate. , 1994, Urology.

[13]  D. R. Jones,et al.  Assessment of volume measurement of the prostate using per-rectal ultrasonography. , 1989, British journal of urology.

[14]  C. Bangma,et al.  Errors in transrectal ultrasonic planimetry of the prostate: computer simulation of volumetric errors applied to a screening population. , 1995, Ultrasound in medicine & biology.

[15]  G N Collins,et al.  Relationship between prostate specific antigen, prostate volume and age in the benign prostate. , 1993, British journal of urology.

[16]  H. Knönagel,et al.  Importance of prostatic sonography in the evaluation of conservative therapy of prostatic hyperplasia. , 1990, Urologia internationalis.

[17]  A. Hendrikx,et al.  Ultrasonic determination of prostatic volume: a cadaver study. , 1989, Urology.

[18]  D. Grobbee,et al.  Volume adjustment for intermediate prostate-specific antigen values in a screening population. , 1995, European journal of cancer.

[19]  D. Neal,et al.  Reproducibility of measurement of prostatic volume by ultrasound. Comparison of transrectal and transabdominal methods. , 1988, European urology.

[20]  R G Aarnink,et al.  A practical clinical method for contour determination in ultrasonographic prostate images. , 1994, Ultrasound in medicine & biology.

[21]  A. Hendrikx,et al.  Audex Medical, a new system for digital processing and analysis of ultrasonographic images of the prostate. , 1991, Scandinavian journal of urology and nephrology. Supplementum.

[22]  James V. Beck,et al.  Parameter Estimation in Engineering and Science , 1977 .

[23]  T. Stamey,et al.  Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. I. Untreated patients. , 1989, The Journal of urology.

[24]  R G Aarnink,et al.  Analysis of ultrasonographic prostate images for the detection of prostatic carcinoma: the automated urologic diagnostic expert system. , 1994, Ultrasound in medicine & biology.

[25]  H. Holm,et al.  Transrectal ultrasonic volume determination of the prostate--a preoperative and postoperative study. , 1982, The Journal of urology.

[26]  Y. Ohashi,et al.  Quantitative analysis of ultrasonogram of the prostate , 1986, Journal of clinical ultrasound : JCU.